US5169942A
Expired / Lapsed
US
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Method for making 2-(18F)fluoro-2-deoxy-D-glucose
Assignee: General Electric Co
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Filing: 1991-11-21
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Granted: 1992-12-08
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Expires: 2011-11-21
Abstract
Abstract A method is provided for making 2-[ 18 F]fluoro-2- deoxy-D-glucose which employs a phase-transfer reagent, consisting of a tetraalkylammonium bicarbonate, a tetraalkylammonium carbonate, or a mixture of a tetraalkylammonium hydroxide and potassium bicarbonate.
Inventors
- 👤 Bruce F. Johnson
- 👤 Donald H. Maylotte
- 👤 Cheryl L. Sabourin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:03
CPC Classifications
C; C07; C07H; C07H5/00; C07H5/02
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
120 words
A method for making [ 18 F]fluoro-2-deoxy-D-glucose which comprises, (1) contacting at a temperature of 40° C. to 100° C., 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-2-deoxy-β-D-mannopyranose and [ 18 F]fluoride ion in the presence of a 60 to 95 volume % organic solvent solution of a phase-transfer reagent selected from the class consisting of a tetraalkylammonium bicarbonate, a tetraalkylammonium carbonate and a mixture of a tetraalkylammonium hydroxide and potassium bicarbonate, and (2) effecting the substantial removal of the organic solvent, and (3) heating the resulting mixture of (2) in the presence of an aqueous hydrogen halide until deprotection of the resulting acetylated 2-[ 18 F]fluoro-2-deoxy-D-glucose is effected, where the organic solvent of (2) is a member selected from the class consisting of acetonitrile and propionitrile.
Claim 2
Independent Claim
120 words
A method for making [ 18 F]fluoro-2-deoxy-D-glucose which comprises, (1) contacting at a temperature of 40° C. to 100° C., 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-2-deoxy-β-D-mannopyranose and [ 18 F]fluoride ion in the presence of a 60 to 95 volume % organic solvent solution of a phase-transfer reagent selected from the class consisting of a tetraalkylammonium bicarbonate, a tetraalkylammonium carbonate and a mixture of a tetraalkylammonium hydroxide and potassium bicarbonate, and (2) effecting the substantial removal of the organic solvent, and (3) heating the resulting mixture of (2) in the presence of an aqueous hydrogen halide until deprotection of the resulting acetylated 2-[ 18 F]fluoro-2-deoxy-D-glucose is effected, where the organic solvent of (2) is a member selected from the class consisting of acetonitrile and propionitrile.
Claim 3
Dependent Claim
14 words
A method in accordance with claim 1, where the phase-transfer reagent is tetraethylammonium bicarbonate.
Claim 4
Dependent Claim
14 words
A method in accordance with claim 1, where the phase-transfer reagent is tetrabutylammonium bicarbonate.
Claim 5
Dependent Claim
14 words
A method in accordance with claim 1, where the phase-transfer reagent is tetrahexylammonium bicarbonate.
Claim 6
Dependent Claim
20 words
A method in accordance with claim 1, where the phase-transfer reagent is a mixture of tetraalkylammonium hydroxide and potassium bicarbonate.
Claim 7
Dependent Claim
13 words
A method in accordance with claim 1, where the organic solvent is acetonitrile.
References Cited (Backward Citations)
No citation records indexed.
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