Patent US5279565A successfully refreshed from Google Patents.
US5279565A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intravascular treatment apparatus and method
Assignee: LocalMed Inc
•
Filing: 1993-02-03
•
Granted: 1994-01-18
•
Expires: 2013-02-03
Abstract
Abstract An intravascular treatment apparatus provides means for infusing a treatment site with an agent and means for positioning the delivery interface against the treatment site which operate independently of one another. In a preferred embodiment, the apparatus includes a flexible body having a deflectable support frame at its distal end. A plurality of platforms, each comprising a plenum and a delivery interface, is coupled to the support frame. The platforms may be deployed radially from the body by deflecting the support frame using an actuator shaft extending through a passage in the body. The platforms are connected to a supply passage through the body. In this way, the apparatus may be positioned within a body lumen, usually an artery, with the platforms near a treatment site. By actuating the actuator shaft, the platforms are deployed against the treatment site. Independently of the platform deployment, a therapeutic agent may be supplied to the platforms and expelled through the delivery interface and into the treatment site to impregnate the treatment site.
Inventors
- 👤 Enrique J. Klein
- 👤 Aaron V. Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:01
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0067; A61M25/0068; A61M25/007; A61M29/00; A61M29/02; A61B; A61B17/00; A61B17/22; A61B2017/22082; A61B2017/22084; A61M25/0043; A61M2025/0057; A61M25/0082; A61M2025/0096; A61M25/10; A61M2025/1043; A61M2025/1095
Claims Analysis
Total Claims: 79
Claim 1
Independent Claim
128 words
Apparatus for administering a therapeutic agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; and means coupled to the support frame for delivering the agent radially outwardly from the support frame under fluid pressure to the treatment site, the delivery means being in contact with the treatment site in the deployed position.
Claim 2
Dependent Claim
128 words
Apparatus for administering a therapeutic agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; and means coupled to the support frame for delivering the agent radially outwardly from the support frame under fluid pressure to the treatment site, the delivery means being in contact with the treatment site in the deployed position.
Claim 3
Dependent Claim
43 words
The apparatus of claim 1 wherein the support frame comprises at least a first beam having a first end connected to the catheter body and a second end connected to the delivery means, the second end being radially deflectable from the catheter body.
Claim 4
Dependent Claim
75 words
The apparatus of claim 2 wherein the support frame further comprises a second beam having a third end connected to the actuator shaft and a radially-deflectable fourth end connected to the delivery means, the distance between the first and third ends being greater than the distance between the second and fourth ends, wherein the third end may be drawn toward the first end by the actuator shaft to radially deflect the second and fourth ends.
Claim 5
Dependent Claim
37 words
The apparatus of claim 2 further comprising cam means attached to the distal end of the actuator shaft, the cam means movable against the first beam by means of the actuator shaft to deflect the second end.
Claim 6
Dependent Claim
42 words
The apparatus of claim 1 wherein the support frame comprises a first beam having a first end connected to the actuator shaft and a second end connected to the delivery means, wherein the second end is radially deflectable from the catheter body.
Claim 7
Dependent Claim
37 words
The apparatus of claim 5 further comprising cam means fixed to the catheter body near the distal end, the cam means configured to engage the first beam by moving the actuator shaft, thereby deflecting the second end.
Claim 8
Dependent Claim
38 words
The apparatus of claim 1 wherein the means for delivering the agent comprises a platform having a contact surface for contacting the treatment site in the deployed position, and a delivery interface through which the agent is delivered.
Claim 9
Dependent Claim
14 words
The apparatus of claim 7 wherein the delivery interface comprises a rigid porous matrix.
Claim 10
Dependent Claim
12 words
The apparatus of claim 8 wherein the porous matrix is sintered metal.
Claim 11
Dependent Claim
13 words
The apparatus of claim 7 wherein the delivery interface comprises a perforate bladder.
Claim 12
Dependent Claim
15 words
The apparatus of claim 7 wherein the delivery interface comprises a manifold of perforate tubes.
Claim 13
Dependent Claim
27 words
The apparatus of claim 7 wherein the delivery interface comprises an open plenum on the platform, the contact surface being disposed about the periphery of the plenum.
Claim 14
Dependent Claim
18 words
The apparatus of claim 7 wherein the delivery interface comprises a support membrane for applying a cell graft.
Claim 15
Dependent Claim
127 words
Apparatus for administering a therapeutic agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent under fluid pressure to the treatment site.
Claim 16
Dependent Claim
127 words
Apparatus for administering a therapeutic agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent under fluid pressure to the treatment site.
Claim 17
Dependent Claim
42 words
The apparatus of claim 14 wherein the support frame comprises at least a first beam having a first end connected to the catheter body and a second end connected to the platform, the second end being radially deflectable from the catheter body.
