Controlled release osmotic infusion system

Claim 2

A portable infusion device assembly comprising: a. a first pouch containing infusate and fitted with a dispensing nozzle; b. a second pouch in pressure-transmitting relationship to the aforesaid first pouch; c. an integral power source comprising: a pressure-generating means for generating pressure in aforesaid second pouch, comprised of an osmagent and a liquid permeant, wherein a driving fluid is produced when permeant contacts osmagent; an activating means for initiating the action of the aforesaid power generating means; a rate-controlling means for regulating the volume change of the aforesaid first pouch, comprising a semipermeable membrane; d. a fluid-transport means in liquid transmitting relationship between the aforesaid power chamber and the aforesaid delivery chamber, and, e. a connecting means for attaching the aforesaid dispensing nozzle to the object of treatment; and, f. a housing containing the aforesaid first and second pouches and in restraining relationship to the aforesaid first and second pouch.

Claim 3

A portable infusion device assembly comprising: a. a first pouch containing infusate and fitted with a dispensing nozzle; b. a second pouch in pressure-transmitting relationship to the aforesaid first pouch; c. an integral power source comprising: a pressure-generating means for generating pressure in aforesaid second pouch, comprised of an osmagent and a liquid permeant, wherein a driving fluid is produced when permeant contacts osmagent; an activating means for initiating the action of the aforesaid power generating means; a rate controlling means for regulating the volume change of the aforesaid first pouch, comprising a semipermeable membrane; d. a fluid-transport means in liquid transmitting relationship between the aforesaid power chamber and the aforesaid delivery chamber, and, e. a connecting means for attaching the aforesaid dispensing nozzle to the object of treatment; and, f. a housing containing the aforesaid first pouch, second pouch, and power source, and in restraining relationship with the aforesaid first and second pouches.

Claim 4

A portable infusion device assembly comprising: a. a first pouch containing infusate and fitted with a dispensing nozzle; b. a second pouch in pressure-transmitting relationship to the aforesaid first pouch; c. an integral power source comprising: a pressure-generating means for generating pressure in aforesaid second pouch, comprised of an osmagent and a liquid permeant, wherein a driving fluid is produced when permeant contacts osmagent; an activating means for initiating the action of the aforesaid power generating means; a rate controlling means for regulating the volume change of the aforesaid first pouch, comprising a semipermeable membrane; d. a fluid-transport means in liquid transmitting relationship between the aforesaid power chamber and the aforesaid delivery chamber, and, e. a connecting means for attaching the aforesaid dispensing nozzle to the object of treatment; and, f. a housing containing the aforesaid first pouch, second pouch, and power source, and in restraining relationship with the aforesaid first and second pouches.

Claim 5

The device according to claim 1 where the inner space of the first infusate pouch is comprised of: a. drug in dry form; b. pharmaceutically acceptable solvent for said drug; and, c. a breakable seal in separating relationship to said drug and solvent.

Claim 6

The device according to claim 2 where the inner space of the first infusate pouch is comprised of: a. drug in dry form; b. pharmaceutically acceptable solvent for said drug; and, c. a breakable seal in separating relationship to said drug and solvent.

Claim 11

The device of claim 1, where said pouch for containment of the infusate is loaded with infusate separately from the rest of the device assembly, and can then be inserted into said assembly.

Claim 12

The device of claim 2, where said pouch for containment of the infusate can be loaded with infusate separately from the rest of the device assembly, and is then be inserted into said assembly.

Claim 13

The device of claim 1, where said activation means is comprised of a means of breaking a barrier separating the permeant from contact with the semipermeable membrane that is the rate-controlling means.

Claim 14

The device of claim 2, where said activation means is comprised of a means of breaking a barrier separating the permeant from contact with the semipermeable membrane that is the rate-controlling means.

Claim 15

The device of claim 9, where: a. said activation means is a plunger or other means of breaking said barrier; and, b. said barrier is a seal separating the permeant from contact with the semipermeable membrane.

Claim 16

The device of claim 10, where: a. said activation means is a plunger or other means of breaking said barrier; and, b. said barrier is a seal separating the permeant from contact with the semipermeable membrane.

Claim 17

The device according to claim 1 where the drug contained in the infusate pouch is heparin.

Claim 18

The device according to claim 1 where the drug contained in the infusate pouch is insulin.

Claim 19

The device according to claim 2 where the drug contained in the infusate pouch is heparin.

Claim 20

The device according to claim 2 where the drug contained in the infusate pouch is insulin.

Claim 21

The device according to claim 1 where the drug contained in the infusate pouch is fluorouracil.

Claim 22

The device according to claim 2 where the drug contained in the infusate pouch is fluorouracil.

Claim 23

The device according to claim 1 where the drug contained in the infusate pouch is cisplatin.

Claim 24

The device according to claim 2 where the drug contained in the infusate pouch is cisplatin.

Claim 25

The device according to claim 1 where the drug contained in the infusate pouch is gancyclovir.

Claim 26

The device according to claim 2 where the drug contained in the infusate pouch is gancyclovir.

Claim 27

The device according to claim 1 where the drug contained in the infusate pouch is adriamycin.

Claim 28

The device according to claim 2 where the drug contained in the infusate pouch is adriamycin.