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US5204626A
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Method for nuclear magnetic resonance measurements on low concentration solutes in solvent
Assignee: Hitachi Healthcare Manufacturing Ltd
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Filing: 1991-08-29
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Granted: 1993-04-20
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Expires: 2011-08-29
Abstract
Abstract NMR signals of low concentration solutes are obtained with suppression of NMR signal of solvent by sequentially applying a first RF pulse sequence, a 180° RF pulse and a second RF pulse sequence to an object. Each of the first and second RF pulse sequence includes equally spaced RF pulses which have flip angles in accordance with binominal coefficients. Phase errors due to inhomogeneity of a static magnetic field are cancelled through the two-time application of equally spaced RF pulse sequence.
Inventors
- 👤 Yukari Onodera
- 👤 Etsuji Yamamoto
- 👤 Ryuichi Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:47
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/4838; G01R33/54; G01R33/56; G01R33/565; G01R33/56563
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
112 words
A nuclear magnetic resonance measuring method of an object placed in a space to which a static magnetic field having slight inhomogeneity is applied, said method comprising the steps of: applying a first equidistant radio frequency pulse sequence the phases of which are inversed sequentially and which has a flip angle ratio in accordance with a binominal coefficient, to said object; applying consecutively an inversion radio frequency pulse to said object; applying further a second equidistant radio frequency pulse sequence the phases of which are inversed sequentially and which has a flip angle ratio in accordance with a binominal coefficient, to said object; and measuring transverse magnetization signals resulting from said object.
Claim 2
Dependent Claim
112 words
A nuclear magnetic resonance measuring method of an object placed in a space to which a static magnetic field having slight inhomogeneity is applied, said method comprising the steps of: applying a first equidistant radio frequency pulse sequence the phases of which are inversed sequentially and which has a flip angle ratio in accordance with a binominal coefficient, to said object; applying consecutively an inversion radio frequency pulse to said object; applying further a second equidistant radio frequency pulse sequence the phases of which are inversed sequentially and which has a flip angle ratio in accordance with a binominal coefficient, to said object; and measuring transverse magnetization signals resulting from said object.
Claim 3
Dependent Claim
60 words
A nuclear magnetic resonance measuring method according to claim 1, wherein the sum of the first sum of the absolute value of the flip angle of each pulse of said first radio frequency pulse sequence and the second sum of the absolute value of the flip angle of each pulse of said second radio frequency pulse sequence is substantially π/2.
Claim 4
Dependent Claim
57 words
A nuclear magnetic resonance measuring method according to claim 1, wherein the first sum of the absolute value of the flip angle of each pulse of said first radio frequency pulse sequence is substantially equal to the second sum of the absolute value of the flip angle of each pulse of said second radio frequency pulse sequence.
Claim 5
Dependent Claim
21 words
A nuclear magnetic resonance measuring method according to claim 3, wherein each of said first and second sums is substantially π/4.
Claim 6
Dependent Claim
45 words
A nuclear magnetic resonance measuring method according to claim 1, wherein the number of pulses of said first radio frequency pulse sequence is equal to the number of pulses of said second radio frequency pulse sequence or has a difference of 1 from the latter.
Claim 7
Dependent Claim
94 words
A nuclear magnetic resonance measuring method according to claim 1, wherein each of said first and second pulse sequence is the pulse sequence which comprises even-numbered radio frequency pulses and has the same phase, said inversion radio frequency pulse and said second radio frequency pulses are consecutively applied after the passage of a predetermined time from completion of the application of said first radio frequency pulse sequence, and said inversion radio frequency pulse has the same phase as that of the pulses of either one of said first and second radio frequency pulse sequences.
Claim 8
Dependent Claim
91 words
A nuclear magnetic resonance measuring method according to claim 1, wherein each of said first and second pulse sequences is the pulse sequence which comprises odd-numbered radio frequency pulses and has the same phase, said inversion radio frequency pulse and said second radio frequency pulse sequence are consecutively applied after the passage of a predetermined time from completion of the application of said first radio frequency pulse sequence, and said inversion radio frequency pulse has a phase difference of 90° from each pulse of said first and second radio frequency sequences.
Claim 9
Dependent Claim
87 words
A nuclear magnetic resonance measuring method according to claim 1, wherein said first radio frequency sequence comprises odd-numbered radio frequency pulses, the phase of the first pulse of said second radio frequency pulse sequence is opposite to the phase of the first pulse of said first radio frequency pulse sequence, said second radio frequency sequence comprises even-numbered radio frequency pulses, and said inversion radio frequency pulse has the same phase as that of the pulses of either one of said first and second radio frequency pulse sequences.
Claim 10
Dependent Claim
82 words
A nuclear magnetic resonance measuring method according to claim 1, wherein said first radio frequency pulse sequence comprises odd-numbered radio frequency pulses, the first pulse of said second radio frequency pulse sequence has the same phase as the first pulse of said first radio frequency pulse sequence, said second radio frequency pulse sequence comprises even-numbered radio frequency pulses, and said inversion radio frequency pulse has a phase difference of 90° from each pulse of said first and second radio frequency pulse sequences.
Claim 11
Dependent Claim
80 words
A nuclear magnetic resonance measuring method according to claim 1, wherein said first radio frequency pulse sequence comprises even-numbered radio frequency pulses, the first pulse of said second radio frequency pulse sequence has an opposite phase to the first pulse of said first radio frequency pulse sequence, said second radio frequency pulse sequence comprises odd-numbered radio frequency pulses, and said inversion radio frequency pulse has the same phase as any of the pulses of said first radio frequency pulse sequence.
Claim 12
Dependent Claim
68 words
A nuclear magnetic resonance measuring method according to claim 1, wherein said second radio frequency pulse sequence comprises a greater number of pulses than said first radio frequency pulse sequence, and said inversion radio frequency pulse is applied immediately before the start of the application of said second radio frequency pulse sequence while keeping an interval from completion of the application of said first radio frequency pulse sequence.
Claim 13
Dependent Claim
51 words
A nuclear magentic resonance measuring method according to claim 1, wherein said second radio frequency pulse sequence comprises a smaller number of pulses than said first radio frequency pulse sequence, and said inversion radio frequency pulse is applied immediately after completion of the application of said first radio frequency pulse sequence.
References Cited (Backward Citations)
US4521732A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 7.5 Years (Year 8) | 2000-04-19 | 2000-10-19 | 2001-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-19 | 2004-10-19 | 2005-04-20 | $7700.00 | Window Closed / Lapsed |