US5264570A
Expired / Lapsed
US
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Method for making 2-[18 F]fluoro-2-deoxy-D-glucose
Assignee: General Electric Co
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Filing: 1992-08-05
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Granted: 1993-11-23
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Expires: 2012-08-05
Abstract
Abstract A method is provided for synthesizing 2-fluoro-2-deoxy-D-glucose having an [ 18 F] fluoride ion employing a dibenzo substituted aminopolyether (Kryptofix 222BB) as a phase-transfer reagent.
Inventors
- 👤 Bruce F. Johnson
- 👤 Donald H. Maylotte
- 👤 Cheryl L. Sabourin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:34
CPC Classifications
C; C07; C07H; C07H5/00; C07H5/02; C07B; C07B59/00; C07B59/005
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
87 words
A method for making 2-[ 18 F]fluoro-2-deoxy-D-glucose which comprises, (1) contacting at a temperature of 40° C. to 100° C., 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-2-deoxy-β-D-mannopyranose and [ 18 F]fluoride ion in the presence of an inert organic solvent and the phase-transfer having the formula, ##STR4## (2) effecting the substantial removal of the organic solvent, (3) heating the resulting mixture of (2) in the presence of an aqueous hydrogen halide until deprotection of the resulting acetylated 2-[ 18 F]fluoro-2-deoxy-D-glucose is effected, and (4) recovering 2-[ 18 F]fluoro-2-deoxy-D-glucose from the mixture of (3).
Claim 2
Independent Claim
87 words
A method for making 2-[ 18 F]fluoro-2-deoxy-D-glucose which comprises, (1) contacting at a temperature of 40° C. to 100° C., 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-2-deoxy-β-D-mannopyranose and [ 18 F]fluoride ion in the presence of an inert organic solvent and the phase-transfer having the formula, ##STR4## (2) effecting the substantial removal of the organic solvent, (3) heating the resulting mixture of (2) in the presence of an aqueous hydrogen halide until deprotection of the resulting acetylated 2-[ 18 F]fluoro-2-deoxy-D-glucose is effected, and (4) recovering 2-[ 18 F]fluoro-2-deoxy-D-glucose from the mixture of (3).
Claim 3
Dependent Claim
13 words
A method in accordance with claim 1, where the organic solvent is acetonitrile.
Claim 4
Dependent Claim
31 words
A method in accordance with claim 1, where the 2-[ 18 F]fluoro-2-deoxy-D-glucose is recovered using a derivatized silica gel column followed by a reverse phase column to effect removal of cryptands.
References Cited (Backward Citations)
US4794178A
Cited
US5169942A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-22 | 1997-05-24 | 1997-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-22 | 2001-05-24 | 2001-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-22 | 2005-05-24 | 2005-11-23 | $7700.00 | Window Closed / Lapsed |