US5222982A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Spinal fluid driven artificial organ
Assignee: Individual
•
Filing: 1992-02-25
•
Granted: 1993-06-29
•
Expires: 2012-02-25
Abstract
Abstract The present invention concerns a spinal fluid driven artificial organ device and methods for its use. The device has a tripartite chamber with three sections. A micropore filter ("B") separates chamber section 1 from chamber section 2 and a micropore filter ("C") separates chamber section 2 from chamber section 3. CSF enters chamber section 1 via an inlet tube (T.i.) and an one way value (V1). Micropore filter "B" allows entry of CSF into chamber section 2 but does not allow exit of any cells from chamber section 2 into chamber section 1. Micropore filter "C" allows free passage of CSF from chamber section 2 into chamber section 3 and prevents any cells in chamber section 2 from entering chamber section 3. The CSF flow exits chamber section 3 via an one way valve (V2) and an outlet tube (T.o.). The outlet tube (T.o.) delivers the CSF to the desired location.
Inventors
- 👤 Ayub K. Ommaya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:27
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/022; A61M; A61M2202/00; A61M2202/04; A61M27/00; A61M27/002
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
173 words
A passive spinal fluid driven artificial organ device for delivering a biologically active product to a human or mammal, comprising an organ chamber divided into at least three sections with at least two filters to separate said sections from each other, a first section of said organ chamber adapted to receive at least one type of product-secreting cells, a second section of said organ chamber having an inlet tube and an one way valve for passage of spinal fluid into said second section, and a third section of said organ chamber having an outlet tube and an one way valve for outward flow of said spinal fluid and the products of said product-secreting cells, whereby said spinal fluid entering and flowing through said second, first and third sections, respectively, acts as a nutrient medium for said product-secreting cells and causes the passage of said products of said product-secreting cells out of said organ device, and wherein said filters allow unimpeded flow of said spinal fluid while retaining said cells in said first section.
Claim 2
Dependent Claim
173 words
A passive spinal fluid driven artificial organ device for delivering a biologically active product to a human or mammal, comprising an organ chamber divided into at least three sections with at least two filters to separate said sections from each other, a first section of said organ chamber adapted to receive at least one type of product-secreting cells, a second section of said organ chamber having an inlet tube and an one way valve for passage of spinal fluid into said second section, and a third section of said organ chamber having an outlet tube and an one way valve for outward flow of said spinal fluid and the products of said product-secreting cells, whereby said spinal fluid entering and flowing through said second, first and third sections, respectively, acts as a nutrient medium for said product-secreting cells and causes the passage of said products of said product-secreting cells out of said organ device, and wherein said filters allow unimpeded flow of said spinal fluid while retaining said cells in said first section.
Claim 3
Dependent Claim
13 words
The device according to claim 1, wherein said cells are pancreatic islet cells.
Claim 4
Dependent Claim
28 words
The device according to claim 1, wherein the exterior surface of said device has a ridge substantially defining the location of said first section within said organ chamber.
Claim 5
Dependent Claim
14 words
The device according to claim 1, wherein said filters have about 1-5 μ pores.
Claim 6
Dependent Claim
13 words
The device according to claim 1, wherein said cells are substantia nigra cells.
Claim 7
Dependent Claim
53 words
A method for treating disease in humans and mammals, comprising utilizing the device according to claim 1 wherein said inlet tube is connected to a spinal fluid source and said outlet tube is connected to said spinal fluid source or any part of the body that requires said product of said product-secreting cells.
Claim 8
Dependent Claim
12 words
The method according to claim 6, wherein said disease is diabetes mellitus.
Claim 9
Dependent Claim
11 words
The method according to claim 6, wherein said disease is Parkinsonism.
Claim 10
Dependent Claim
18 words
The method according to claim 6, wherein said device is placed subcutaneously in said human or said mammal.
References Cited (Backward Citations)
DE2225862A1
Cited
US4201845A
Cited
US4479796A
Cited
US4559299A
Cited
EP0155237A2
Cited
WO1986006094A1
Cited
US4878913A
Cited
US4892538A
Cited
US5026650A
Cited
US5011472A
Cited
US4954251A
Cited
EP0398083A1
Cited
EP0421380A1
Cited
JPH03224474A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |