Method for preparing a powdered particulate composition

Claim 1

A process of manufacturing a powdered particulate comprising: dissolving (a) 1-5 parts by weight of the free base of a compound of the formula: ##STR2## in which X=carbon or nitrogen, Y=carbon or nitrogen, R 1 and R 2 are each independently selected from H, OH, O-alkyl (1-4 C atoms), alkyl (1-4 C atoms) and a halogen, R 3 =H or alkyl (1-4 C atoms), and the broken line indicates an extra bond that may be present when Y is a carbon atom, (b) 0.3-3 parts by weight of a cellulose derivative that is soluble in water and organic solvents, and (c) 4-20 parts by weight of a water insoluble pharmaceutically acceptable polymer in an organic solvent; and mixing with the solution formed (d) 40-250 parts by weight of a pharmaceutical filler distinct from said cellulose derivative and also distinct from said water insoluble pharmaceutically acceptable polymer and granulating said mixture, wherein the amount of organic solvent used is an amount of solvent effective for dissolving the compound, cellulose derivative and polymer and for granulating the solution formed with the pharmaceutical filler.