Patent US5209720A successfully refreshed from Google Patents.
US5209720A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
Assignee: ImaRx Therapeutics Inc
•
Filing: 1991-06-18
•
Granted: 1993-05-11
•
Expires: 2011-06-18
Abstract
Abstract Gas filled liposomes prepared by a vacuum drying gas instillation method and/or gas filled liposomes substantially devoid of liquid in the interior thereof, are presented as novel potentiators for ultrasonic hyperthermia. The liposomes of the present invention, which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:33
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K41/00; A61K41/0028; A61K41/0052; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6925; A61K49/00; A61K49/22; A61K49/222; A61K49/223; A61K49/227; A61K9/1277; A61K9/1278; A61N; A61N7/00; A61N7/02; A61B; A61B17/00; A61B2017/00681; A61B2017/00707; A61B2017/00716; A61B17/22; A61B2017/22082; A61B2017/22088; A61M; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61N2007/025
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
50 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator comprising gas filled liposomes prepared by a vacuum drying gas instillation method; and (ii) applying ultrasound to said tissue or fluid.
Claim 2
Independent Claim
50 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator comprising gas filled liposomes prepared by a vacuum drying gas instillation method; and (ii) applying ultrasound to said tissue or fluid.
Claim 3
Dependent Claim
50 words
A method of claim 1 wherein said liposomes are comprised of lipid materials selected from the group consisting of fatty acids, lysolipids, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidic acid, sphingomyelin, cholesterol, cholesterol hemisuccinate, tocopherol hemisuccinate, phosphatidylethanolamine, phosphatidylinositol, lysolipids, sphingomyelin, glycosphingolipids, glucolipids, glycolipids, sulphatides, lipids with ether and ester-linked fatty acids, and polymerized lipids.
Claim 4
Dependent Claim
12 words
A method of claim 2 wherein said liposomes are comprised of dipalmitoylphosphatidylcholine.
Claim 5
Dependent Claim
29 words
A method of claim 1 wherein said liposomes are filled with a gas selected from the group consisting of air, nitrogen, carbon dioxide, oxygen, argon, xenon, helium, and neon.
Claim 6
Dependent Claim
13 words
A method of claim 4 wherein said liposomes are filled with nitrogen gas.
Claim 7
Dependent Claim
14 words
A method of claim 1 wherein said liposomes are suspended in an aqueous medium.
Claim 8
Dependent Claim
13 words
A method of claim 6 wherein said aqueous medium is phosphate buffered saline.
Claim 9
Dependent Claim
27 words
A method of claim 1 wherein said liposomes are administered to tissue or fluid selected from the group consisting of tumor tissue, muscle tissue, and blood fluid.
Claim 10
Independent Claim
50 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator comprising gas filled liposomes substantially devoid of liquid in the interior thereof; and (ii) applying ultrasound to said tissue or fluid.
Claim 11
Independent Claim
50 words
A method for heat treating biological tissues and fluids which comprises: (i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator comprising gas filled liposomes substantially devoid of liquid in the interior thereof; and (ii) applying ultrasound to said tissue or fluid.
Claim 12
Dependent Claim
50 words
A method of claim 9 wherein said liposomes are comprised of lipid materials selected from the group consisting of fatty acids, lysolipids, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidic acid, sphingomyelin, cholesterol, cholesterol hemisuccinate, tocopherol hemisuccinate, phosphatidylethanolamine, phosphatidylinositol, lysolipids, sphingomyelin, glycosphingolipids, glucolipids, glycolipids, sulphatides, lipids with ether and ester-linked fatty acids, and polymerized lipids.
Claim 13
Dependent Claim
12 words
A method of claim 10 wherein said liposomes are comprised of dipalmitoylphosphatidylcholine.
Claim 14
Dependent Claim
29 words
A method of claim 9 wherein said liposomes are filled with a gas selected from the group consisting of air, nitrogen, carbon dioxide, oxygen, argon, xenon, helium, and neon.
Claim 15
Dependent Claim
13 words
A method of claim 12 wherein said liposomes are filled with nitrogen gas.
Claim 16
Dependent Claim
14 words
A method of claim 9 wherein said liposomes are suspended in an aqueous medium.
Claim 17
Dependent Claim
13 words
A method of claim 14 wherein said aqueous medium is phosphate buffered saline.
Claim 18
Dependent Claim
27 words
A method of claim 9 wherein said liposomes are administered to tissue or fluid selected from the group consisting of tumor tissue, muscle tissue, and blood fluid.
References Cited (Backward Citations)
US4162282A
Cited
WO1980000502A1
Cited
US4310505A
Cited
WO1981001526A1
Cited
US4657756A
Cited
US4533254A
Cited
US4586512A
Cited
US4646756A
Cited
US4900540A
Cited
US4728575A
Cited
US4658828A
Cited
US4620546A
Cited
US4921706A
Cited
US4689986A
Cited
US4865836A
Cited
US4737323A
Cited
US4728578A
Cited
US4893624A
Cited
US5088499A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-10 | 1996-11-09 | 1997-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-10 | 2000-11-09 | 2001-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-10 | 2004-11-09 | 2005-05-11 | $7700.00 | Window Closed / Lapsed |