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US5177102A
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US
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Polyisoprene compounds and salts thereof
Assignee: Sanwa Kagaku Kenkyusho Co Ltd
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Filing: 1991-05-03
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Granted: 1993-01-05
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Expires: 2011-05-03
Abstract
Abstract There are given disclosures on a polyisoprene compound of the formula ##STR1## wherein Y is S, O, NH or ##STR2## l is an integer of 2-10, Z is a group of ##STR3## R 1 and R 2 are same or different and each means a hydrogen atom or an alkyl group having C 1-4 , m is an integer of 0 or 1, and n is an integer of 0, 1 or 2, a salt thereof, a process for the preparation of same, and use thereof.
Inventors
- 👤 Masayasu Kurono
- 👤 Yasuaki Kondo
- 👤 Takuji Yamaguchi
- 👤 Ryoichi Unno
- 👤 Hiromoto Kimura
- 👤 Noboru Kuboyama
- 👤 Takashi Ito
- 👤 Mitsuru Oka
- 👤 Akira Tashita
- 👤 Kazumasa Nakano
- 👤 Kiichi Sawai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:00
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; A; A61; A61P; A61P1/00; A61P1/04; C07C; C07C323/00; C07C323/23; C07C323/24; C07C323/25
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
60 words
A polyisoprene compound of the formula ##STR24## wherein Y is a hydrogen atom or a group of ##STR25## a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having, C 1-4 and m is an integer of 1 or 2, and a salt thereof.
Claim 2
Dependent Claim
60 words
A polyisoprene compound of the formula ##STR24## wherein Y is a hydrogen atom or a group of ##STR25## a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having, C 1-4 and m is an integer of 1 or 2, and a salt thereof.
Claim 3
Dependent Claim
29 words
A polyisoprene compound and a salt thereof as claimed in claim 1, wherein said compound is selected from the group consisting of a) 5-{[(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane; b) 5-{[(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane; and c) 5-{[bis(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane.
Claim 4
Dependent Claim
50 words
A polyisoprene compound of the formula ##STR26## wherein a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 and m is an integer of 0 or 1, and a salt thereof.
Claim 5
Dependent Claim
50 words
A polyisoprene compound of the formula ##STR26## wherein a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 and m is an integer of 0 or 1, and a salt thereof.
Claim 6
Dependent Claim
27 words
A polyisoprene compound and a salt thereof as claimed in claim 3, wherein said compound is selected from the group consisting of a) N-[2-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ylthio)ethyl]-(1-azabicyclo[3.3.0]octan-5-yl)acetamide; and b) N-[2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetraconta-decaen-1-ylthio)ethyl]-(1-azabicyclo[3.3.0]octan-5-yl)acetamide.
Claim 7
Dependent Claim
84 words
A pharmaceutical composition for curing a digestive ulcer, which comprises an effective amount of a polyisoprene compound of the formula ##STR27## wherein Y is a hydrogen atom or a group of ##STR28## a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 , and m is an integer of 1 or 2, or a salt thereof, in association with a pharmaceutically acceptable carrier or excipient.
Claim 8
Dependent Claim
84 words
A pharmaceutical composition for curing a digestive ulcer, which comprises an effective amount of a polyisoprene compound of the formula ##STR27## wherein Y is a hydrogen atom or a group of ##STR28## a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 , and m is an integer of 1 or 2, or a salt thereof, in association with a pharmaceutically acceptable carrier or excipient.
Claim 9
Dependent Claim
25 words
A pharmaceutical composition as claimed in claim 5, wherein said compound is selected from the group consisting of a) 5-{[(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane; b) 5-{[(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane; and c) 5-{[bis(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl)amino]methyl}-1-azabicyclo[3.3.0]octane.
Claim 10
Dependent Claim
74 words
A pharmaceutical composition for curing a digestive ulcer, which comprises an effective amount of a polyisoprene compound of the formula ##STR29## wherein a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 , and m is an integer of 0 or 1, or a salt thereof, in association with a pharmaceutically acceptable carrier or excipient.
Claim 11
Dependent Claim
74 words
A pharmaceutical composition for curing a digestive ulcer, which comprises an effective amount of a polyisoprene compound of the formula ##STR29## wherein a is an integer of 2-10, R 1 and R 2 are the same or different and each means a hydrogen atom or an alkyl group having C 1-4 , and m is an integer of 0 or 1, or a salt thereof, in association with a pharmaceutically acceptable carrier or excipient.
Claim 12
Dependent Claim
23 words
A pharmaceutical composition as claimed in claim 7, wherein said compound is selected from the group consisting of a) N-[2-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ylthio)ethyl]-(1-azabicyclo[3.3.0]octan-5-yl)acetamide; and b) N-[2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetraconta-decaen-1-ylthio)ethyl]-(1-azabicyclo[3.3.0]octan-5-yl)acetamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-01-05 | 1996-07-06 | 1997-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-01-05 | 2000-07-06 | 2001-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-01-05 | 2004-07-06 | 2005-01-05 | $7700.00 | Window Closed / Lapsed |