US4736866A
Expired / Lapsed
US
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Transgenic non-human mammals
Assignee: Harvard University
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Filing: 1984-06-22
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Granted: 1988-04-12
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Expires: 2004-06-22
Abstract
Abstract A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
Inventors
- 👤 Philip Leder
- 👤 Timothy A. Stewart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:21
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/8509; A; A01; A01K; A01K67/00; A01K67/027; A01K67/0275; C07; C07K; C07K14/00; C07K14/005; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5008; G01N33/5014; G01N33/5017; G01N33/53; G01N33/575; G01N33/57575; A01K2217/00; A01K2217/05; A01K2217/20; A01K2227/00; A01K2227/10; A01K2227/105; A01K2267/00; A01K2267/03; A01K2267/0331; A01K2267/0393; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/11011; C12N2740/11022
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
32 words
A transgenic non-human mammal all of whose germ cells and somatic cells contain a recombinant activated oncogene sequence introduced into said mammal, or an ancestor of said mammal, at an embryonic stage.
Claim 2
Dependent Claim
32 words
A transgenic non-human mammal all of whose germ cells and somatic cells contain a recombinant activated oncogene sequence introduced into said mammal, or an ancestor of said mammal, at an embryonic stage.
Claim 3
Dependent Claim
26 words
The mammal of claim 1, a chromosome of said mammal including an endogenous coding sequence substantially the same as a coding sequence of said oncogene sequence.
Claim 4
Dependent Claim
28 words
The mammal of claim 2, said oncogene sequence being integrated into a chromosome of said mammal at a site different from the location of said endogenous coding sequence.
Claim 5
Dependent Claim
32 words
The mammal of claim 2 wherein transcription of said oncogene sequence is under the control of a promoter sequence different from the promoter sequence controlling the transcription of said endogenous coding sequence.
Claim 6
Dependent Claim
17 words
The mammal of claim 4 wherein said promoter sequence controlling transcription of said oncogene sequence is inducible.
Claim 7
Dependent Claim
17 words
The mammal of claim 1 wherein said oncogene sequence comprises a coding sequence of a c-myc gene.
Claim 8
Dependent Claim
20 words
The mammal of claim 1 wherein transcription of said oncogene sequence is under the control of a viral promoter sequence.
Claim 9
Dependent Claim
17 words
The mammal of claim 7 wherein said viral promoter sequence comprises a sequence of an MMTV promoter.
Claim 10
Dependent Claim
17 words
The mammal of claim 7 wherein said viral promoter sequence comprises a sequence of an RSV promoter.
Claim 11
Dependent Claim
20 words
The mammal of claim 1 wherein transcription of said oncogene sequence is under the control of a synthetic promoter sequence.
Claim 12
Dependent Claim
10 words
The mammal of claim 1, said mammal being a rodent.
Claim 13
Dependent Claim
10 words
The mammal of claim 11, said rodent being a mouse.
References Cited (Backward Citations)
US4579821A
Cited
US4535058A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-12 | 1991-10-12 | 1992-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-12 | 1995-10-12 | 1996-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-12 | 1999-10-12 | 2000-04-12 | $7700.00 | Window Closed / Lapsed |