US5234808A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acetate addition to platelets stored in plasma
Assignee: Thomas Jefferson University
•
Filing: 1991-10-30
•
Granted: 1993-08-10
•
Expires: 2011-10-30
Abstract
Abstract The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding acetate to a platelet concentrate.
Inventors
- 👤 Scott Murphy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:14
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
67 words
A method of storing a human blood platelet preparation consisting essentially of: providing a human blood, plasma-based platelet concentrate comprising platelets suspended in a solution consisting essentially of plasma, the pH of the preparation being at least 6.1; and adding acetate to the platelet concentrate in an amount sufficient to reduce the pH fall of the preparation and to maintain the pH of the preparation above 6.1.
Claim 2
Independent Claim
67 words
A method of storing a human blood platelet preparation consisting essentially of: providing a human blood, plasma-based platelet concentrate comprising platelets suspended in a solution consisting essentially of plasma, the pH of the preparation being at least 6.1; and adding acetate to the platelet concentrate in an amount sufficient to reduce the pH fall of the preparation and to maintain the pH of the preparation above 6.1.
Claim 3
Dependent Claim
31 words
The method of claim 1 wherein the step of adding the acetate is performed so as to ensure that the amount of acetate in the platelet preparation is about 20 mM.
Claim 4
Dependent Claim
22 words
The method of claim 1 further comprising maintaining the pH of the platelet preparation above 6.8 for a period of 12 days.
Claim 5
Dependent Claim
32 words
The method of claim 1 wherein the step of adding the acetate is performed so as to ensure that the amount of acetate in the platelet preparations is from about 17-20 mM.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-09 | 1997-02-08 | 1997-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-09 | 2001-02-08 | 2001-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-09 | 2005-02-08 | 2005-08-10 | $7700.00 | Window Closed / Lapsed |