Patent US5256156A successfully refreshed from Google Patents.
US5256156A
Expired / Lapsed
US
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Physician closed-loop neuromuscular blocking agent system
Assignee: Baxter International Inc
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Filing: 1992-01-13
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Granted: 1993-10-26
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Expires: 2012-01-13
Abstract
Abstract A semi-automatic infusion system for administration of neuromuscular agents and the like includes a microcomputer-controlled infusion pump with a data input pad. A clinician enters the desired paralysis level and performs periodically an electro-stimulation test to determine the actual paralysis level of the patient. This information is also entered in to the system by the physician which then calculates and administers a new dosage.
Inventors
- 👤 Steven E. Kern
- 👤 James G. Skakoon
- 👤 Dwayne R. Westenskow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:05
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; G; G16; G16H; G16H20/00; G16H20/10; G16H20/17; G16H20/30; A61M5/142; A61M2005/14208; A61M5/145; A61M5/1452; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
97 words
An apparatus for administering a neuromuscular blocking agent to a patient to induce paralysis, said apparatus comprising: means for pumping a neuromuscular blocking agent to a patient; means for controlling the operation of said means for pumping, including manual controls for manually setting the preliminary desired operation of said pumping means and further including means for entering the desired results of patient electro-stimulation test; and means for periodically entering the actual results of patient electro-stimulation tests; wherein said means for controlling alters the operation of said pumping means when said actual results differ from said desired results.
Claim 2
Independent Claim
97 words
An apparatus for administering a neuromuscular blocking agent to a patient to induce paralysis, said apparatus comprising: means for pumping a neuromuscular blocking agent to a patient; means for controlling the operation of said means for pumping, including manual controls for manually setting the preliminary desired operation of said pumping means and further including means for entering the desired results of patient electro-stimulation test; and means for periodically entering the actual results of patient electro-stimulation tests; wherein said means for controlling alters the operation of said pumping means when said actual results differ from said desired results.
Claim 3
Dependent Claim
13 words
The apparatus of claim 1 wherein said electro-stimulation test is a train-of-four test.
Claim 4
Dependent Claim
32 words
The apparatus of claim 1 further comprising replaceable memory means, said replaceable memory means being tailored to match a preselected electro-stimulation test, preselected therapeutic agent, preselected therapeutic time course, or combination thereof.
Claim 5
Dependent Claim
14 words
The apparatus of claim 1 wherein said means for pumping comprises an infusion pump.
Claim 6
Independent Claim
111 words
An apparatus for administering a neuromuscular blocking agent into a patient to induce a selectable level of paralysis, said apparatus comprising: infusion pump means for infusing said agent to said patient; microprocessor means coupled to said infusion pump means for controlling the operation thereof; data input means coupled to said microprocessor means for entering a first signal indicative of a desired paralysis level and a second signal indicative of the actual paralysis level of said patient based on a preselected test; and memory means for storing a program for said microprocessor corresponding to said agent and said test, responsive to which program, said microprocessor determines the operation of said infusion pump.
Claim 7
Independent Claim
111 words
An apparatus for administering a neuromuscular blocking agent into a patient to induce a selectable level of paralysis, said apparatus comprising: infusion pump means for infusing said agent to said patient; microprocessor means coupled to said infusion pump means for controlling the operation thereof; data input means coupled to said microprocessor means for entering a first signal indicative of a desired paralysis level and a second signal indicative of the actual paralysis level of said patient based on a preselected test; and memory means for storing a program for said microprocessor corresponding to said agent and said test, responsive to which program, said microprocessor determines the operation of said infusion pump.
Claim 8
Dependent Claim
14 words
The apparatus of claim 5 wherein said infusion pump operates in a continuous mode.
Claim 9
Dependent Claim
16 words
The apparatus of claim 5 wherein said infusion pump delivers said agent in a bolus mode.
Claim 10
Dependent Claim
13 words
The apparatus of claim 5 wherein said memory means comprises a replaceable ROM.
Claim 11
Dependent Claim
17 words
The apparatus of claim 5 wherein said second signal corresponds to the results of a train-of-four test.
Claim 12
Dependent Claim
12 words
The apparatus of claim 5 further comprising display means for displaying instructions.
Claim 13
Independent Claim
104 words
A method of administering a neuromuscular blocking agent for inducing a preselectable level of paralysis on a patient comprising the steps of: providing an infusion pump system for infusing said patient; microprocessor means coupled to said infusion pump system for controlling the operation thereof; data input means coupled to said microprocessor; entering in said data input means a predetermined level of paralysis; monitoring said patient to determine his actual level of paralysis; entering said actual level in said data input means; and adjusting the infusion of said agent to said patient in accordance with the difference between said actual and predetermined level of paralysis.
Claim 14
Independent Claim
104 words
A method of administering a neuromuscular blocking agent for inducing a preselectable level of paralysis on a patient comprising the steps of: providing an infusion pump system for infusing said patient; microprocessor means coupled to said infusion pump system for controlling the operation thereof; data input means coupled to said microprocessor; entering in said data input means a predetermined level of paralysis; monitoring said patient to determine his actual level of paralysis; entering said actual level in said data input means; and adjusting the infusion of said agent to said patient in accordance with the difference between said actual and predetermined level of paralysis.
Claim 15
Dependent Claim
17 words
The method of claim 11 wherein said actual paralysis level is determined by conducting a electro-stimulation test.
Claim 16
Dependent Claim
12 words
The method of claim 12 wherein said test is a train-of-four test.
Claim 17
Dependent Claim
32 words
The method of claim 11 wherein said infusion pump system includes a replaceable memory unit, and further comprising the step of installing a memory unit corresponding to a preselected agent and test.
Claim 18
Dependent Claim
31 words
The method of claim 11 further comprising the step of administering an initial dose of said agent to establish paralysis in said patient by administering a multiple of the ED95 dose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-10-25 | 1997-04-26 | 1997-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-10-25 | 2001-04-26 | 2001-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-10-25 | 2005-04-26 | 2005-10-26 | $7700.00 | Window Closed / Lapsed |