US4834985A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release pharmaceutical composition
Assignee: Purdue Pharma LP
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Filing: 1987-05-19
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Granted: 1989-05-30
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Expires: 2007-05-19
Abstract
Abstract A solid, controlled release, pharmaceutical composition comprising an active ingredient incorporated in a matrix comprising a first substance selected from a water soluble polydextrose and a water soluble cyclodextrin and a second substance selected from a C 12 -C 36 fatty alcohol and a polyalkylene glycol. Preferably the first substance is a cyclodextrin, especially a beta-cyclodextrin, while the second substance is a C 14 -C 22 fatty alcohol, especially stearyl alcohol, cetyl alcohol, cetostearyl alcohol or myristyl alcohol. The matrix may also contain a cellulose ether, especially a hydroxyalkylcellulose or a carboxyalkylcellulose.
Inventors
- 👤 Gordon Elger
- 👤 Stewart T. Leslie
- 👤 Sandra T. A. Malkowska
- 👤 Ronald B. Miller
- 👤 Philip J. Neale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:18
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2013; A61K9/2031
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
58 words
A solid, controlled release pharmaceutical composition comprising a pharmaceutically active ingredient incorporated in a matrix comprising a first substance selected from the group consisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C 12 -C 36 fatty alcohol and a polyalkylene glycol.
Claim 2
Dependent Claim
58 words
A solid, controlled release pharmaceutical composition comprising a pharmaceutically active ingredient incorporated in a matrix comprising a first substance selected from the group consisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C 12 -C 36 fatty alcohol and a polyalkylene glycol.
Claim 3
Dependent Claim
13 words
The composition according to claim 1 wherein the first substance is a cyclodextrin.
Claim 4
Dependent Claim
13 words
The composition according to claim 2 wherein the first substance is a beta-cyclodextrin.
Claim 5
Dependent Claim
18 words
The composition according to claim 1 wherein the fatty alcohol is a C 14 -C 22 fatty alcohol.
Claim 6
Dependent Claim
26 words
The composition according to claim 1 wherein the fatty alcohol is selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol and myristyl alcohol.
Claim 7
Dependent Claim
13 words
The composition according to claim 1 wherein the polyalkylene glycol is polyethylene glycol.
Claim 8
Dependent Claim
14 words
The composition according to claim 1 wherein the first substance is a cellulose ether.
Claim 9
Dependent Claim
20 words
The composition according to claim 7 wherein the cellulose ether is at least one of a hydroxyalkylcellulose and a carboxyalkylcellulose.
Claim 10
Dependent Claim
26 words
The composition according to claim 1 wherein the ratio of the first substance to the second substance is between 6 to 1 and 1 to 6.
Claim 11
Dependent Claim
18 words
The composition according to claim 9 wherein the ratio is between 4 to 1 and 1 to 4.
Claim 12
Dependent Claim
19 words
The composition according to claim 1 wherein the composition contains between 1% and 80% (w/w) of the first substance.
Claim 13
Dependent Claim
19 words
The composition according to claim 11 wherein the composition contains between 1% and 50% (w/w) of the first substance.
Claim 14
Dependent Claim
19 words
The composition according to claim 12 wherein the composition contains between 2% and 40% (w/w) of the first substance.
Claim 15
Dependent Claim
15 words
The composition according to claim 1 wherein the active ingredient is a water isoluble drug.
Claim 16
Dependent Claim
69 words
A preparation in which a pharmaceutically active ingredient can be incorporated for the production of a solid, controlled release, pharmaceutical composition, said preparation comprising a matrix of a first substance selected from the group consisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C 12 -C 36 fatty alcohol and a polyalkylene glycol.
Claim 17
Dependent Claim
69 words
A preparation in which a pharmaceutically active ingredient can be incorporated for the production of a solid, controlled release, pharmaceutical composition, said preparation comprising a matrix of a first substance selected from the group consisting of a water soluble polydextrose, a water soluble cyclodextrin and a cellulose ether, and a second substance selected from the group consisting of a C 12 -C 36 fatty alcohol and a polyalkylene glycol.
Claim 18
Dependent Claim
13 words
The preparation according to claim 15 wherein the first substance is a cyclodextrin.
Claim 19
Dependent Claim
13 words
The preparation according to claim 16 wherein the first substance is a beta-cyclodextrin.
Claim 20
Dependent Claim
18 words
The preparation according to claim 15 wherein the fatty alcohol is a C 14 -C 22 fatty alchol.
Claim 21
Dependent Claim
26 words
The preparation according to claim 18 wherein the fatty alcohol is selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol and myristyl alcohol.
Claim 22
Dependent Claim
13 words
The preparation according to claim 15 wherein the polyalkylene glycol is polyethylene glycol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-29 | 1992-11-28 | 1993-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-29 | 1996-11-28 | 1997-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-29 | 2000-11-28 | 2001-05-30 | $7700.00 | Window Closed / Lapsed |