Patent US5248942A successfully refreshed from Google Patents.
US5248942A
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Method of exciting a sample for nmr tomography
Assignee: Bruker Biospin MRI GmbH
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Filing: 1991-11-21
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Granted: 1993-09-28
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Expires: 2011-11-21
Abstract
Abstract In particular with 3D tomography, it is necessary to acquire a large number of individual spectra. Therefore it is advisable to reduce the time needed for the acquisition of a single spectrum without loosing too much in signal-to-noise ratio. To a significant extent, this time is determined by the relaxation time of the spins. Prior to each excitation a significant quantity of these spins have to return into their equilibrium (z-direction of the homogeneous magnetic field) in order to create a usable signal with the next excitation. For spins with long relaxation times T 2 this time can be reduced by a -90° pulse 12 that coincides with the center of the last spin echo 9 with appropriate application of the gradient fields. This -90° pulse returns the x-y magnetization that exists in the x-y plane into the z-direction. The diagnostic relevance can be significantly increased by such a procedure.
Inventors
- 👤 Dieter Ratzel
- 👤 Erich Treiber
- 👤 Bernhard Strobel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:21
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/561
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
183 words
Method for the measurement of nuclear magnetic resonance in selected regions of a body for the purpose of creating cross sectional images with which the body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with a sequence of pulses which includes an excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse the beginning of which coincides with the maximum of the spin-echo produced by the last 180° pulse of the sequence, characterized in that at least two 180° pulses leading to spin-echos are irradiated, in that the application time and strength of the gradient fields are adjusted to the pulse sequence in such a manner that, at the time of occurrence of each 180° pulse, the same nuclear phase condition obtains as for the time of occurrence of the preceding 180° pulse, and in that a read gradient is applied at least during the time of occurrence of a spin-echo, whereby at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase.
Claim 2
Dependent Claim
183 words
Method for the measurement of nuclear magnetic resonance in selected regions of a body for the purpose of creating cross sectional images with which the body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with a sequence of pulses which includes an excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse the beginning of which coincides with the maximum of the spin-echo produced by the last 180° pulse of the sequence, characterized in that at least two 180° pulses leading to spin-echos are irradiated, in that the application time and strength of the gradient fields are adjusted to the pulse sequence in such a manner that, at the time of occurrence of each 180° pulse, the same nuclear phase condition obtains as for the time of occurrence of the preceding 180° pulse, and in that a read gradient is applied at least during the time of occurrence of a spin-echo, whereby at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase.
Claim 3
Dependent Claim
31 words
Method according to claim 1, characterized in that at least during the excitation pulse, a slice selection gradient is applied, and in that the excitation pulse is a slice selective pulse.
Claim 4
Dependent Claim
26 words
Method according to claim 1, characterized in that the 180° pulses are slice selective pulses which are irradiated in the presence of a slice selection gradient.
Claim 5
Dependent Claim
15 words
Method according to claim 1, characterized in that the excitation pulse is a 90° pulse.
Claim 6
Dependent Claim
21 words
Method according to claim 1, characterized in that the FB pulse has a phase opposite to that of the excitation pulse.
Claim 7
Dependent Claim
20 words
Method according to claim 1, characterized in that the direction of the read gradient is changed after each 180° pulse.
Claim 8
Dependent Claim
27 words
Method according to claim 1, characterized in that the gradient fields exhibit a phase encoding gradient whose strength and/or time extent is changed after each 180° pulse.
Claim 9
Dependent Claim
39 words
Method according to claim 1, characterized in that the gradient fields exhibit a phase encoding gradient and that a further phase encoding gradient is utilized, whereby the image signal is analyzed by means of a three dimensional Fourier transformation.
Claim 10
Dependent Claim
19 words
Method according to claim 1, characterized in that the excitation pulse is preceded by an additional 180° inversion pulse.
Claim 11
Dependent Claim
33 words
Method according to claim 1, characterized in that the time of irradiation of the FB pulse is so chosen as to optimize the signal to noise ratio for a given total measurement time.
