Patent US5223284A successfully refreshed from Google Patents.
US5223284A
Expired / Lapsed
US
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Products and methods for treating colic
Assignee: Washington University in St. Louis
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Filing: 1991-05-22
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Granted: 1993-06-29
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Expires: 2011-05-22
Abstract
Abstract The present invention provides products, processes and/or methods for treating or preventing the clinical symptoms of an infant suffering from colic. Products and/or methods which reduce or eliminate the level of bovine IgG in food products are also useful to treat patients experiencing clinical symptoms related to ingesting bovine food products.
Inventors
- 👤 Anthony Kulczycki, Jr.
- 👤 Patrick S. Clyne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:49
CPC Classifications
A; A23; A23J; A23J1/00; A23J1/20; A23J1/205; A23C; A23C21/00; A23C21/02; A23C9/00; A23C9/14; A23C9/146; A23C9/1465; A23C9/15; A23C9/1512; A23C9/20; A23V; A23V2002/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
110 words
A process for reducing the bovine IgG content of a cow's milk product having both whey components and casein components consisting essentially of the following steps: a) separating the whey components of the cow's milk product from the casein components; b) treating a liquid solution of said whey components to reduce the IgG content thereof to a level of less than about 20 μg/ml, based on the volume of the cow's milk product wherein said treating does not substantially alter any milk-containing proteins in said liquid solution of whey components other than bovine IgG; and c) recombining the treated whey components with at least a portion of said casein components.
Claim 2
Dependent Claim
110 words
A process for reducing the bovine IgG content of a cow's milk product having both whey components and casein components consisting essentially of the following steps: a) separating the whey components of the cow's milk product from the casein components; b) treating a liquid solution of said whey components to reduce the IgG content thereof to a level of less than about 20 μg/ml, based on the volume of the cow's milk product wherein said treating does not substantially alter any milk-containing proteins in said liquid solution of whey components other than bovine IgG; and c) recombining the treated whey components with at least a portion of said casein components.
Claim 3
Dependent Claim
46 words
The process of claim 1 wherein said treating step b comprises: i) adding a food grade polyatomic salt to said liquid solution of whey components; ii) separating precipitated bovine IgG from said solution; and iii) removing any polyatomic salt remaining in said liquid solution by dialysis.
Claim 4
Dependent Claim
32 words
The process of claim 2 wherein the polyatomic salt is selected from the group consisting of: aluminum ammonium sulfate, sodium tartrate, sodium phosphate, potassium phosphate, sodium citrate, sodium sulfate or combinations thereof.
Claim 5
Dependent Claim
29 words
The process of claim 1 wherein said treating step b comprises contacting said liquid solution of whey components with an ion exchange resin having an affinity for bovine IgG.
Claim 6
Dependent Claim
29 words
The process of claim 1 wherein said treating step b comprises contacting said liquid solution of whey components with a bacterial protein which is coupled to a solid-phase support.
Claim 7
Dependent Claim
12 words
The process of claim 5 wherein said bacterial protein is protein G.
Claim 8
Dependent Claim
33 words
The process of claim 1 wherein said treating step b comprises contacting said liquid solution of whey components with an antibody to bovine IgG, wherein said antibody is coupled to a solid-phase support.
Claim 9
Dependent Claim
25 words
The process of claim 1 wherein said treating step b comprises contacting said liquid solution of whey components with an enzyme for digesting bovine IgG.
Claim 10
Dependent Claim
24 words
The process of claim 1 wherein said treating step b comprises heating said liquid solution of whey components to denature the bovine IgG protein.
Claim 11
Dependent Claim
20 words
The process of claim 1 wherein said IgG content is reduced to a level of less than about 2 μg/ml.
Claim 12
Dependent Claim
20 words
The process of claim 1 wherein said IgG content is reduced to a level of less than about 0.6 μg/ml.
Claim 13
Dependent Claim
20 words
The process of claim 1 wherein said IgG content is reduced to a level of less than about 0.22 μg/ml.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |