US5164379A
Expired / Lapsed
US
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Sucralfate/cyclodextrin complexes
Assignee: Bristol Myers Co
•
Filing: 1991-07-15
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Granted: 1992-11-17
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Expires: 2011-07-15
Abstract
Abstract Complexes of sucralfate with alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin or 2-hydroxypropyl beta cyclodextrin are disclosed. Also disclosed are a process for producing complexes and compositions and a method for reducing gastric injury, employing the complexes.
Inventors
- 👤 Randy J. Koslo
- 👤 Vincent J. Farina
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
22 words
A sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 2
Dependent Claim
22 words
A sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 3
Dependent Claim
15 words
The complex as claimed in claim 1, wherein the complex is the sucralfate/alpha cyclodextrin complex.
Claim 4
Dependent Claim
15 words
The complex as claimed in claim 1, wherein the complex is the sucralfate/beta cyclodextrin complex.
Claim 5
Dependent Claim
15 words
The complex as claimed in claim 1, wherein the complex is the sucralfate/gamma cyclodextrin complex.
Claim 6
Dependent Claim
16 words
The complex as claimed in claim 1, wherein the complex is the sucralfate/2-hydroxypropyl beta cyclodextrin complex.
Claim 7
Independent Claim
52 words
A method for reducing injury to gastric mucosa of a mammal when the mucosa is contacted with an irritant comprising administering to such mammal a mucosal injury reducing amount of a sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 8
Independent Claim
52 words
A method for reducing injury to gastric mucosa of a mammal when the mucosa is contacted with an irritant comprising administering to such mammal a mucosal injury reducing amount of a sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 9
Dependent Claim
15 words
The method as claim in claim 6, wherein the complex is co-administered with the irritant.
Claim 10
Dependent Claim
21 words
The method as claimed in claim 6, wherein the complex is administered prior to contact of the mucosa by the irritant.
Claim 11
Dependent Claim
15 words
The method as claimed in claim 6, wherein the irritant is a nonsteroidal antiinflammatory agent.
Claim 12
Dependent Claim
32 words
The method as claimed in claim 9, wherein the nonsteroidal antiinflammatory agent is selected from the group consisting of aspirin, ibuprofen, naproxen, indomethacin, meclofenamate, piroxicam, phenylbutazone, choline salicylate and choline magnesium trisalicylate.
Claim 13
Dependent Claim
12 words
The method as claimed in claim 10, wherein the irritant is aspirin.
Claim 14
Dependent Claim
12 words
The method as claimed in claim 6, wherein the irritant is ethanol.
Claim 15
Dependent Claim
53 words
A composition having reduced propensity for causing injury to mammalian gastric mucosa comprising a normally gastric mucosal injury causing amount of a gastric irritant and a gastric mucosal protective amount of a sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 16
Dependent Claim
53 words
A composition having reduced propensity for causing injury to mammalian gastric mucosa comprising a normally gastric mucosal injury causing amount of a gastric irritant and a gastric mucosal protective amount of a sucralfate/cyclodextrin complex selected from the group consisting of sucralfate/alpha cyclodextrin, sucralfate/beta cyclodextrin, sucralfate/gamma cyclodextrin, sucralfate/ 2-hydroxypropyl beta cyclodextrin and mixtures thereof.
Claim 17
Dependent Claim
16 words
The composition as claimed in claim 13, wherein the gastric irritant is a nonsteroidal antiinflammatory agent.
Claim 18
Dependent Claim
32 words
The composition as claimed in claim 14, wherein the nonsteroidal antiinflammatory agent is selected from the group consisting of aspirin, ibuprofen, naproxen, indomethacin, meclofenamate, piroxicam, phenylbutazone, choline salicylate and choline magnesium trisalicylate.
Claim 19
Dependent Claim
12 words
The composition as claimed in claim 15, wherein the irritant is aspirin.
Claim 20
Dependent Claim
81 words
A process for producing a sucralfate/cyclodextrin complex as claimed in claim 1, comprising freezing, at a temperature of about -50° C. to about -70° C., an aqueous mixture of sucralfate and a cyclodextrin selected from the group consisting of alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin and 2-hydroxypropyl beta cyclodextrin, the sucralfate and the cyclodextrin being present in an about equimolar ratio, the freezing being continued until the mixture is solidified, then freeze drying the solidified mixture, whereby said complex is produced.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-11-17 | 1996-05-18 | 1996-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-17 | 2000-05-18 | 2000-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-17 | 2004-05-18 | 2004-11-17 | $7700.00 | Window Closed / Lapsed |