US5206250A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bis-naphthalimides containing amide and thioamide linkers as anticancer agents
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1991-03-27
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Granted: 1993-04-27
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Expires: 2011-03-27
Abstract
Abstract There are provided novel bis-naphthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing such compounds.
Inventors
- 👤 Jung-Hui Sun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 01:08
CPC Classifications
C; C07; C07D; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/14; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
75 words
A compound of the formula: ##STR12## or a diastereomerically pure or racemate or a mixture of racemate and meso, pharmaceutically acceptable salts thereof, wherein: ##STR13## each R 1 and R 4 independently are H, CH 3 or CH 2 CH 3 ; R 2 and R 3 are H; each A independently is O or S; XS and Y independently are H or NO 2 , each p is 0; n is 2 or 3.
Claim 2
Dependent Claim
75 words
A compound of the formula: ##STR12## or a diastereomerically pure or racemate or a mixture of racemate and meso, pharmaceutically acceptable salts thereof, wherein: ##STR13## each R 1 and R 4 independently are H, CH 3 or CH 2 CH 3 ; R 2 and R 3 are H; each A independently is O or S; XS and Y independently are H or NO 2 , each p is 0; n is 2 or 3.
Claim 3
Dependent Claim
19 words
A compound of claim 1 wherein: A is O; and R 1 and R 4 are CH 3 .
Claim 4
Dependent Claim
8 words
The compound of claim 1 which is (S,S)-N,N'-1,3-propanediylbis[α-methyl-5-nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetamide.
Claim 5
Dependent Claim
19 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1.
Claim 6
Dependent Claim
19 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 2.
Claim 7
Dependent Claim
19 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of claim 3.
Claim 8
Dependent Claim
8 words
The compound of claim 1 which is (R,R)-N,N'-1,3-propanediylbis[α-methyl-5nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetamide.
Claim 9
Dependent Claim
19 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 7.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-04-26 | 1996-10-26 | 1997-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-26 | 2000-10-26 | 2001-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-26 | 2004-10-26 | 2005-04-27 | $7700.00 | Window Closed / Lapsed |