Sulfonyl urea and carbamate ACAT inhibitors

Claim 1

A method for treating atherosclerosis in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula ##STR30## wherein X is --NH--; wherein Ar is (a) phenyl which is unsubstituted or is substituted with from one to three substituents selected from: alkyl having from 1 to 4 carbon atoms and which is straight or branched, alkoxy having from 1 to 3 carbon atoms and which is straight or branched, hydroxy, fluorine, chlorine, bromine, nitro, cyano, trifluoromethyl, --COOH, --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and which is straight or branched, --(CH 2 ) m NR 3 R 4 wherein m is zero or one, and each of R 3 and R 4 is hydrogen or a straight or branched alkyl group having 1 to 4 carbon atoms; (b) 1- or 2-naphthyl which is unsubstituted or substituted with one to three substituents selected from: alkyl having from 1 to 4 carbon atoms and which is straight or branched, alkoxy having from 1 to 3 carbon atoms and which is straight or branched, hydroxy, fluorine, chlorine, bromine, nitro, cyano, trifluoromethyl, --COOH, --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched, --(CH 2 ) m NR 3 R 4 wherein m, R 3 , and R 4 have the meanings defined above; wherein R 1 is hydrogen, lower alkyl having from 1 to 4 carbon atoms or benzyl; wherein R 2 is ##STR31## wherein each of R 5 and R 6 is hydrogen, methyl, ethyl, phenyl, phenyl substituted with straight or branched lower alkyl having from 1 to 4 carbon atoms, straight or branched lower alkoxy having from 1 to 4 carbon atoms, chlorine, fluorine or bromine, or R 5 and R 6 together with the carbon atom to which they are attached form a cyclic group having from 3 to 8 carbon atoms; and R 7 is a straight or branched alkyl group having from 4 to 16 carbon atoms; and pharmaceutically acceptable salts thereof; in combination with a pharmaceutically acceptable carrier.

Claim 2

A method for treating atherosclerosis in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula ##STR30## wherein X is --NH--; wherein Ar is (a) phenyl which is unsubstituted or is substituted with from one to three substituents selected from: alkyl having from 1 to 4 carbon atoms and which is straight or branched, alkoxy having from 1 to 3 carbon atoms and which is straight or branched, hydroxy, fluorine, chlorine, bromine, nitro, cyano, trifluoromethyl, --COOH, --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and which is straight or branched, --(CH 2 ) m NR 3 R 4 wherein m is zero or one, and each of R 3 and R 4 is hydrogen or a straight or branched alkyl group having 1 to 4 carbon atoms; (b) 1- or 2-naphthyl which is unsubstituted or substituted with one to three substituents selected from: alkyl having from 1 to 4 carbon atoms and which is straight or branched, alkoxy having from 1 to 3 carbon atoms and which is straight or branched, hydroxy, fluorine, chlorine, bromine, nitro, cyano, trifluoromethyl, --COOH, --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and is straight or branched, --(CH 2 ) m NR 3 R 4 wherein m, R 3 , and R 4 have the meanings defined above; wherein R 1 is hydrogen, lower alkyl having from 1 to 4 carbon atoms or benzyl; wherein R 2 is ##STR31## wherein each of R 5 and R 6 is hydrogen, methyl, ethyl, phenyl, phenyl substituted with straight or branched lower alkyl having from 1 to 4 carbon atoms, straight or branched lower alkoxy having from 1 to 4 carbon atoms, chlorine, fluorine or bromine, or R 5 and R 6 together with the carbon atom to which they are attached form a cyclic group having from 3 to 8 carbon atoms; and R 7 is a straight or branched alkyl group having from 4 to 16 carbon atoms; and pharmaceutically acceptable salts thereof; in combination with a pharmaceutically acceptable carrier.