US5188733A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus and process for effecting sequential peptide syntheses
Assignee: Boston University
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Filing: 1992-02-26
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Granted: 1993-02-23
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Expires: 2012-02-26
Abstract
Abstract A chemically modified membrane is positioned between a first template having a first set of holes and a second set of holes aligned with the first set of holes to define a plurality of exposed portions of the membrane in such as manner as to prevent collapse of pores in the membrane during application of a differential pressure across the membrane.
Inventors
- 👤 Zhengxin Wang
- 👤 Richard A. Laursen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:38
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5025; B01J; B01J19/00; B01J19/0046; C; C07; C07K; C07K1/00; C07K1/04; C07K1/045; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00306; B01J2219/00313; B01J2219/00315; B01J2219/00497; B01J2219/00527; B01J2219/00583; B01J2219/0059; B01J2219/00596; B01J2219/00603; B01J2219/00605; B01J2219/00612; B01J2219/00614; B01J2219/00617; B01J2219/00623; B01J2219/00626; B01J2219/00639; B01J2219/00641; B01J2219/00659; B01J2219/00718; B01J2219/0072; B01J2219/00725; C40; C40B; C40B40/00; C40B40/04; C40B40/10; C40B60/00; C40B60/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
127 words
Apparatus for effecting a plurality of independent chemical syntheses which comprises: a first template having a first set of through-holes positioned in a pattern, a second template having a second set of through-holes positioned in and aligned with said pattern, a chemically modified porous polymeric membrane positioned between said first and said second template, sealing means positioned between said first set of through-holes and second set of through-holes, means for applying differential pressure to effect fluid flow from said first set of holes to said second set of holes and means for preventing collapse of said membrane during application of said differential pressure, said chemically modified membrane having a first chemical moiety which permits covalent binding thereof with a second chemical moiety having a reactive carboxyl group.
Claim 2
Dependent Claim
127 words
Apparatus for effecting a plurality of independent chemical syntheses which comprises: a first template having a first set of through-holes positioned in a pattern, a second template having a second set of through-holes positioned in and aligned with said pattern, a chemically modified porous polymeric membrane positioned between said first and said second template, sealing means positioned between said first set of through-holes and second set of through-holes, means for applying differential pressure to effect fluid flow from said first set of holes to said second set of holes and means for preventing collapse of said membrane during application of said differential pressure, said chemically modified membrane having a first chemical moiety which permits covalent binding thereof with a second chemical moiety having a reactive carboxyl group.
Claim 3
Dependent Claim
22 words
The apparatus of claim 1 wherein said first set of through-holes and said second set of through-holes comprises a plurality of holes.
Claim 4
Dependent Claim
13 words
The apparatus of claim 1 wherein said chemical moiety includes a labile linker.
Claim 5
Dependent Claim
14 words
The apparatus of claim 2 wherein said chemical moiety includes an acid labile linker.
Claim 6
Dependent Claim
16 words
The apparatus of claim 1 which includes means for applying a differential pressure across said membrane.
Claim 7
Dependent Claim
16 words
The apparatus of claim 2 which includes means for applying a differential pressure across said membrane.
Claim 8
Dependent Claim
16 words
The apparatus of claim 3 which includes means for applying a differential pressure across said membrane.
Claim 9
Dependent Claim
16 words
The apparatus of claim 4 which includes means for applying a differential pressure across said membrane.
References Cited (Backward Citations)
US4797259A
Cited
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