US5262067A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device and its use for the separation of plasma from whole blood
Assignee: Roche Diagnostics GmbH
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Filing: 1991-05-10
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Granted: 1993-11-16
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Expires: 2011-05-10
Abstract
Abstract The invention concerns a device and its use for separating plasma from whole blood by means of a fibre-containing layer which contains an erythrocyte-aggregating substance and is characterized in that the fibre-containing layer contains glass fibres which are coated with polyvinyl alcohol or with polyvinyl alcohol/polyvinyl acetate. The invention also concerns a test carrier for the determination of a blood component as well as a process for separation from whole blood in which the device according to the present invention is used.
Inventors
- 👤 Hans-Erich Wilk
- 👤 Peter Vogel
- 👤 Rolf Lerch
- 👤 Erich Schneider
- 👤 Andreas Marschall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:21
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B01; B01D; B01D39/00; B01D39/14; B01D39/20; B01D39/2003; B01D39/2017; G01N33/50; G01N33/52; G01N33/525; B01D2239/00; B01D2239/04; B01D2239/0471; B01D2239/0478; B01D2239/0492; B01D2239/12; B01D2239/1233; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
34 words
A non-hemolyzing device useful in separating plasma or serum from whole blood, comprising a layer which contains (i) glass fibers coated with polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate, and (ii) an erythrocyte aggregating substance.
Claim 2
Dependent Claim
34 words
A non-hemolyzing device useful in separating plasma or serum from whole blood, comprising a layer which contains (i) glass fibers coated with polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate, and (ii) an erythrocyte aggregating substance.
Claim 3
Dependent Claim
44 words
Method for separating plasma or serum from whole blood comprising contacting a whole blood sample to the plasma or blood separating layer device of claim 1 wherein erythrocytes are aggregated and retained therein essentially without hemolysis and wherein plasma is allowed to pass therethrough.
Claim 4
Dependent Claim
18 words
Device of claim 1, wherein said erythrocyte aggregating substance comprises a cationic polymer, a lectin, or an antibody.
Claim 5
Dependent Claim
42 words
Method for separating serum or plasma from whole blood comprising contacting a whole blood sample to the plasma or blood separating layer device of claim 2 wherein erythrocytes are aggregated and retained therein without hemolysis and plasma is allowed to pass therethrough.
Claim 6
Dependent Claim
16 words
Device of claim 3, wherein said cationic polymer is a copolymer of N,N,N', N'-tetramethyl-1,6-hexanediamine and 1,3-dibromopropane.
Claim 7
Dependent Claim
19 words
Device of claim 1, wherein said glass fibers have an average diameter of from 0.5 μm to 2.5 μm.
Claim 8
Dependent Claim
19 words
Device of claim 6, wherein said glass fibers have an average diameter of from 0.5 μm to 1.5 μm.
Claim 9
Dependent Claim
21 words
Device of claim 1, wherein said glass fibers have a density of from 0.1 g/cm 3 to 0.5 g/cm 3 .
Claim 10
Dependent Claim
21 words
Device of claim 8, wherein said glass fibers have a density of from 0.2 g/cm 3 to 0.4 g/cm 3 .
Claim 11
Dependent Claim
28 words
Device of claim 1, wherein said polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate is present in an amount ranging from 0.5-20% by weight of said glass fiber containing layer.
Claim 12
Dependent Claim
28 words
Device of claim 10, wherein said polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate is present in an amount ranging from 1.0-10% by weight of said glass fiber containing layer.
Claim 13
Dependent Claim
42 words
Test carrier useful in separating plasma or serum from whole blood comprising a first non-hemolyzing zone containing glass fibers coated with polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate and containing an erythrocyte aggregating substance, and a second, separate zone for reception of plasma.
Claim 14
Dependent Claim
42 words
Test carrier useful in separating plasma or serum from whole blood comprising a first non-hemolyzing zone containing glass fibers coated with polyvinyl alcohol or polyvinyl alcohol/polyvinyl acetate and containing an erythrocyte aggregating substance, and a second, separate zone for reception of plasma.
Claim 15
Dependent Claim
44 words
Method for separating plasma or serum from whole blood comprising contacting a whole blood sample to the first zone of the test carrier of claim 12 wherein erythrocytes are aggregated and retained therein and plasma or serum passes therethrough into said second, separate zone.
Claim 16
Dependent Claim
18 words
Test carrier of claim 12, wherein said erythrocyte aggregating substance comprises a polymer, a lectin, or an antibody.
Claim 17
Dependent Claim
44 words
Method for separating plasma or serum from whole blood comprising contacting a whole blood sample to the first zone of the test carrier of claim 14 wherein erythrocytes are aggregated and retained therein and plasma or serum passes therethrough into said second, separate zone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-15 | 1997-05-17 | 1997-11-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-15 | 2001-05-17 | 2001-11-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-15 | 2005-05-17 | 2005-11-16 | $7700.00 | Window Closed / Lapsed |