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US5182279A
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Benzothienopyrazinedione compounds and their preparation and use
Assignee: Novo Nordisk AS
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Filing: 1991-04-18
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Granted: 1993-01-26
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Expires: 2011-04-18
Abstract
Abstract Novel [1]benzothieno[2,3-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof of the general formula (I) <IMAGE> (I) wherein R1, R2, R3 and R4 independently represent hydrogen, halogen, alkyl, alkoxy or trifluoromethyl. The compounds are useful for treating a central nervous system ailment associated with the NMDA receptor-associated glycine site.
Inventors
- 👤 Anker S. Jorgensen
- 👤 Carsten E. Stidsen
- 👤 Peter Faarup
- 👤 Frederik C. Gronvald
- 👤 Flemming E. Nielsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:41
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04; A; A61; A61P; A61P25/00; A61P25/08; A61P25/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
36 words
A compound of formula (I) ##STR14## wherein R 1 , R 2 , R 3 and R 4 independently are hydrogen, halogen, C 1-6 -alkyl, C 1-6 -alkoxy or trifluoromethyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
36 words
A compound of formula (I) ##STR14## wherein R 1 , R 2 , R 3 and R 4 independently are hydrogen, halogen, C 1-6 -alkyl, C 1-6 -alkoxy or trifluoromethyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
21 words
A compound which is 8-fluoro[1]benzothieno [2,3-b]pyrazine-2,3(1H, 4H)=dione; 8-chloro[1]benzothieno[2,3-b]pyrazine-2,3(1H, 4H)-dione; 8-bromo[1]benzothieno[2,3-b]pyrzine-2,3(1H, 4H)-dione; 6-chloro[1]benzothieno[2,3-b]pyrazine-2,3(1H, 4H)-dione; 6fluoro[1]benzothieno[2,3-b]pyrzzine-2,3(1H, 4H)-dione; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
21 words
A compound which is 8-fluoro[1]benzothieno [2,3-b]pyrazine-2,3(1H, 4H)=dione; 8-chloro[1]benzothieno[2,3-b]pyrazine-2,3(1H, 4H)-dione; 8-bromo[1]benzothieno[2,3-b]pyrzine-2,3(1H, 4H)-dione; 6-chloro[1]benzothieno[2,3-b]pyrazine-2,3(1H, 4H)-dione; 6fluoro[1]benzothieno[2,3-b]pyrzzine-2,3(1H, 4H)-dione; or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
31 words
A pharmaceutical composition fo ruse in treating epilepsy, convulsions, anxiety or ischemia comprising an effective amount of a compound according to claim 1 together with a pharmaceutically acceptable carrier or diluent.
Claim 6
Dependent Claim
22 words
The pharmaceutical composition according to claim 3 in the form of an oral dosage unit contianing about 1-200 mg of the compound.
Claim 7
Dependent Claim
26 words
A method of treating epilepsy, convulsions, anxiety or ischemia in a subject in need thereof comprising administering an effective of a compound according to claim 1.
Claim 8
Dependent Claim
24 words
A method of treating epilepsy, convulsions, anxiety or ischemia in a subject in need thereof comprising administering a pharmaceutical composition according to claim 3.
References Cited (Backward Citations)
EP0398283A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-01-26 | 1996-07-27 | 1997-01-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-01-26 | 2000-07-27 | 2001-01-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-01-26 | 2004-07-27 | 2005-01-26 | $7700.00 | Window Closed / Lapsed |