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US5225404A
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Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
Assignee: Christus Stehlin Foundation for Cancer Research
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Filing: 1989-11-06
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Granted: 1993-07-06
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Expires: 2009-11-06
Abstract
Abstract The present invention provides methods of treating malignant colon and colo-rectal cancer in mammals, by reducing or inhibiting or retarding such colon cancer tumors in mammals. These methods employ the administration of a tumor-inhibiting or reducing camptothecin compound, e.g., 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin, and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof. Also provided are pharmaceutical formulations.
Inventors
- 👤 Beppino C. Giovannella
- 👤 Leroy F. Liu
- 👤 Milan Potmesil
- 👤 Monroe C. Wall
- 👤 Robert F. Silber
- 👤 Mansukh C. Wani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:13
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
52 words
A method of treating malignant colon tumors in a mammal in need of such treatment which comprises administering to said mammal an effective amount for treating said tumor of a tumor inhibiting camptothecin compound selected from the group consisting of 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.
Claim 2
Independent Claim
52 words
A method of treating malignant colon tumors in a mammal in need of such treatment which comprises administering to said mammal an effective amount for treating said tumor of a tumor inhibiting camptothecin compound selected from the group consisting of 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.
Claim 3
Dependent Claim
13 words
The method according to claim 1 wherein said colon tumors comprise colo-rectal tumors.
Claim 4
Dependent Claim
14 words
The method according to claim 1 wherein said tumor inhibiting camptothecin compound comprises 9-amino-20(RS)-camptothecin.
Claim 5
Dependent Claim
14 words
The method according to claim 1 wherein said tumor inhibiting camptothecin compound comprises 10,11-methylenedioxy-20(RS)-camptothecin.
Claim 6
Dependent Claim
17 words
The method according to claim 1 wherein said tumor inhibiting compound comprises the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin.
Claim 7
Dependent Claim
31 words
The method according to claim 1 wherein said effective amount comprises from about 2 mg/per kg of body weight per week to about 35 mg/per kg of body weight per week.
Claim 8
Dependent Claim
47 words
The method according to claim 6 which comprises dividing said effective amount into doses to be administered more than once a week but wherein the total dosage administered per week is from about 2 mg/per kg of body weight to about 35 mg/per kg of body weight.
Claim 9
Dependent Claim
20 words
The method according to claim 6 which comprises administering said effective amount in divided doses about two times per week.
Claim 10
Dependent Claim
17 words
The method according to claim 1 which comprises parenteral administering said tumor inhibiting camptothecin compound said mammal.
Claim 11
Dependent Claim
19 words
The method according to claim 9 wherein said parenteral administration of the tumor inhibiting camptothecin compound comprises subcutaneous injection.
Claim 12
Independent Claim
34 words
A method for retarding a colo-rectal tumor in a mammal in need of such treatment which comprises administering to said mammal an effective amount for retarding said tumor of a colo-rectal inhibiting camptothecin compound.
Claim 13
Independent Claim
34 words
A method for retarding a colo-rectal tumor in a mammal in need of such treatment which comprises administering to said mammal an effective amount for retarding said tumor of a colo-rectal inhibiting camptothecin compound.
Claim 14
Dependent Claim
39 words
A pharmaceutical formulation comprising an effective amount for inhibiting the growth of a colon tumor of a colon tumor-inhibiting camptothecin compound selected from the group consisting of 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.
Claim 15
Dependent Claim
39 words
A pharmaceutical formulation comprising an effective amount for inhibiting the growth of a colon tumor of a colon tumor-inhibiting camptothecin compound selected from the group consisting of 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.
Claim 16
Dependent Claim
12 words
The pharmaceutical formulation according to claim 12 wherein said compound comprises 9-amino-20(RS)-camptothecin.
Claim 17
Dependent Claim
20 words
The pharmaceutical formulation according to claim 12 comprising from about 100 mg to about 500 mg of said camptothecin compound.
