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US5169645A
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Directly compressible granules having improved flow properties
Assignee: Duquesne University of the Holy Spirit
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Filing: 1989-10-31
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Granted: 1992-12-08
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Expires: 2009-10-31
Abstract
Abstract Directly compressible, wax-containing granules having improved flow properties are obtained when waxes are admixed in the melt with certain flow improving additives, followed by cooling and granulation of the admixture. In certain embodiments of the invention, only the wax itself melts in the melt combination of the wax(es) and additives(s), and in other cases both the wax(es) and the additives(s) will both melt. In either case, the melt combination of the wax(es) with the additive(s) yields, upon cooling and granulation, a wax-containing particulate drug diluent having improved and unexpected flow properties.
Inventors
- 👤 Atul J. Shukla
- 👤 Anumontri Vattanasiri
- 👤 Jyothi S. Nambiar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/1617; A61K9/1641
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
156 words
A modified-wax, directly compressible diluent consisting of: 1) at least one wax selected from the group consisting of carnauba wax, beeswax, glyceride esters, fatty acid esters, hydrogenated vegetable oils, hydrogenated animal fats, stearyl alcohols, stearyl alcohol derivatives, polyethylene glycols, and polyethylene glycol derivatives, and 2) at least one wax-modifying composition selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetate, ethylene vinyl acetate polymer, acrylic polymer, acrylic copolymer cellulose compositions, cellulose derivatives, polyethylene oxide, poly(methylvinylether/maleic acid), carbomers, vinyl chloride vinyl acetate polymers, finely divided silica, particulate sodium chloride, particulate sodium bromide, particulate calcium chloride, particulate calcium bromide, particulate sugar, particulate calcium phosphate, particulate calcium carbonate, particulate oyster shells and ground bone meal, wherein said wax and said wax-modifying composition are present in the ratio of 1:4-4:1 and further wherein said wax and said wax-modifying composition are combined in adherence patterns characteristic of the melt combination of said wax and said wax-modifying composition.
Claim 2
Dependent Claim
156 words
A modified-wax, directly compressible diluent consisting of: 1) at least one wax selected from the group consisting of carnauba wax, beeswax, glyceride esters, fatty acid esters, hydrogenated vegetable oils, hydrogenated animal fats, stearyl alcohols, stearyl alcohol derivatives, polyethylene glycols, and polyethylene glycol derivatives, and 2) at least one wax-modifying composition selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetate, ethylene vinyl acetate polymer, acrylic polymer, acrylic copolymer cellulose compositions, cellulose derivatives, polyethylene oxide, poly(methylvinylether/maleic acid), carbomers, vinyl chloride vinyl acetate polymers, finely divided silica, particulate sodium chloride, particulate sodium bromide, particulate calcium chloride, particulate calcium bromide, particulate sugar, particulate calcium phosphate, particulate calcium carbonate, particulate oyster shells and ground bone meal, wherein said wax and said wax-modifying composition are present in the ratio of 1:4-4:1 and further wherein said wax and said wax-modifying composition are combined in adherence patterns characteristic of the melt combination of said wax and said wax-modifying composition.
Claim 3
Dependent Claim
156 words
A modified-wax, directly compressible diluent consisting of: 1) at least one wax selected from the group consisting of carnauba wax, beeswax, glyceride esters, fatty acid esters, hydrogenated vegetable oils, hydrogenated animal fats, stearyl alcohols, stearyl alcohol derivatives, polyethylene glycols, and polyethylene glycol derivatives, and 2) at least one wax-modifying composition selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetate, ethylene vinyl acetate polymer, acrylic polymer, acrylic copolymer, cellulose compositions, cellulose derivatives, polyethylene oxide, poly(methylvinylether/maleic acid), carbomers, vinyl chloride vinyl acetate polymers, finely divided silica, particulate sodium chloride, particulate sodium bromide, particulate calcium chloride, particulate calcium bromide, particulate sugar, particulate calcium phosphate, particulate calcium carbonate, particulate oyster shells and ground bone meal, wherein said wax and said wax-modifying composition are present in the ratio of 1:9-9:1 and further wherein said wax and said wax-modifying composition are combined in adherence patterns characteristic of the melt combination of said wax and said wax-modifying composition.
Claim 4
Dependent Claim
156 words
A modified-wax, directly compressible diluent consisting of: 1) at least one wax selected from the group consisting of carnauba wax, beeswax, glyceride esters, fatty acid esters, hydrogenated vegetable oils, hydrogenated animal fats, stearyl alcohols, stearyl alcohol derivatives, polyethylene glycols, and polyethylene glycol derivatives, and 2) at least one wax-modifying composition selected from the group consisting of polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetate, ethylene vinyl acetate polymer, acrylic polymer, acrylic copolymer, cellulose compositions, cellulose derivatives, polyethylene oxide, poly(methylvinylether/maleic acid), carbomers, vinyl chloride vinyl acetate polymers, finely divided silica, particulate sodium chloride, particulate sodium bromide, particulate calcium chloride, particulate calcium bromide, particulate sugar, particulate calcium phosphate, particulate calcium carbonate, particulate oyster shells and ground bone meal, wherein said wax and said wax-modifying composition are present in the ratio of 1:9-9:1 and further wherein said wax and said wax-modifying composition are combined in adherence patterns characteristic of the melt combination of said wax and said wax-modifying composition.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-12-08 | 1996-06-08 | 1996-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-08 | 2000-06-08 | 2000-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-08 | 2004-06-08 | 2004-12-08 | $7700.00 | Window Closed / Lapsed |