Claim 12
Dependent Claim
251 words
Method for the measurement of nuclear magnetic resonance in selected regions of a body for the purpose of creating cross sectional images with which the body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with a sequence of pulses which includes excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse the beginning of which coincides with the maximum of the spin-echo produced by the last 180° pulse of the sequence, characterized in that at least two 180° pulses leading to spin-echos are irradiated, in that the application time and strength of the gradient fields are adjusted to the pulse sequence in such a manner that, at the time of occurrence of each 180° pulse, the same nuclear phase condition obtains as for the time of occurrence of the preceding 180° pulse, in that a read gradient is applied at least during the time of occurrence of a spin-echo, whereby at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase, in that at least during the excitation pulse, a slice selection gradient is applied, and in that the excitation pulse is a slice selective pulse, in that the 180° pulses are slice selective pulses which are irradiated in the presence of a slice selection gradient, in that the excitation pulse is a 90° pulse, and in that the FB pulse has a phase opposite to that of the excitation pulse.
Claim 13
Dependent Claim
251 words
Method for the measurement of nuclear magnetic resonance in selected regions of a body for the purpose of creating cross sectional images with which the body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with a sequence of pulses which includes excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse the beginning of which coincides with the maximum of the spin-echo produced by the last 180° pulse of the sequence, characterized in that at least two 180° pulses leading to spin-echos are irradiated, in that the application time and strength of the gradient fields are adjusted to the pulse sequence in such a manner that, at the time of occurrence of each 180° pulse, the same nuclear phase condition obtains as for the time of occurrence of the preceding 180° pulse, in that a read gradient is applied at least during the time of occurrence of a spin-echo, whereby at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase, in that at least during the excitation pulse, a slice selection gradient is applied, and in that the excitation pulse is a slice selective pulse, in that the 180° pulses are slice selective pulses which are irradiated in the presence of a slice selection gradient, in that the excitation pulse is a 90° pulse, and in that the FB pulse has a phase opposite to that of the excitation pulse.
Claim 14
Dependent Claim
20 words
Method according to claim 11, characterized in that the direction of the read gradient is changed after each 180° pulse.
Claim 15
Dependent Claim
27 words
Method according to claim 11, characterized in that the gradient fields exhibit a phase encoding gradient whose strength and/or time extent is changed after each 180° pulse.
Claim 16
Dependent Claim
39 words
Method according to claim 11, characterized in that the gradient fields exhibit a phase encoding gradient and that a further phase encoding gradient is utilized, whereby the image signal is analyzed by means of a three dimensional Fourier transformation.
Claim 17
Dependent Claim
19 words
Method according to claim 11, characterized in that the excitation pulse is preceded by an additional 180° inversion pulse.
Claim 18
Dependent Claim
33 words
Method according to claim 11, characterized in that the time of irradiation of the FB pulse is so chosen as to optimize the signal to noise ratio for a given total measurement time.
Claim 19
Dependent Claim
84 words
Method for the measurement of nuclear magnetic resonance to create cross sectional images with which a body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with an excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse characterized in that at least two 180° pulses leading to spin-echos are irradiated and in that, at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase.
Claim 20
Dependent Claim
84 words
Method for the measurement of nuclear magnetic resonance to create cross sectional images with which a body is subjected to a homogeneous magnetic field and to gradient fields and is irradiated with an excitation pulse and a 180° pulse, whereby the sequence is ended with a FB pulse characterized in that at least two 180° pulses leading to spin-echos are irradiated and in that, at the time at which the FB pulse is irradiated, the spin momenta generating the spin-echo are all in phase.
Claim 21
Dependent Claim
27 words
Method according to claim 17, characterized in that the gradient fields exhibit a phase encoding gradient whose strength and/or time extent is changed after each 180° pulse.
Claim 22
Dependent Claim
39 words
Method according to claim 17, characterized in that the gradient fields exhibit a phase encoding gradient and that a further phase encoding gradient is utilized, whereby the image signal is analyzed by means of a three dimensional Fourier transformation.
Claim 23
Dependent Claim
19 words
Method according to claim 17, characterized in that the excitation pulse is preceded by an additional 180° inversion pulse.
References Cited (Backward Citations)
US4595899A
Cited
US4692704A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-09-27 | 1997-03-29 | 1997-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-27 | 2001-03-29 | 2001-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-27 | 2005-03-29 | 2005-09-28 | $7700.00 | Window Closed / Lapsed |