Claim 18
Dependent Claim
12 words
The pharmaceutical formulation according to claim 12 comprising a parenteral dosage form.
Claim 19
Dependent Claim
23 words
The pharmaceutical formulation according to claim 12 comprising an oral dosage form selected from the group consisting of a tablet and a capsule.
Claim 20
Independent Claim
52 words
A method of treating malignant colon tumors in a mammal in need of such treatment which comprises administering to said mammal an effective amount for treating said tumor of a tumor inhibiting camptothecin compound selected from the group consisting of 9-amino-20(S)-camptothecin, 10,11-methylenedioxy-20(S)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(S)-camptothecin, or a combination thereof.
Claim 21
Independent Claim
52 words
A method of treating malignant colon tumors in a mammal in need of such treatment which comprises administering to said mammal an effective amount for treating said tumor of a tumor inhibiting camptothecin compound selected from the group consisting of 9-amino-20(S)-camptothecin, 10,11-methylenedioxy-20(S)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(S)-camptothecin, or a combination thereof.
Claim 22
Dependent Claim
13 words
The method according to claim 17 wherein said colon tumors comprise colo-rectal tumors.
Claim 23
Dependent Claim
14 words
The method according to claim 17 wherein said tumor inhibiting camptothecin compound comprises 9-amino-20(S)-camptothecin.
Claim 24
Dependent Claim
14 words
The method according to claim 17 wherein said tumor inhibiting camptothecin compound comprises 10,11-methylenedioxy-20(S)-camptothecin.
Claim 25
Dependent Claim
17 words
The method according to claim 17 wherein said tumor inhibiting compound comprises the sodium salt of 10,11-methylenedioxy-20(S)-camptothecin.
Claim 26
Dependent Claim
31 words
The method according to claim 17 wherein said effective amount comprises from about 2 mg/per kg of body weight per week to about 35 mg/per kg of body weight per week.
Claim 27
Dependent Claim
47 words
The method according to claim 22 which comprises dividing said effective amount into doses to be administered more than once a week but wherein the total dosage administered per week is from about 2 mg/per kg of body weight to about 35 mg/per kg of body weight.
Claim 28
Dependent Claim
19 words
The method according to claim 22 which comprises administering said effective amount in divided doses two times per week.
Claim 29
Dependent Claim
18 words
The method according to claim 17 which comprises parenterally administering said tumor inhibiting camptothecin compound to said mammal.
Claim 30
Dependent Claim
13 words
The method according to claim 25 wherein said parenteral administration comprises subcutaneous injection.
Claim 31
Dependent Claim
39 words
A pharmaceutical formulation comprises an effective amount for inhibiting the growth of a colon tumor of a colon tumor-inhibiting camptothecin compound selected from the group consisting of 9-amino-20(S)-camptothecin, 10,11-methylenedioxy-20(S)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(S)-camptothecin, or a combination thereof.
Claim 32
Dependent Claim
39 words
A pharmaceutical formulation comprises an effective amount for inhibiting the growth of a colon tumor of a colon tumor-inhibiting camptothecin compound selected from the group consisting of 9-amino-20(S)-camptothecin, 10,11-methylenedioxy-20(S)-camptothecin and the sodium salt of 10,11-methylenedioxy-20(S)-camptothecin, or a combination thereof.
Claim 33
Dependent Claim
12 words
The pharmaceutical formulation according to claim 27 wherein said compound comprises 9-amino-20(S)-camptothecin.
Claim 34
Dependent Claim
20 words
The pharmaceutical formulation according to claim 27 comprising from about 100 mg to about 500 mg of said camptothecin compound.
Claim 35
Dependent Claim
12 words
The pharmaceutical formulation according to claim 27 comprising a parenteral dosage form.
Claim 36
Dependent Claim
23 words
The pharmaceutical formulation according to claim 27 comprising an oral dosage form selected from the group consisting of a tablet and a capsule.
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