US3922339A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release medicant
Assignee: Kv Pharmaceutical Co
•
Filing: 1974-06-20
•
Granted: 1975-11-25
•
Expires: 1994-06-20
Abstract
Abstract This invention relates to a sustained release pharmaceutical preparation of a medicant prepared by 1. Compacting a wet pharmaceutical preparation; 2. Drying and granulating the compacted preparations of (1); 3. Sealing the granules of (2); 4. Coating (3) with an enteric-soluble coating. The medicant employed in the pharmaceutical preparation is preferably blended with an inert material.
Inventors
- 👤 Jeff L Shear
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
112 words
A PROCESS OF PREPARING A SUBSTAINED RELEASE PHARMACEUTICAL PREPARATION OF A MEDICANT WHICH COMPRISES (1) BLENDING A MEDICANT WITH DESIRED MATERIAL; (2) WETTING THE BLEND WITH SUFFICIENT LIQUID MATERIAL SO AS TO ACT AS A BINDER ON COMPACTING; (3) COMPACTING THE WETTED BLEND BY EXTRUDING TO FORM A SPAGHETTI-LIKE MATERIAL; (4) DRYING, BREAKING AND SCREENING THE EXTRUDED MATERIAL; (4) DRYING, BREAKING AND (5) SPRAYING THE PARTICLES WITH A SOLUTION OF A FILM-FORMING MATERIAL; (6) DUSTING THE PARTICLES WITH A POWDER AND DRYING TO FORM A SEAL ON THE PARTICLES; AND (7) COATING THE SEALED PARTICLES WITH A SOLUTION OF AN EXCIPIENT SO AS TO FORM AN ELECTRIC-SOLUBLE COATING ON THE SEALED PARTICLE.
Claim 2
Dependent Claim
112 words
A PROCESS OF PREPARING A SUBSTAINED RELEASE PHARMACEUTICAL PREPARATION OF A MEDICANT WHICH COMPRISES (1) BLENDING A MEDICANT WITH DESIRED MATERIAL; (2) WETTING THE BLEND WITH SUFFICIENT LIQUID MATERIAL SO AS TO ACT AS A BINDER ON COMPACTING; (3) COMPACTING THE WETTED BLEND BY EXTRUDING TO FORM A SPAGHETTI-LIKE MATERIAL; (4) DRYING, BREAKING AND SCREENING THE EXTRUDED MATERIAL; (4) DRYING, BREAKING AND (5) SPRAYING THE PARTICLES WITH A SOLUTION OF A FILM-FORMING MATERIAL; (6) DUSTING THE PARTICLES WITH A POWDER AND DRYING TO FORM A SEAL ON THE PARTICLES; AND (7) COATING THE SEALED PARTICLES WITH A SOLUTION OF AN EXCIPIENT SO AS TO FORM AN ELECTRIC-SOLUBLE COATING ON THE SEALED PARTICLE.
Claim 3
Dependent Claim
15 words
The process of claim 1 wherein the medicant comprises 5-95% of the medicant-inert material blend.
Claim 4
Dependent Claim
15 words
The process of claim 1 where the medicant comprises 30-50% of the medicant-inert material blend.
Claim 5
Dependent Claim
29 words
The process of claim 1 where the inert material is a mixture of 25% starch and 75% sugar and there is 1 part medicant to 2 parts inert material.
Claim 6
Dependent Claim
13 words
The process of claim 1 where medicant-inert material blend is wetted with water.
Claim 7
Dependent Claim
27 words
The process of claim 1 where the wetted blend is extruded through an orifice having a diameter of 1/16 of an inch to form the spaghetti-like material.
Claim 8
Dependent Claim
20 words
The process of claim 1 where the dried and broken extruded material is screened to about a 16-24 mesh size.
Claim 9
Dependent Claim
35 words
The process of claim 1 where the screened particles are sprayed with an 89% aqueous solution of sugar, as the film-forming material, in a ratio of 9 parts aqueous solution to 100 parts of particles.
Claim 10
Dependent Claim
26 words
The process of claim 1 where the sprayed particles are dusted with powdered talc in a ratio of 10 parts talc per 100 parts of particles.
Claim 11
Dependent Claim
39 words
The process of claim 1 where the sealed particles are ccated with 14 parts of a 36% alcoholic solution of shellac to 100 parts of particles and then dusted with 25 parts stearic acid per 100 parts sealed particles.
Claim 12
Dependent Claim
17 words
The process of claim 1 where the sealed particles are coated with a calcium stearate/talc enteric coating.
Claim 13
Dependent Claim
14 words
The process of claim 1 where the enteric coating step is repeated three times.
Claim 14
Dependent Claim
14 words
The process of claim 10 where the enteric coating step is repeated three times.
Claim 15
Dependent Claim
14 words
The process of claim 12 where the enteric coating step is repeated three times.
Claim 16
Dependent Claim
9 words
The product obtained by tHe process of claim 1.
Claim 17
Dependent Claim
9 words
The product obtained by the process of claim 10.
References Cited (Backward Citations)
US2811483A
Cited
US2895880A
Cited
US3247064A
Cited
US3115441A
Cited
US3361631A
Cited
US3480468A
Cited
US3524756A
Cited
US3555144A
Cited
US3646192A
Cited
US3728445A
Cited
US3758679A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-24 | 1979-05-26 | 1979-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-24 | 1983-05-26 | 1983-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-24 | 1987-05-26 | 1987-11-25 | $7700.00 | Window Closed / Lapsed |