Patent US5237101A successfully refreshed from Google Patents.
US5237101A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Propargylic and allenic sulfones
Assignee: TRUSTEES OF UNIVERSITY OF PENNSYLVANIA A NON PROFIT CORP OF
•
Filing: 1990-01-26
•
Granted: 1993-08-17
•
Expires: 2010-01-26
Abstract
Abstract Propargylic and allenic sulfones are disclosed having the ability to selectively cleave nucleic acids, especially deoxyribonucleic acid. Such compositions are capable of being synthetically modified to effect cleavage at selected, sequenced sites on nucleic acids.
Inventors
- 👤 K. C. Nicolaou
- 👤 Guido Zaccarello
- 👤 Golfo Skokotas
- 👤 Peter Maligres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:35
CPC Classifications
C; C07; C07C; C07C317/00; C07C317/16; C07C317/22; C07C317/18; C07D; C07D337/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
124 words
A chemical compound having the structure: ##STR8## wherein R 1 , R 2 , and R 3 are independently hydrogen, hydroxyl, alkyl moieties having from about 1 to about 10 carbon atoms, and aryl moieties having 11 to about 18 carbon atoms, CH 2 OC(O)Ch 3 , C(O)NHR 8 , (CH 2 n OH, (CH 2 n O-saccharides, (CH 2 ) n O-DNA intercalators, (CH 2 ) n O-DNA minor groove binders, (CH 2 ) n )O-DNA binding proteins, (CH 2 ) n O-DNA fragments, (CH 2 ) n )O-RNA fragments, or (CH 2 ) n O-antibodies, R 8 is selected from the group consisting of saccharides, DNA intercalators, DNA minor groove binders, DNA binding proteins, DNA fragments, RNA fragments, or antibodies and n=1-10.
Claim 2
Dependent Claim
124 words
A chemical compound having the structure: ##STR8## wherein R 1 , R 2 , and R 3 are independently hydrogen, hydroxyl, alkyl moieties having from about 1 to about 10 carbon atoms, and aryl moieties having 11 to about 18 carbon atoms, CH 2 OC(O)Ch 3 , C(O)NHR 8 , (CH 2 n OH, (CH 2 n O-saccharides, (CH 2 ) n O-DNA intercalators, (CH 2 ) n O-DNA minor groove binders, (CH 2 ) n )O-DNA binding proteins, (CH 2 ) n O-DNA fragments, (CH 2 ) n )O-RNA fragments, or (CH 2 ) n O-antibodies, R 8 is selected from the group consisting of saccharides, DNA intercalators, DNA minor groove binders, DNA binding proteins, DNA fragments, RNA fragments, or antibodies and n=1-10.
Claim 3
Dependent Claim
22 words
The chemical compound of claim 1 wherein R 1 is anthryl, R 2 is CH 2 OH and R 3 is hydrogen.
Claim 4
Dependent Claim
17 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is hydrogen.
Claim 5
Dependent Claim
17 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is hydroxyl.
Claim 6
Dependent Claim
27 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is an alkyl moiety having from 1 to about 10 carbon atoms.
Claim 7
Dependent Claim
26 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is an aryl moiety having 11 to about 18 carbon atoms.
Claim 8
Dependent Claim
21 words
The compound of calim 1 wherein R 1 , R 2 , or R 3 is CH 2 OC(O)CH 3 .
Claim 9
Dependent Claim
21 words
The compound of calim 1 wherein R 1 , R 2 , or R 3 is CH 2 OC(O)CH 3 .
Claim 10
Dependent Claim
18 words
The compound of claim 1 wherein R 1 , R 2 or R 3 is C(O)NHR 8 .
Claim 11
Dependent Claim
21 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n OH.
Claim 12
Dependent Claim
21 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-saccharide.
Claim 13
Dependent Claim
22 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-DNA intercalator.
Claim 14
Dependent Claim
24 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-DNA minor groove binder.
Claim 15
Dependent Claim
23 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-DNA binding protein.
Claim 16
Dependent Claim
29 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-DNA fragment or (CH 2 ) n O-RNA fragment.
Claim 17
Dependent Claim
21 words
The compound of claim 1 wherein R 1 , R 2 , or R 3 is (CH 2 ) n O-antibody.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-16 | 1997-02-15 | 1997-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-16 | 2001-02-15 | 2001-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-16 | 2005-02-15 | 2005-08-17 | $7700.00 | Window Closed / Lapsed |