US5175383A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Animal model for benign prostatic disease
Assignee: Harvard University
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Filing: 1989-02-17
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Granted: 1992-12-29
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Expires: 2009-02-17
Abstract
Abstract A male transgenic mouse containing germ cells and somatic cells which contain a recombinant gene which is a vertebrate gene in the int-2/FGF family which is capable of promoting benign prostatic hyperplasia or hypertrophy in said transgenic mouse, said gene being introduced into the mouse, or an ancestor of the mouse, at an embryonic stage.
Inventors
- 👤 Philip Leder
- 👤 William J. Muller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:04
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/8509; A; A01; A01K; A01K67/00; A01K67/027; A01K67/0275; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/50; A01K2217/00; A01K2217/05; A01K2217/20; A01K2227/00; A01K2227/10; A01K2227/105; A01K2267/00; A01K2267/03; A01K2267/0331
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
66 words
A male transgenic mouse, whose germ cells and somatic cells contain an int-2 gene which is operably linked to a promoter effective for the expression of said gene in the urogenital tissues of said mouse and effective for the promotion of benign prostatic hyperplasia or hypertrophy in said mouse, said gene being introduced into said mouse, or an ancestor of said mouse, at an embryonic stage.
Claim 2
Dependent Claim
66 words
A male transgenic mouse, whose germ cells and somatic cells contain an int-2 gene which is operably linked to a promoter effective for the expression of said gene in the urogenital tissues of said mouse and effective for the promotion of benign prostatic hyperplasia or hypertrophy in said mouse, said gene being introduced into said mouse, or an ancestor of said mouse, at an embryonic stage.
Claim 3
Dependent Claim
27 words
The mouse of claim 1, wherein a chromosome of said mouse includes an endogenous coding sequence substantially the same as the coding sequence of said int-2 gene.
Claim 4
Dependent Claim
29 words
The mouse of claim 2, wherein said int-2 gene has integrated into a chromosome of said mouse at a site different from the location of said endogenous coding sequence.
Claim 5
Dependent Claim
32 words
The mouse of claim 2, wherein transcription of said int-2 gene is under the control of a promoter sequence different from the promoter sequence controlling the transcription of said endogenous coding sequence.
Claim 6
Dependent Claim
17 words
The mouse of claim 4, wherein said promoter sequence controlling transcription of said int-2 gene is inducible.
Claim 7
Dependent Claim
20 words
The mouse of claim 1, wherein transcription of said int-2 gene is under the control of a viral promoter sequence.
Claim 8
Dependent Claim
17 words
The mouse of claim 6, wherein said viral promoter sequence comprises the sequence of the MMTV promoter.
References Cited (Backward Citations)
US4736866A
Cited
US4736866B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-29 | 1996-06-29 | 1996-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-29 | 2000-06-29 | 2000-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-29 | 2004-06-29 | 2004-12-29 | $7700.00 | Window Closed / Lapsed |