US4490351A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of treating disorders of an eye with liquid perfluorocarbons
Assignee: Vitrophage Inc
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Filing: 1982-03-15
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Granted: 1984-12-25
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Expires: 2002-03-15
Abstract
Abstract Liquid perfluorocarbons and substituted derivatives thereof are used as fluid substitutes for the vitreous or the aqueous of the eye. These liquids are also used to transparentize the cornea or lens when either becomes opacifed due to degeneration or cataract formation. Methods involving the use of these liquids during retinal surgery or diagnostic procedures of the eye are also disclosed.
Inventors
- 👤 Leland C. Clark, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/02; A61K31/025; A61L; A61L27/00; A61L2430/00; A61L2430/16
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
39 words
A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a liquid comprising a liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.
Claim 2
Independent Claim
39 words
A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a liquid comprising a liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein said liquid is introduced into the vitreous of the eye.
Claim 4
Dependent Claim
14 words
The method of claim 2 wherein said vitreous is substantially replaced with said liquid.
Claim 5
Dependent Claim
28 words
The method of claim 2 wherein the introduction of said liquid into said vitreous and the withdrawal of vitreous from said eye is conducted at the same time.
Claim 6
Dependent Claim
16 words
The method of claim 1 wherein said liquid is introduced into the aqueous of the eye.
Claim 7
Dependent Claim
14 words
The method of claim 5 wherein said aqueous is substantially replaced with said liquid.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein said liquid is introduced into the cornea.
Claim 9
Dependent Claim
23 words
The method of claim 7 wherein said liquid is introduced in a sufficient amount to form a substantially transparent window in said cornea.
Claim 10
Dependent Claim
13 words
The method of claim 1 wherein said liquid is introduced into the lens.
Claim 11
Dependent Claim
23 words
The method of claim 9 wherein said liquid is introduced in a sufficient amount to form a substantially transparent window in said lens.
Claim 12
Dependent Claim
30 words
The method of claim 1 wherein said perfluorocarbon or substituted derivative thereof is in a physical state selected from the group consisting of neat liquid, emulsion, gel, solution and suspension.
Claim 13
Dependent Claim
12 words
The method of claim 1 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.
Claim 14
Dependent Claim
29 words
The method of claim 12 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.
Claim 15
Dependent Claim
11 words
The method of claim 1 wherein said liquid perfluorocarbon is radiopaque.
Claim 16
Dependent Claim
22 words
The method of claim 14 wherein said perfluorocarbon is selected from the group consisting of a brominated perfluorocarbon and an iodinated perfluorocarbon.
Claim 17
Dependent Claim
11 words
The method of claim 14 wherein said liquid perfluorocarbon is perfluorooctylbromide.
Claim 18
Independent Claim
71 words
A method of repairing a retinal disorder of an eye of an animal comprising introducing into the vitreous of said eye a liquid comprising a liquid perfluorocarbon or substituted derivative thereof, locating said animal in a position to provide means for said liquid to maintain the retina against the choroid of said eye to repair said retina, and maintaining said animal in said position for a time to effect said repair.
Claim 19
Independent Claim
71 words
A method of repairing a retinal disorder of an eye of an animal comprising introducing into the vitreous of said eye a liquid comprising a liquid perfluorocarbon or substituted derivative thereof, locating said animal in a position to provide means for said liquid to maintain the retina against the choroid of said eye to repair said retina, and maintaining said animal in said position for a time to effect said repair.
Claim 20
Dependent Claim
16 words
The method of claim 17 wherein said retinal disorder is either a detached or torn retina.
Claim 21
Dependent Claim
16 words
The method of claim 17 wherein said liquid is removed from said vitreous after said repair.
Claim 22
Dependent Claim
28 words
The method of claim 1 comprising introducing a radiopaque liquid perfluorocarbon or substituted derivative thereof in an amount effective to detect radiopacity and x-raying said intraocular structural disorder.
Claim 23
Dependent Claim
23 words
The method of claim 20 wherein said liquid perfluorocarbon is selected from the group consisting of a brominated perfluorocarbon and an iodinated perfluorocarbon.
Claim 24
Dependent Claim
11 words
The method of claim 20 wherein said liquid perfluorocarbon is perfluorooctylbromide.
Claim 25
Independent Claim
38 words
A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a substantially transparent liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.
Claim 26
Independent Claim
38 words
A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a substantially transparent liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.
Claim 27
Dependent Claim
12 words
The method of claim 23 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.
Claim 28
Dependent Claim
29 words
The method of claim 24 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnapthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.
Claim 29
Independent Claim
55 words
A method of treating an intraocular structural disorder of an eye comprising introducing a liquid comprising a liquid perfluorocarbon or substituted derivative thereof into a structure of an eye under treatment selected from the group consisting of anterior chamber, a posterior chamber, cornea, lens and vitreous body in an amount effective to treat said disorder.
Claim 30
Independent Claim
55 words
A method of treating an intraocular structural disorder of an eye comprising introducing a liquid comprising a liquid perfluorocarbon or substituted derivative thereof into a structure of an eye under treatment selected from the group consisting of anterior chamber, a posterior chamber, cornea, lens and vitreous body in an amount effective to treat said disorder.
Claim 31
Independent Claim
38 words
A method of reparing a clouded cornea of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said cornea in an amount effective to provide a substantially transparent window therein.
Claim 32
Independent Claim
38 words
A method of reparing a clouded cornea of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said cornea in an amount effective to provide a substantially transparent window therein.
Claim 33
Dependent Claim
12 words
The method of claim 27 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.
Claim 34
Independent Claim
38 words
A method of reparing a clouded lens of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said lens in an amount effective to provide a substantially transparent window therein.
Claim 35
Independent Claim
38 words
A method of reparing a clouded lens of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said lens in an amount effective to provide a substantially transparent window therein.
Claim 36
Dependent Claim
12 words
The method of claim 29 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-25 | 1988-06-25 | 1988-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-25 | 1992-06-25 | 1992-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-25 | 1996-06-25 | 1996-12-25 | $7700.00 | Window Closed / Lapsed |