Claim 18
Dependent Claim
74 words
The apparatus of claim 15 wherein the support frame further comprises a second beam having a third end connected to the actuator shaft and a radially-deflectable fourth end connected to the platform, the distance between the first and third ends being greater than the distance between the second and fourth ends, wherein the third end may be drawn toward the first end by the actuator shaft to radially deflect the second and fourth ends.
Claim 19
Dependent Claim
37 words
The apparatus of claim 15 further comprising cam means attached to the distal end of the actuator shaft, the cam means movable against the first beam by means of the actuator shaft to deflect the second end.
Claim 20
Dependent Claim
42 words
The apparatus of claim 14 wherein the support frame comprises a first beam having a first end connected to the actuator shaft and a second end connected to the delivery interface, wherein the second end is radially deflectable from the catheter body.
Claim 21
Dependent Claim
37 words
The apparatus of claim 18 further comprising cam means fixed to the catheter body near the distal end, the cam means configured to engage the first beam by moving the actuator shaft, thereby deflecting the second end.
Claim 22
Dependent Claim
14 words
The apparatus of claim 14 wherein the delivery interface comprises a rigid porous matrix.
Claim 23
Dependent Claim
12 words
The apparatus of claim 20 wherein the porous matrix is sintered metal.
Claim 24
Dependent Claim
13 words
The apparatus of claim 14 wherein the delivery interface comprises a perforate bladder.
Claim 25
Dependent Claim
15 words
The apparatus of claim 14 wherein the delivery interface comprises a manifold of perforate tubes.
Claim 26
Dependent Claim
27 words
The apparatus of claim 14 wherein the delivery interface comprises an open plenum on the platform, the contact surface being disposed about the periphery of the plenum.
Claim 27
Dependent Claim
18 words
The apparatus of claim 14 wherein the delivery interface comprises a support membrane for applying a cell graft.
Claim 28
Dependent Claim
17 words
The apparatus of claim 14 further comprising means for communicating the therapeutic agent to the delivery interface.
Claim 29
Dependent Claim
34 words
The apparatus of claim 26 wherein the communicating means comprises a delivery passage through the catheter body, a distal end of the delivery passage being connected to the delivery interface by a feeder tube.
Claim 30
Dependent Claim
38 words
The apparatus of claim 26 wherein the communicating means comprises a collapsible drug-containing capsule disposed in an aperture at the distal end of the catheter body, and a feeder tube for connecting the capsule to the delivery interface.
Claim 31
Dependent Claim
44 words
The apparatus of claim 28 further comprising a drug supply actuator for collapsing the capsule, the drug supply actuator comprising a piston slidably disposed in the aperture and a rod coupled to the piston and extending through an actuator passage in the catheter body.
Claim 32
Dependent Claim
15 words
The apparatus of claim 29 wherein the feeder tube is selectively connectable to the capsule.
Claim 33
Dependent Claim
28 words
The apparatus of claim 30 wherein the capsule is slidably disposed in the aperture so as to be movable into engagement with the feeder tube by the piston.
Claim 34
Dependent Claim
17 words
The apparatus of claim 31 wherein the feeder tube comprises a sharpened tip for piercing the capsule.
Claim 35
Independent Claim
99 words
A method of administering a therapeutic agent to a treatment site in a wall of a vessel, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating the therapeutic agent to the delivery means; and delivering the therapeutic agent under fluid pressure to the treatment site through a delivery interface on the delivery means.
Claim 36
Independent Claim
99 words
A method of administering a therapeutic agent to a treatment site in a wall of a vessel, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating the therapeutic agent to the delivery means; and delivering the therapeutic agent under fluid pressure to the treatment site through a delivery interface on the delivery means.
Claim 37
Dependent Claim
37 words
The method of claim 33 wherein the support frame is deflected by moving an actuator shaft slidably disposed in a passage through the catheter, the actuator shaft being coupled at its distal end to the support frame.
Claim 38
Dependent Claim
41 words
The method of claim 33 wherein the support frame is deflected by moving an actuator shaft slidably disposed in a passage through the catheter, the actuator shaft being coupled at its distal end to cam means for engaging the support frame.
Claim 39
Dependent Claim
47 words
The method of claim 33 further comprising: discontinuing delivery of the agent; retracting the support frame; repositioning the catheter; radially re-extending the support frame such that the delivery means contacts a second treatment site; and delivering an agent through the delivery interface to a second treatment site.
Claim 40
Dependent Claim
25 words
The method of claim 33 wherein the step of radially extending is performed before any of the agent has been communicated to the delivery means.
Claim 41
Dependent Claim
19 words
The method of claim 33 wherein the step of delivering comprises injecting the agent through a rigid porous matrix.
Claim 42
Dependent Claim
23 words
The method of claim 33 wherein the step of delivering comprises injecting the agent through a perforate bladder coupled to the support frame.
Claim 43
Dependent Claim
25 words
The method of claim 33 wherein the step of delivering comprises injecting the agent through a manifold of perforate tubes coupled to the support frame.
Claim 44
Dependent Claim
41 words
The method of claim 33 wherein the delivery means comprises an open plenum for carrying the agent, the step of delivering comprising maintaining an open side of the plenum against the treatment site to bathe the treatment site in the agent.
Claim 45
Dependent Claim
20 words
The method of claim 41 wherein the agent comprises endothelial cells in a culture medium for seeding the treatment site.
Claim 46
Dependent Claim
19 words
The method of claim 33 wherein the step of delivering comprises applying a cell graft to the treatment site.
Claim 47
Dependent Claim
20 words
The method of claim 33 wherein the vessel is an artery and the treatment site is a region of stenosis.
Claim 48
Dependent Claim
32 words
The method of claim 44 wherein the contact surface of the delivery means is maintained against the treatment site while the agent is delivered for a period of at least 10 minutes.
Claim 49
Dependent Claim
40 words
The method of claim 45 wherein the support frame is configured to allow blood to flow past the catheter such that body tissue downstream from the treatment site is perfused while the delivery means is maintained against the treatment site.
Claim 50
Dependent Claim
164 words
Apparatus for administering an agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent to the treatment site, wherein the delivery interface is selected from the group consisting of a rigid porous matrix, a perforate bladder, a manifold of perforate tubes, an open plenum surrounded by a peripheral contact surface, and a support membrane for applying a cell graft.
Claim 51
Dependent Claim
164 words
Apparatus for administering an agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent to the treatment site, wherein the delivery interface is selected from the group consisting of a rigid porous matrix, a perforate bladder, a manifold of perforate tubes, an open plenum surrounded by a peripheral contact surface, and a support membrane for applying a cell graft.
Claim 52
Dependent Claim
42 words
The apparatus of claim 47 wherein the support frame comprises at least a first beam having a first end connected to the catheter body and a second end connected to the platform, the second end being radially deflectable from the catheter body.
Claim 53
Dependent Claim
74 words
The apparatus of claim 48 wherein the support frame further comprises a second beam having a third end connected to the actuator shaft and a radially-deflectable fourth end connected to the platform, the distance between the first and third ends being greater than the distance between the second and fourth ends, wherein the third end may be drawn toward the first end by the actuator shaft to radially deflect the second and fourth ends.
Claim 54
Dependent Claim
37 words
The apparatus of claim 48 further comprising cam means attached to the distal end of the actuator shaft, the cam means movable against the first beam by means of the actuator shaft to deflect the second end.
Claim 55
Dependent Claim
42 words
The apparatus of claim 47 wherein the support frame comprises a first beam having a first end connected to the actuator shaft and a second end connected to the delivery interface, wherein the second end is radially deflectable from the catheter body.
Claim 56
Dependent Claim
37 words
The apparatus of claim 51 further comprising cam means fixed to the catheter body near the distal end, the cam means configured to engage the first beam by moving the actuator shaft, thereby deflecting the second end.
Claim 57
Dependent Claim
12 words
The apparatus of claim 47 wherein the porous matrix is sintered metal.
Claim 58
Dependent Claim
149 words
Apparatus for administering an agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent to the treatment site; and a collapsible drug-containing capsule disposed in the distal end of the catheter body and a feeder tube for connecting the capsule to the delivery interface.
Claim 59
Dependent Claim
149 words
Apparatus for administering an agent to a treatment site in a body lumen, the apparatus comprising: a catheter body having a distal end, a proximal end and a passage therebetween; a support frame coupled to the catheter body, the support frame being movable between a retracted position adjacent the catheter body and a deployed position radially extended from the catheter body; an actuator shaft extending through the passage and having a distal end for engaging the support frame for moving the support frame between the retracted and deployed positions; a platform coupled to the support frame, the platform having a contact surface for contacting the treatment site in the deployed position and a delivery interface for delivering the agent to the treatment site; and a collapsible drug-containing capsule disposed in the distal end of the catheter body and a feeder tube for connecting the capsule to the delivery interface.
Claim 60
Dependent Claim
42 words
The apparatus of claim 54 wherein the support frame comprises at least a first beam having a first end connected to the catheter body and a second end connected to the platform, the second end being radially deflectable from the catheter body.
Claim 61
Dependent Claim
74 words
The apparatus of claim 55 wherein the support frame further comprises a second beam having a third end connected to the actuator shaft and a radially-deflectable fourth end connected to the platform, the distance between the first and third ends being greater than the distance between the second and fourth ends, wherein the third end may be drawn toward the first end by the actuator shaft to radially deflect the second and fourth ends.
