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US5185142A Expired / Lapsed US ⏱️ 0.0 years remaining

Antigen-specific composition and in vivo methods for detecting and localizing an antigenic site and for radiotherapy

Assignee: United States Department of Health and Human Services
•
Filing: 1989-07-28
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Granted: 1993-02-09
•
Expires: 2009-07-28
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Abstract

Abstract A composition comprises an antigen-specific antibody or antigen-binding fragment thereof labeled with Iodine-124 at a site other than, and which does not significantly interfere with, the antibody-antigen binding site. An in vivo method of radiotherapy directed to an antigenic site comprises administering to a subject in need of the therapy an amount of the antigen-specific composition described above effective to attain a reduction of the size of a tumor associated with the antigen. An in vivo method for detecting and localizing an antigenic site in a subject in need of such detection comprises administering to the subject an amount of the antigen-specific composition of the invention effective to localize the antigen-antibody binding site and scanning the subject's body with a positron-emitter detector to attain the localization of the site. An in situ method of radiotherapy directed to an antigenic site in a subject in need of such therapy comprises detecting and localizing the site by the in vivo method described above and thereafter in situ delivering a positron-emitting labeled antibody chelate capable of binding to either the I-124 labeled antibody or fragment thereof, or to the antigen at a site other than the antibody-antigen binding site.

Inventors

  • 👤 Steven M. Larson
  • 👤 Ronald Finn
  • 👤 Jorge A. Carrasquillo
  • 👤 James C. Reynolds
  • 👤 Ronald D. Neumann
  • 👤 Martin C. Graham
  • 👤 Keith S. Pentlow

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 14:54
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1045; A61K51/1066; C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3053; A61K2121/00; A61K2123/00

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 161 words
An in situ method of radiotherapy directed to a tumor associated antigenic site in a subject in need of such therapy, comprising detecting and localizing said tumor-associated antigenic site by an in vivo method for detecting and localizing a tumor-associated antigenic site in a subject in need of such detection, comprising administering to the subject an amount of an antigen-specific composition comprising a tumor-associated antigen-specific antibody or tumor-associated antigen-binding fragment thereof labeled with Iodine-124 at a site other than, and which does not significantly interfere with, the antibody-antigen binding site effective to localize the antigen antibody binding site; scanning the subject body with an I-124 detector to attain the localization of the site; and thereafter in situ delivering a positron-emitting labeled antibody chelate to a subject, said chelate being capable of binding to either the I-124 tumor-associated antigen-binded labeled antibody or tumor-associated antigen-binding fragment thereof, or to the tumor associated antigen at an antigen site other than the antibody-antigen binding site.
Claim 2
Dependent Claim 161 words
An in situ method of radiotherapy directed to a tumor associated antigenic site in a subject in need of such therapy, comprising detecting and localizing said tumor-associated antigenic site by an in vivo method for detecting and localizing a tumor-associated antigenic site in a subject in need of such detection, comprising administering to the subject an amount of an antigen-specific composition comprising a tumor-associated antigen-specific antibody or tumor-associated antigen-binding fragment thereof labeled with Iodine-124 at a site other than, and which does not significantly interfere with, the antibody-antigen binding site effective to localize the antigen antibody binding site; scanning the subject body with an I-124 detector to attain the localization of the site; and thereafter in situ delivering a positron-emitting labeled antibody chelate to a subject, said chelate being capable of binding to either the I-124 tumor-associated antigen-binded labeled antibody or tumor-associated antigen-binding fragment thereof, or to the tumor associated antigen at an antigen site other than the antibody-antigen binding site.
Claim 3
Dependent Claim 12 words
The method of claim 1, wherein the composition is administered by injection.
Claim 4
Dependent Claim 13 words
The method of claim 2, wherein the composition is administered by intra-lymphatic injection.
Claim 5
Dependent Claim 18 words
The method of claim 1, wherein the antigen comprises a peritoneal tumor; and the composition is administered intraperitoneally.
Claim 6
Dependent Claim 38 words
A method according to claim 1, wherein said tumor-associated antigen-specific antibody or tumor-associated antigen-binding fragment comprises about 0.1 to 20 mCi of I 124 radiolabel/mg antibody or about 0.1 to 10 mCi of I 124 radiolabel/mg antigen-binding fragment.
Claim 7
Dependent Claim 26 words
The method of claim 1, wherein the composition is administered by injection; and the positron-emitting antibody chelate comprises about 0.1 to 20 mCi of radiolabel/mg antibody.
Claim 8
Dependent Claim 16 words
The method of claim 1, wherein the positron-emitting antibody chelate comprises an Iodine-124 labeled antibody chelate.

References Cited (Backward Citations)

US4444744A Cited
US4460561A Cited
US4454106A Cited
US4820505A Cited
US4876081A Cited
US4937183A Cited
US4917878A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1996-02-09 1996-08-10 1997-02-09 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2000-02-09 2000-08-10 2001-02-09 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2004-02-09 2004-08-10 2005-02-09 $7700.00 Window Closed / Lapsed

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