Patent EP0580474A1 successfully refreshed from Google Patents.
Patent US5223269A successfully refreshed from Google Patents.
US5223269A
Expired / Lapsed
US
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Methods and composition for the treatment of hypertension
Assignee: Individual
•
Filing: 1991-05-15
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Granted: 1993-06-29
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Expires: 2011-05-15
Abstract
Abstract Methods and compositions of a deuterium-containing compound are disclosed that are utilized in the treatment of hypertension. Compositions containing deuterium oxide, deuterated foods or deuterated antihypertensive drugs dissolved or dispersed in a physiologically tolerable diluent are administered to patients in need of treatment for hypertensive disorders. Methods for the lowering of elevated blood pressure and for decreasing the likelihood of the onset of hypertension in a patient are disclosed.
Inventors
- 👤 Andrejs Liepins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:36
CPC Classifications
A; A61; A61K; A61K33/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
67 words
A method of treatment for hypertension in a patient comprising administering to said patient exhibiting an elevated blood pressure a therapeutically effective amount of deuterium oxide contained in water in an amount in the range of about 10 weight percent to about 90 weight percent based on the weight of water for a time period sufficient to effect a reduction of said blood pressure in said patient.
Claim 2
Independent Claim
67 words
A method of treatment for hypertension in a patient comprising administering to said patient exhibiting an elevated blood pressure a therapeutically effective amount of deuterium oxide contained in water in an amount in the range of about 10 weight percent to about 90 weight percent based on the weight of water for a time period sufficient to effect a reduction of said blood pressure in said patient.
Claim 3
Dependent Claim
14 words
The method in accordance with claim 1, wherein said deuterium-containing composition is administered orally.
Claim 4
Dependent Claim
28 words
The method in accordance with claim 1, wherein said administration is continued so as to maintain a reduction in systolic blood pressure of at least about 10 percent.
Claim 5
Dependent Claim
26 words
The method in accordance with claim 1, wherein said administration is continued at least until an equilibrium deuteration of the patient's body fluids has been attained.
Claim 6
Dependent Claim
22 words
The method in accordance with claim 1, wherein said administration is continued for a time period of at least about 14 days.
Claim 7
Dependent Claim
30 words
The method in accordance with claim 1, wherein the deuterium oxide is contained in water in an amount of about 22.5 to about 25 percent by weight of the water.
Claim 8
Dependent Claim
25 words
The method in accordance with claim 1, wherein said deuterium-containing composition is deuterium oxide contained in physiological saline and wherein said composition is administered intravenously.
Claim 9
Independent Claim
49 words
A method of decreasing the likelihood of the onset of hypertension in a patient at risk for hypertension which comprises administering to said patient about 12 grams to about 675 grams of deuterium oxide per day, and wherein the administration is continued daily while said patient remains at risk.
Claim 10
Independent Claim
49 words
A method of decreasing the likelihood of the onset of hypertension in a patient at risk for hypertension which comprises administering to said patient about 12 grams to about 675 grams of deuterium oxide per day, and wherein the administration is continued daily while said patient remains at risk.
Claim 11
Dependent Claim
14 words
The method in accordance with claim 8, wherein said deuterium oxide is administered orally.
Claim 12
Dependent Claim
21 words
The method in accordance with claim 8, wherein said deuterium oxide is contained in deuterated physiological saline and is administered intravenously.
References Cited (Backward Citations)
US4002663A
Cited
US4259523A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |