US5276019A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibitors for replication of retroviruses and for the expression of oncogene products
Assignee: United States Department of Health and Human Services
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Filing: 1988-02-22
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Granted: 1994-01-04
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Expires: 2008-02-22
Abstract
Abstract Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
Inventors
- 👤 Jack S. Cohen
- 👤 Len Neckers
- 👤 Cy Stein
- 👤 Shee L. Loke
- 👤 Kazuo Shinozuka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P31/00; A61P31/12; A61P35/00; C; C07; C07H; C07H21/00; C07H21/04; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1131; C12N15/1132; C12N2310/00; C12N2310/30; C12N2310/31; C12N2310/315; C12N2310/33; C12N2310/335; C12N2310/35; C12N2310/352; C12N2310/3521
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
84 words
A compound capable of inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host of the formula: ##STR3## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 2
Dependent Claim
84 words
A compound capable of inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host of the formula: ##STR3## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 3
Dependent Claim
17 words
The compound of claim 1 wherein n is in the range of from 14 to 30, inclusive.
Claim 4
Dependent Claim
13 words
The compound of claim 2 wherein greater than 95% of X are S.
Claim 5
Dependent Claim
9 words
The compound of claim 3 wherein X is S.
Claim 6
Dependent Claim
16 words
The compound of claim 2 wherein two X are S and the remaining X are O.
Claim 7
Dependent Claim
25 words
The compound of claim 5 wherein the two X which are S are at opposite terminal ends of the compound with respect to one another.
Claim 8
Dependent Claim
23 words
The compound of claim 2 wherein the number of X which are S is equal to the number of X which are O.
Claim 9
Dependent Claim
45 words
The compound of claim 2 wherein the X are grouped in alternating units, said alternating units being, respectively, units in which all X are S and units in which all X are O, and further wherein the number of X in each unit is equal.
Claim 10
Dependent Claim
15 words
The compound of claim 8 wherein the number of X in each unit is one.
Claim 11
Dependent Claim
15 words
The compound of claim 1 wherein said foreign nucleic acid is a viral nucleic acid.
Claim 12
Dependent Claim
17 words
The compound of claim 10 wherein n is in the range of from 14 to 30, inclusive.
Claim 13
Dependent Claim
18 words
The compound of claim 11 wherein said viral nucleic acid is a nucleic acid of human immunodeficiency virus.
Claim 14
Dependent Claim
19 words
The compound of claim 12 wherein said nucleic acid of human immunodeficiency virus is a gag gene nucleic acid.
Claim 15
Dependent Claim
19 words
The compound of claim 12 wherein said nucleic acid of human immunodeficiency virus is a tat-III gene nucleic acid.
Claim 16
Dependent Claim
19 words
The compound of claim 12 wherein said nucleic acid of human immunodeficiency virus is an art/trs gene nucleic acid.
Claim 17
Dependent Claim
13 words
The compound of claim 11 wherein greater than 95% of X are S.
Claim 18
Dependent Claim
9 words
The compound of claim 16 wherein X is S.
Claim 19
Dependent Claim
18 words
The compound of claim 16 wherein said viral nucleic acid is a nucleic acid of human immunodeficiency virus.
Claim 20
Dependent Claim
9 words
The compound of claim 18 wherein X is S.
Claim 21
Dependent Claim
19 words
The compound of claim 18 wherein said nucleic acid of human immunodeficiency virus is a gag gene nucleic acid.
Claim 22
Dependent Claim
19 words
The compound of claim 18 wherein said nucleic acid of human immunodeficiency virus is a tat-III gene nucleic acid.
Claim 23
Dependent Claim
19 words
The compound of claim 18 wherein said nucleic acid of human immunodeficiency virus is an art/trs gene nucleic acid.
Claim 24
Dependent Claim
97 words
A composition for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host, said composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula: ##STR4## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 25
Dependent Claim
97 words
A composition for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host, said composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula: ##STR4## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 26
Dependent Claim
17 words
The composition of claim 23 wherein n is in the range of from 14 to 30, inclusive.
Claim 27
Dependent Claim
13 words
The composition of claim 24 wherein greater than 95% of X are S.
Claim 28
Dependent Claim
9 words
The composition of claim 25 wherein X is S.
Claim 29
Dependent Claim
15 words
The composition of claim 23 wherein said foreign nucleic acid is a viral nucleic acid.
Claim 30
Dependent Claim
17 words
The composition of claim 27 wherein n is in the range of from 14 to 30, inclusive.
Claim 31
Dependent Claim
18 words
The composition of claim 28 wherein said viral nucleic acid is a nucleic acid of human immunodeficiency virus.
Claim 32
Dependent Claim
19 words
The composition of claim 29 wherein said nucleic acid of human immunodeficiency virus is a gag gene nucleic acid.
Claim 33
Dependent Claim
19 words
The composition of claim 29 wherein said nucleic acid of human immunodeficiency virus is a tat-III gene nucleic acid.
Claim 34
Dependent Claim
19 words
The composition of claim 24 wherein said nucleic acid of human immunodeficiency virus is an art/trs gene nucleic acid.
Claim 35
Dependent Claim
13 words
The composition of claim 29 wherein greater than 95% of X are S.
Claim 36
Dependent Claim
9 words
The composition of claim 33 wherein X is S.
Claim 37
Independent Claim
97 words
A method for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host comprising the step of administering to the individual an effective amount of a compound of the formula: ##STR5## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 38
Independent Claim
97 words
A method for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host comprising the step of administering to the individual an effective amount of a compound of the formula: ##STR5## wherein: n is in the range of from 2 to 30, inclusive; X is selected from the group consisting of S and O such that at least one X is S; and B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
Claim 39
Dependent Claim
17 words
The method of claim 35 wherein n is in the range of from 14 to 30, inclusive.
Claim 40
Dependent Claim
13 words
The method of claim 36 wherein greater than 95% of X are S.
Claim 41
Dependent Claim
9 words
The method of claim 37 wherein X is S.
Claim 42
Dependent Claim
15 words
The method of claim 35 wherein said foreign nucleic acid is a viral nucleic acid.
Claim 43
Dependent Claim
17 words
The method of claim 39 wherein n is in the range of from 14 to 30, inclusive.
Claim 44
Dependent Claim
18 words
The method of claim 40 wherein said viral nucleic acid is a nucleic acid of human immunodeficiency virus.
Claim 45
Dependent Claim
13 words
The method of claim 41 wherein greater than 95% of X are S.
Claim 46
Dependent Claim
9 words
The method of claim 42 wherein X is S.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-03 | 1997-07-05 | 1998-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-03 | 2001-07-05 | 2002-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-03 | 2005-07-05 | 2006-01-04 | $7700.00 | Window Closed / Lapsed |