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Derivatives of long chain fatty alcohols, their uses, particularly as cytotrophic and cytoprotective molecules, and pharmaceutical compositions containing them

Assignee: Medafor
•
Filing: 1990-10-15
•
Granted: 1993-09-07
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Expires: 2010-10-15
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Abstract

Abstract PCT No. PCT/FR90/00742 Sec. 371 Date Jul. 11, 1991 Sec. 102(e) Date Jul. 11, 1991 PCT Filed Oct. 15, 1990 PCT Pub. No. WO91/05754 PCT Pub. Date May 2, 1991.Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.

Inventors

  • 👤 Jacques Borg

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 14:50
CPC Classifications
C; C07; C07C; C07C403/00; C07C403/06; C07C403/12; A; A61; A61P; A61P1/00; A61P1/04; A61P1/16; A61P11/00; A61P13/00; A61P13/02; A61P15/00; A61P17/00; A61P25/00; A61P25/28; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P37/00; A61P37/08; A61P43/00; A61P7/00; A61P7/02; A61P9/00; A61P9/10; C07C255/00; C07C255/01; C07C255/31; C07C33/00; C07C33/02; C07C33/025; C07C33/035; C07C33/05; C07C33/14; C07C403/08; C07C403/20; C07C403/24; C07C45/00; C07C45/27; C07C45/30; C07C45/305; C07C47/00; C07C47/20; C07C47/225; C07C49/00; C07C49/385; C07C49/487; C07C49/507; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6564; C07F9/6571; C07F9/6574; C07F9/65744; C07J; C07J9/00; C07C2601/00; C07C2601/12; C07C2601/14; C07C2601/16

Claims Analysis

Total Claims: 18
Claim 1
Independent Claim 213 words
Derivatives of fatty alcohols, characterized by the following general formula: R.sub.1 --/A--(X).sub.y --B/.sub.p --R.sub.2 in which p is equal to 1 or 2, y=0 or 1, A-(X) y --B is a hydrocarbon chain of 11 to 50 carbon atoms, wherein said hydrocarbon chain is unsubstituted or substituted by one or more alkyl groups of 1 to 3 carbon atoms, or by one or more OR a groups, R a representing H or an alkyl group of 1 to 3 carbon atoms, in which: A and B, identical or different, are saturated or unsaturated aliphatic chain; X is a saturated or unsaturated hydrocarbon chain R 1 and R 2 , identical or different, represent: a group of formula (A): ##STR58## containing a single or a double bond and being unsubstituted or substituted by one or more --CH 3 and/or --OH and/or --OR groups, R being defined below, and/or an oxy (=0) group, a --OR group, in which R represents a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or a ##STR59## group, in which R' represents a hydrogen atom or an alkyl group of 1 to 5 carbon atoms, provided that at least one of the pair of R 1 and R 2 represent a group of the formula (A).
Claim 2
Dependent Claim 213 words
Derivatives of fatty alcohols, characterized by the following general formula: R.sub.1 --/A--(X).sub.y --B/.sub.p --R.sub.2 in which p is equal to 1 or 2, y=0 or 1, A-(X) y --B is a hydrocarbon chain of 11 to 50 carbon atoms, wherein said hydrocarbon chain is unsubstituted or substituted by one or more alkyl groups of 1 to 3 carbon atoms, or by one or more OR a groups, R a representing H or an alkyl group of 1 to 3 carbon atoms, in which: A and B, identical or different, are saturated or unsaturated aliphatic chain; X is a saturated or unsaturated hydrocarbon chain R 1 and R 2 , identical or different, represent: a group of formula (A): ##STR58## containing a single or a double bond and being unsubstituted or substituted by one or more --CH 3 and/or --OH and/or --OR groups, R being defined below, and/or an oxy (=0) group, a --OR group, in which R represents a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or a ##STR59## group, in which R' represents a hydrogen atom or an alkyl group of 1 to 5 carbon atoms, provided that at least one of the pair of R 1 and R 2 represent a group of the formula (A).
Claim 3
Dependent Claim 9 words
Derivatives according to claim 1, characterized in that p=1.
Claim 4
Dependent Claim 42 words
Derivatives according to claim 1 characterized by the following formula: ##STR60## containing 0 to 10 double bonds and in which R 2 represents OR, R having the meaning indicated in claim 1 and n is an integer varying from 2 to 10.
Claim 5
Dependent Claim 18 words
Pharmaceutical composition containing at least one derivative according to claim 1 in combination with a physiological acceptable vehicle.
Claim 6
Dependent Claim 15 words
Composition according to claim 4, containing between 0.5 mg and 500 mg of the derivative.
Claim 7
Dependent Claim 7 words
A derivative characterized by the formula: ##STR61##
Claim 8
Dependent Claim 7 words
A derivative characterized by the formula: ##STR61##
Claim 9
Dependent Claim 7 words
A derivative characterized by the formula: ##STR62##
Claim 10
Dependent Claim 7 words
A derivative characterized by the formula: ##STR62##
Claim 11
Dependent Claim 7 words
A derivative characterized by the formula: ##STR63##
Claim 12
Dependent Claim 7 words
A derivative characterized by the formula: ##STR63##
Claim 13
Dependent Claim 7 words
A derivative having the following formula: ##STR64##
Claim 14
Dependent Claim 7 words
A derivative having the following formula: ##STR64##
Claim 15
Dependent Claim 7 words
A derivative having the following formula: ##STR65##
Claim 16
Dependent Claim 7 words
A derivative having the following formula: ##STR65##
Claim 17
Dependent Claim 7 words
A derivative having the following forumla: ##STR66##
Claim 18
Dependent Claim 7 words
A derivative having the following forumla: ##STR66##

References Cited (Backward Citations)

US3689667A Cited
DE2459985A1 Cited
US4092366A Cited
DE2551914A1 Cited
WO1984001899A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1996-09-06 1997-03-08 1997-09-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2000-09-06 2001-03-08 2001-09-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2004-09-06 2005-03-08 2005-09-07 $7700.00 Window Closed / Lapsed

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