Methods of using lysophosphatidic acids for regulating skin wrinkles

Claim 3

The method of claim 1 wherein --R is unsubstituted or substituted with hydroxy or halogen.

Claim 4

The method of claim 2 wherein --X-- --O--.

Claim 5

The method of claim 3 wherein the compound has the structure. ##STR10##

Claim 6

The method of claim 4 wherein --Y-- is --O--.

Claim 7

The method of claim 5 wherein --R is unsubstituted.

Claim 8

The method of claim 6 wherein --R is straight-chain and is saturated or unsaturated with one double bond.

Claim 9

The method of claim 7 wherein --R has from bout 13 to 17 carbon atoms.

Claim 10

The method of claim 8 wherein RC(O)O-- is selected from the group consisting of oleyl, palmityl and myristyl.

Claim 11

The method of claim 9 wherein RC(O)O-- is myristyl.

Claim 12

The method of claim 1 wherein the amount of the lysophosphatidic acid compound applied to the skin is from about 0.01 mg to about 1 mg per cm 2 skin.

Claim 13

The method of claim 6 wherein the amount of the lysophosphatidic acid compound applied to the skin is from about 0.01 mg to about 1 mg per cm 2 skin.

Claim 14

The method of claim 8 wherein the amount of the lysophosphatidic acid compound applied to the skin is from about 0.01 mg to about 1 mg per cm 2 skin.

Claim 15

The method of claim 9 wherein the amount of the lysophosphatidic acid compound applied to the skin is from about 0.01 mg to about 1 mg per cm 2 skin.

Claim 16

A composition for topical application for preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising: (a) a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR11## or a cyclic derivative thereof having the structure: ##STR12## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH 2 --. (b) a safe and effective amount of a chelating agent capable of forming a complex with a metal ion so that the ion cannot participate in or catalyze chemical reactions; and (c) a safe and effective amount of a topical carrier.

Claim 17

A composition for topical application for preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising: (a) a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR11## or a cyclic derivative thereof having the structure: ##STR12## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH 2 --. (b) a safe and effective amount of a chelating agent capable of forming a complex with a metal ion so that the ion cannot participate in or catalyze chemical reactions; and (c) a safe and effective amount of a topical carrier.

Claim 18

The composition of claim 15 wherein the compound has the structure: ##STR13## wherein --R has from 13 to 17 carbon atoms, is straight-chain, is unsubstituted, and is saturated or has one double bond.