Claim 62
Dependent Claim
37 words
The apparatus of claim 55 further comprising cam means attached to the distal end of the actuator shaft, the cam means movable against the first beam by means of the actuator shaft to deflect the second end.
Claim 63
Dependent Claim
42 words
The apparatus of claim 54 wherein the support frame comprises a first beam having a first end connected to the actuator shaft and a second end connected to the delivery interface, wherein the second end is radially deflectable from the catheter body.
Claim 64
Dependent Claim
37 words
The apparatus of claim 58 further comprising cam means fixed to the catheter body near the distal end, the cam means configured to engage the first beam by moving the actuator shaft, thereby deflecting the second end.
Claim 65
Dependent Claim
44 words
The apparatus of claim 54 further comprising a drug supply actuator for collapsing the capsule, the drug supply actuator comprising a piston slidably disposed in the aperture and a rod coupled to the piston and extending through an actuator passage in the catheter body.
Claim 66
Dependent Claim
15 words
The apparatus of claim 60 wherein the feeder tube is selectively connectable to the capsule.
Claim 67
Dependent Claim
28 words
The apparatus of claim 61 wherein the capsule is slidably disposed in the aperture so as to be movable into engagement with the feeder tube by the piston.
Claim 68
Dependent Claim
17 words
The apparatus of claim 62 wherein the feeder tube comprises a sharpened tip for piercing the capsule.
Claim 69
Independent Claim
128 words
A method of administering an agent to a treatment site in a wall of a vessel, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating an agent to the delivery means; and delivering the agent to the treatment site through a delivery interface on the delivery means, wherein the delivery interface is selected from the group consisting of a rigid porous matrix, a perforate bladder, a manifold of perforate tubes, an open plenum, and a support membrane for applying a cell graft.
Claim 70
Independent Claim
128 words
A method of administering an agent to a treatment site in a wall of a vessel, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating an agent to the delivery means; and delivering the agent to the treatment site through a delivery interface on the delivery means, wherein the delivery interface is selected from the group consisting of a rigid porous matrix, a perforate bladder, a manifold of perforate tubes, an open plenum, and a support membrane for applying a cell graft.
Claim 71
Dependent Claim
37 words
The method of claim 64 wherein the support frame is deflected by moving an actuator shaft slidably disposed in a passage through the catheter, the actuator shaft being coupled at its distal end to the support frame.
Claim 72
Dependent Claim
41 words
The method of claim 64 wherein the support frame is deflected by moving an actuator shaft slidably disposed in a passage through the catheter, the actuator shaft being coupled at its distal end to cam means for engaging the support frame.
Claim 73
Dependent Claim
47 words
The method of claim 64 further comprising: discontinuing delivery of the agent; retracting the support frame; repositioning the catheter; radially re-extending the support frame such that the delivery means contacts a second treatment site; and delivering an agent through the delivery interface to a second treatment site.
Claim 74
Dependent Claim
25 words
The method of claim 64 wherein the step of radially extending is performed before any of the agent has been communicated to the delivery means.
Claim 75
Dependent Claim
26 words
The method of claim 64 wherein the agent comprises endothelial cells in a culture medium for seeding the treatment site through an open plenum delivery interface.
Claim 76
Dependent Claim
20 words
The method of claim 64 wherein the vessel is an artery and the treatment site is a region of stenosis.
Claim 77
Independent Claim
120 words
A method of administering an agent to a stenosis site in a wall of an artery, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating an agent to the delivery means; and delivering the agent to the treatment site through a delivery interface on the delivery means, wherein the contact surface of the delivery means is maintained against the treatment site while the agent is delivered for a period of at least 10 minutes.
Claim 78
Independent Claim
120 words
A method of administering an agent to a stenosis site in a wall of an artery, the method comprising the steps of: transluminally positioning a catheter in the vessel with a distal end of the catheter adjacent the treatment site; radially extending a support frame at the distal end of the catheter such that a contact surface of delivery means coupled to the support frame is against the treatment site; communicating an agent to the delivery means; and delivering the agent to the treatment site through a delivery interface on the delivery means, wherein the contact surface of the delivery means is maintained against the treatment site while the agent is delivered for a period of at least 10 minutes.
Claim 79
Dependent Claim
40 words
The method of claim 71 wherein the support frame is configured to allow blood to flow past the catheter such that body tissue downstream from the treatment site is perfused while the delivery means is maintained against the treatment site.
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| 7.5 Years (Year 8) | 2001-01-17 | 2001-07-19 | 2002-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-17 | 2005-07-19 | 2006-01-18 | $7700.00 | Window Closed / Lapsed |