US5200430A
Expired / Lapsed
US
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Debridement of bodily cavities using debridement fluids
Assignee: ESCALON IP HOLDINGS Inc
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Filing: 1991-03-21
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Granted: 1993-04-06
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Expires: 2011-03-21
Abstract
Abstract Foreign substances may be removed from a mammalian body cavity containing an aqueous phase by injecting into the cavity a water-immiscible, optically clear, biocompatible debridement fluid to at least partially displace the aqueous phase, and removing the aqueous phase and the foreign substances. In addition, a method is provided for visualizing a transparent foreign substance in a mammalian body cavity using a water-immiscible, optically clear, biocompatible fluid having a refractive index different from that of water. The debridement fluid may also be used to reposition desirable substances, such as a lens in an ocular cavity, or to remove a secondary membrane from a cavity lining or structure. Preferably, a liquid heavier than water, such as a perfluorocarbon liquid, is used as the debridement fluid.
Inventors
- 👤 Jay L. Federman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K49/00; A61K9/0048
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
82 words
A method for removing foreign substances from a mammalian body cavity containing an aqueous phase comprising injecting into the cavity at a location near the lower portion of the cavity a water-immiscible, optically clear, biocompatible debridement fluid having a specific gravity greater than water in an amount sufficient to at least partially displace the aqueous phase, removing the aqueous phase and the foreign substances from the cavity at a location near the upper portion of the cavity and removing the debridement fluid.
Claim 2
Independent Claim
82 words
A method for removing foreign substances from a mammalian body cavity containing an aqueous phase comprising injecting into the cavity at a location near the lower portion of the cavity a water-immiscible, optically clear, biocompatible debridement fluid having a specific gravity greater than water in an amount sufficient to at least partially displace the aqueous phase, removing the aqueous phase and the foreign substances from the cavity at a location near the upper portion of the cavity and removing the debridement fluid.
Claim 3
Dependent Claim
23 words
The method according to claim 1, wherein the debridement fluid is injected in an amount sufficient to displace all of the aqueous phase.
Claim 4
Dependent Claim
13 words
The method according to claim 1, wherein the debridement fluid comprises perfluorocarbon liquid.
Claim 5
Dependent Claim
31 words
The method according to claim 3, wherein the perfluorocarbon liquid is selected from the group consisting of perfluoropentane, perfluorodimethylcyclobutane, perfluoromethylcyclopentane, perfluorohexane, perfluoromethylcyclohexane, perfluoroheptane, perfluorooctane, perfluoro-1,3-dimethylcyclohexane, perfluorodecalin, perfluoro-1-methyldecalin, perfluorotributylamine, perfluorododecahydrofluorene and perfluorotetra-decahydrophenanthrene.
Claim 6
Dependent Claim
13 words
The method according to claim 4, wherein the perfluorocarbon comprises perfluorooctane or perfluorodecalin.
Claim 7
Dependent Claim
32 words
The method according to claim 1, wherein the bodily cavity is the abdominal cavity, thoracic cavity, fallopian tube, uterine cavity, intraocular cavity, intra-articular cavity, central nervous system ventricular cavity or dural spaces.
Claim 8
Dependent Claim
32 words
The method according to claim 1, wherein the foreign substances comprise foreign cells, inflammatory cells, blood cells, tumor cells, tissue debris, sera, protein, bacteria, virus, fungi, vitreous, silicone oil or foreign bodies.
Claim 9
Dependent Claim
20 words
The method according to claim 3, further comprising perfusing the liquid perfluorocarbon with oxygen prior to injection into the cavity.
Claim 10
Dependent Claim
25 words
The method according to claim 8, further comprising repeatedly perfusing the perfluorocarbon liquid after injection into the cavity to maintain a predetermined oxygen concentration level.
Claim 11
Independent Claim
103 words
A method for visualizing a transparent foreign substance or aqueous phase in a mammalian body cavity comprising injecting into the cavity a water-immiscible, optically clear, biocompatible fluid having a refractive index sufficiently different from the refractive index of the foreign substance or aqueous phase to cause visible refraction at the interface between the foreign substance or aqueous phase and the biocompatible fluid in an amount sufficient to at least partially surround the foreign substance, introducing visible light into the cavity and visualizing the foreign substance as an outline formed at the interface between the fluid and the transparent foreign substance or aqueous phase.
Claim 12
Independent Claim
103 words
A method for visualizing a transparent foreign substance or aqueous phase in a mammalian body cavity comprising injecting into the cavity a water-immiscible, optically clear, biocompatible fluid having a refractive index sufficiently different from the refractive index of the foreign substance or aqueous phase to cause visible refraction at the interface between the foreign substance or aqueous phase and the biocompatible fluid in an amount sufficient to at least partially surround the foreign substance, introducing visible light into the cavity and visualizing the foreign substance as an outline formed at the interface between the fluid and the transparent foreign substance or aqueous phase.
Claim 13
Dependent Claim
12 words
The method according to claim 10, wherein the fluid comprises perfluorocarbon liquid.
Claim 14
Dependent Claim
31 words
The method according to claim 11, wherein the perfluorocarbon liquid is selected from the group consisting of perfluoropentane, perfluorodimethylcyclobutane, perfluoromethylcyclopentane, perfluorohexane, perfluoromethylcyclohexane, perfluoroheptane, perfluorooctane, perfluoro-1,3-dimethylcyclohexane, perfluorodecalin, perfluoro-1-methyldecalin, perfluorotributylamine, perfluorododecahydrofluorene and perfluorotetradecahydrophenanthrene.
Claim 15
Dependent Claim
21 words
The method according to claim 10, wherein the biocompatible fluid has a refractive index at least 0.01more or less than water.
Claim 16
Dependent Claim
32 words
The method according to claim 10, wherein the body cavity is the abdominal cavity, thoracic cavity, fallopian tube, uterine cavity, intraocular cavity, intra-articular cavity, central nervous system ventricular cavity or dural spaces.
Claim 17
Independent Claim
61 words
A method for removing foreign substances from tissue within a mammalian body cavity where the foreign substances form a layer which overlies the tissue, comprising injecting into the cavity a water-immiscible, biocompatible fluid, having a specific gravity greater than water and the tissue, in an amount sufficient to cover the tissue, and mechanically pulling the foreign substances away from the tissue.
Claim 18
Independent Claim
61 words
A method for removing foreign substances from tissue within a mammalian body cavity where the foreign substances form a layer which overlies the tissue, comprising injecting into the cavity a water-immiscible, biocompatible fluid, having a specific gravity greater than water and the tissue, in an amount sufficient to cover the tissue, and mechanically pulling the foreign substances away from the tissue.
Claim 19
Dependent Claim
12 words
The method according to claim 15, wherein the fluid comprises perfluorocarbon liquid.
Claim 20
Dependent Claim
31 words
The method according to claim 16, wherein the perfluorocarbon liquid is selected from the group consisting of perfluoropentane, perfluorodimethylcyclobutane, perfluoromethylcyclopentane, perfluorohexane, perfluoromethylcyclohexane, perfluoroheptane, perfluorooctane, perfluoro-1,3-dimethylcyclohexane, perfluorodecalin, perfluoro-1-methyldecalin, perfluorotributylamine, perfluorododecahydrofluorene and perfluorotetra-decahydrophenanthrene.
Claim 21
Dependent Claim
12 words
The method according to claim 15, wherein the tissue comprises the retina.
Claim 22
Dependent Claim
14 words
The method according to claim 15, wherein the foreign substances comprise a secondary membrane.
References Cited (Backward Citations)
US4490351A
Cited
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