US5238853A
Expired / Lapsed
US
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Process and apparatus for the electrochemical determination of oxygen in a blood gas analyzer
Assignee: Instrumentation Laboratory SpA
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Filing: 1991-09-11
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Granted: 1993-08-24
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Expires: 2011-09-11
Abstract
Abstract In a blood gas analyzer, a substantially oxygen-free measurement solution is fed through a measuring cell as far as a diffusion cell in which the measurement solution is brought into contact with a blood sample to be tested. The gases dissolved in the blood sample diffuse through a membrane in the diffusion cell into the solution. The measurement solution is then propelled in the reverse direction to feed into the measuring cell. In the measuring cell, the measurement solution is electrochemically measured to determine a value which is related to the partial pressure of oxygen (pO 2 ) in the sample.
Inventors
- 👤 Claudio Calzi
- 👤 Gabrio Tancredi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 12:49
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4925; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/117497
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
140 words
A process for determining pO 2 in a blood sample, comprising a. propelling a measurement solution with substantially zero pO 2 along a fluid circuit wherein said solution passes in succession through a measuring cell to a diffusing cell; b. in the diffusion ell, halting the movement of said measurement solution and contacting the measurement solution with the blood sample to be tested via a permeation membrane which is permeable to gases but not to ions for a time sufficient to allow gases dissolved in the blood sample to diffuse through the membrane and into the solution; c. propelling the measurement solution in the reverse direction through the circuit to the measuring cell; and d. in the measuring cell, determining the value of an electrical quantity of the solution which is related to the pO 2 in the blood sample.
Claim 2
Dependent Claim
140 words
A process for determining pO 2 in a blood sample, comprising a. propelling a measurement solution with substantially zero pO 2 along a fluid circuit wherein said solution passes in succession through a measuring cell to a diffusing cell; b. in the diffusion ell, halting the movement of said measurement solution and contacting the measurement solution with the blood sample to be tested via a permeation membrane which is permeable to gases but not to ions for a time sufficient to allow gases dissolved in the blood sample to diffuse through the membrane and into the solution; c. propelling the measurement solution in the reverse direction through the circuit to the measuring cell; and d. in the measuring cell, determining the value of an electrical quantity of the solution which is related to the pO 2 in the blood sample.
Claim 3
Dependent Claim
34 words
The process of claim 1, comprising the additional step of rendering the measurement solution substantially oxygen-free by passing it through a catalytic reactor in step (a) prior to passing it through the measuring cell.
Claim 4
Dependent Claim
23 words
The process of claim 2, wherein the catalytic reactor comprises a transition metal selected from the group consisting of platinum, iridium and palladium.
Claim 5
Dependent Claim
14 words
The process of claim 3, wherein the catalytic reactor comprises platinum supported on alumina.
Claim 6
Dependent Claim
14 words
The process of claim 1, wherein the measurement solution is an aqueous alcohol solution.
Claim 7
Dependent Claim
22 words
The process of claim 5, wherein the aqueous alcohol solution is an alkaline aqueous solution of a primary alcohol in deionized water.
Claim 8
Dependent Claim
15 words
The process of claim 1, wherein the measuring cell is a thin layer volumetric cell.
Claim 9
Independent Claim
145 words
An apparatus for determining pO 2 in a blood sample, comprising a fluid circuit comprising (i) a source of a measurement solution having substantially zero pO 2 , (ii) a measuring cell for determining the value of an electrical quantity of the solution passing through the cell related to the pO 2 of the blood sample, and (iii) a diffusion cell divided into two chambers by a permeation membrane which is permeable to gasses but not to ions in which the solution is brought into static contact with the blood sample via said permeation membrane; means for propelling the solution from the source along the circuit past the measuring cell and to the diffusion cell, and for propelling the solution in the reverse direction to the measuring cell; and means for measuring the value of the electrical quantity of the solution in the measuring cell.
Claim 10
Independent Claim
145 words
An apparatus for determining pO 2 in a blood sample, comprising a fluid circuit comprising (i) a source of a measurement solution having substantially zero pO 2 , (ii) a measuring cell for determining the value of an electrical quantity of the solution passing through the cell related to the pO 2 of the blood sample, and (iii) a diffusion cell divided into two chambers by a permeation membrane which is permeable to gasses but not to ions in which the solution is brought into static contact with the blood sample via said permeation membrane; means for propelling the solution from the source along the circuit past the measuring cell and to the diffusion cell, and for propelling the solution in the reverse direction to the measuring cell; and means for measuring the value of the electrical quantity of the solution in the measuring cell.
Claim 11
Dependent Claim
35 words
The apparatus of claim 8, further comprising a catalytic reactor for rendering the measurement solution oxygen-free, said catalytic reactor being located in the fluid circuit between the source of measurement solution and the measuring cell.
Claim 12
Dependent Claim
23 words
The apparatus of claim 9, wherein the catalytic reactor comprises a transition metal selected from the group consisting of platinum, iridium and palladium.
Claim 13
Dependent Claim
14 words
The apparatus of claim 10, wherein the catalytic reactor comprises platinum supported on alumina.
Claim 14
Dependent Claim
14 words
The apparatus of claim 8, wherein the measurement solution is an aqueous alcohol solution.
Claim 15
Dependent Claim
21 words
The apparatus of claim 12, wherein the aqueous alcohol solution is an alkaline solution of a primary alcohol in deionized water.
Claim 16
Dependent Claim
14 words
The apparatus of claim 8, wherein the measuring cell is a thin-layer voltametric cell.
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