US5200398A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition for the preservation of organs comprising glucuronic acid or a physiologically tolerated salt or ester thereof
Assignee: Mount Sinai Hospital
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Filing: 1991-09-12
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Granted: 1993-04-06
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Expires: 2011-09-12
Abstract
Abstract A novel composition for the preservation of organs intended for transplantation and a method of preserving organs intended for transplantation using the composition are described. The composition contains glucuronic acid or a physiologically tolerated salt or ester thereof in a pharmaceutically acceptable organ preservation solution.
Inventors
- 👤 Steven M. Strasberg
- 👤 Robert P. C. Harvey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:21
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
34 words
A composition for the preservation and storage of organs intended for transplantation comprising an effective amount of glucuronic acid or a physiologically tolerated salt or ester thereof in a pharmaceutically acceptable organ preservation solution.
Claim 2
Dependent Claim
34 words
A composition for the preservation and storage of organs intended for transplantation comprising an effective amount of glucuronic acid or a physiologically tolerated salt or ester thereof in a pharmaceutically acceptable organ preservation solution.
Claim 3
Dependent Claim
21 words
The composition as claimed in claim 1, wherein the pharmaceutically acceptable organ preservation solution has substantially the composition of UW solution.
Claim 4
Dependent Claim
26 words
The composition as claimed in claim 1, wherein the pharmaceutically acceptable organ preservation solution is UW solution modified such that it is devoid of potassium lactobionate.
Claim 5
Dependent Claim
25 words
The composition as claimed in claim 3, wherein the concentration of glucuronic acid or the physiologically tolerated salt or ester thereof is about 100-140 mM.
Claim 6
Dependent Claim
82 words
A composition for the preservation and storage of organs intended for transplantation, comprising a pharmaceutically acceptable preservation solution comprising: (a) between about 3-200 mM of the sodium or potassium salt of glucuronate; (b) between about 5-40 mM KH 2 PO 4 ; (c) between about 1-50 mM MgSO 4 ; (d) between about 5-50 mM raffinose; (e) between about 1-50 mM adenosine; (f) between about 0.5-5 mM allopurinol; (g) between about 1-10 mM glutathione; and (h) between about 10-70 g/l hydroxyethyl starch.
Claim 7
Dependent Claim
82 words
A composition for the preservation and storage of organs intended for transplantation, comprising a pharmaceutically acceptable preservation solution comprising: (a) between about 3-200 mM of the sodium or potassium salt of glucuronate; (b) between about 5-40 mM KH 2 PO 4 ; (c) between about 1-50 mM MgSO 4 ; (d) between about 5-50 mM raffinose; (e) between about 1-50 mM adenosine; (f) between about 0.5-5 mM allopurinol; (g) between about 1-10 mM glutathione; and (h) between about 10-70 g/l hydroxyethyl starch.
Claim 8
Dependent Claim
21 words
The composition as claimed in claim 5, wherein the osmolality of the preservation solution is between about 270 and 330 mOsm/l.
Claim 9
Dependent Claim
21 words
The composition as claimed in claim 5, wherein the osmolality of the preservation solution is between about 320 and 330 mOsm/l.
Claim 10
Independent Claim
43 words
A method for preserving and storing an organ intended for transplantation in a patient comprising infusing said organ with a composition comprising an effective amount of glucuronic acid or a physiologically tolerated salt or ester thereof in a pharmaceutically acceptable organ preservation solution.
Claim 11
Independent Claim
43 words
A method for preserving and storing an organ intended for transplantation in a patient comprising infusing said organ with a composition comprising an effective amount of glucuronic acid or a physiologically tolerated salt or ester thereof in a pharmaceutically acceptable organ preservation solution.
Claim 12
Dependent Claim
21 words
The method as claimed in claim 8, wherein the pharmaceutically acceptable organ preservation solution has substantially the composition of UW solution.
Claim 13
Dependent Claim
26 words
The method as claimed in claim 8, wherein the pharmaceutically acceptable organ preservation solution is UW solution modified such that it is devoid of potassium lactobionate.
Claim 14
Dependent Claim
24 words
The method as claimed in claim 10, wherein the concentration of glucuronic acid or the physiological salt or ester thereof is about 100-140 mM.
Claim 15
Independent Claim
90 words
The method for preserving and storing organs intended for transplantation in a patient comprising infusing said organs with a composition comprising a pharmaceutically acceptable preservation solution comprising: (a) between about 3-200 mM of the sodium or potassium salt of glucuronate; (b) between about 5-40 mM of KH 2 PO 4 ; (c) between about 1-50 mM MgSo 4 ; (d) between about 5-50 mM raffinose; (e) between about 1-50 mM adenosine; (f) between about 0.5-5 mM allopurinol; (g) between about 1-10 mM glutathione; (h) between about 10-70 g/l hydroxyethyl starch.
Claim 16
Independent Claim
90 words
The method for preserving and storing organs intended for transplantation in a patient comprising infusing said organs with a composition comprising a pharmaceutically acceptable preservation solution comprising: (a) between about 3-200 mM of the sodium or potassium salt of glucuronate; (b) between about 5-40 mM of KH 2 PO 4 ; (c) between about 1-50 mM MgSo 4 ; (d) between about 5-50 mM raffinose; (e) between about 1-50 mM adenosine; (f) between about 0.5-5 mM allopurinol; (g) between about 1-10 mM glutathione; (h) between about 10-70 g/l hydroxyethyl starch.
Claim 17
Dependent Claim
21 words
The method as claimed in claim 12, wherein the osmolality of the preservation solution is between about 270 and 330 mOsm/l.
Claim 18
Dependent Claim
18 words
The method as claimed in claim 12 or 13, wherein the organ intended for transplantation is the liver.
Claim 19
Dependent Claim
21 words
The method as claimed in claim 12, wherein the osmolality of the preservation solution is between about 320 and 330 mOsm/l.
References Cited (Backward Citations)
US4959358A
Cited
US4798824A
Cited
US4873230A
Cited
US4879283A
Cited
US4870071A
Cited
US4898890A
Cited
US4920044A
Cited
US5082831A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-04-05 | 1996-10-05 | 1997-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-05 | 2000-10-05 | 2001-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-05 | 2004-10-05 | 2005-04-06 | $7700.00 | Window Closed / Lapsed |