Patent US476257A successfully refreshed from Google Patents.
Patent US5164014A successfully refreshed from Google Patents.
US5164014A
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US
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Process for the manufacture of a directly compressible starch for use in the manufacture of tablets, and tablets obtained
Assignee: Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
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Filing: 1990-05-15
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Granted: 1992-11-17
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Expires: 2010-05-15
Abstract
Abstract The present invention relates to a process for the preparation of grains of starch, which comprises granulating a mixture obtained by spraying 1 to 20%, and preferably 2 to 6% by weight, of a starch paste obtained from native starch under mild conditions, on to 99 to 80% by weight of grains of native starch, and drying, grinding and sieving the resulting product to give aggregates (grains) having a mean particle size of between 100 and about 500 μm.
Inventors
- 👤 Bernard Brancq
- 👤 Gerard Trouve
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:29
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/12; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2059; C08B; C08B30/00; C08B30/06; C08J2303/00; C08J2303/02
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
118 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 2
Dependent Claim
118 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 3
Dependent Claim
23 words
The process according to claim 1, wherein the concentration of starch in the paste is between about 2 and about 10% by weight.
Claim 4
Dependent Claim
23 words
The process according to claim 1, wherein the concentration of starch in the paste is between about 5 and about 8% by weight.
Claim 5
Dependent Claim
31 words
The process according to claim 1, wherein the starch paste has a viscosity of less than about 1500 mPa.s at about 85° C. for a solution containing about 5% by weight.
Claim 6
Dependent Claim
23 words
The process according to claim 1, wherein the starch paste used is obtained from the same native starch with which it is granulated.
Claim 7
Dependent Claim
23 words
The process according to claim 1, wherein in the granulation step b), the starch paste is sprayed onto the grains of native starch.
Claim 8
Dependent Claim
23 words
The process according to claim 1, wherein in the granulation step b), the starch paste is poured onto the grains of native starch.
Claim 9
Dependent Claim
118 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 10
Dependent Claim
118 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 11
Dependent Claim
127 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a) and used at a temperature above about 60° C.; and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 12
Dependent Claim
127 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a) and used at a temperature above about 60° C.; and c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 13
Dependent Claim
23 words
The process according to claim 9, wherein the concentration of starch in the paste is between about 2 and about 10% by weight.
Claim 14
Dependent Claim
23 words
The process according to claim 9, wherein the starch paste used is obtained from the same native starch with which it is granulated.
Claim 15
Dependent Claim
23 words
The process according to claim 9, wherein in the granulation step b), the starch paste is sprayed onto the grains of native starch.
Claim 16
Dependent Claim
23 words
The process according to claim 9, wherein in the granulation step b), the starch paste is poured onto the grains of native starch.
Claim 17
Dependent Claim
69 words
Novel starch granules suitable for compression into tablets, comprising starch granules prepared by the mutual adhesion of grains of native starch by means of starch paste, which have a mean particle size of between about 100 and about 500 μm, which give, on compression under about 20 daN, tablets having a crushing strength of at least about 50N, and which disintegrate in water in less than about 5 minutes.
Claim 18
Dependent Claim
69 words
Novel starch granules suitable for compression into tablets, comprising starch granules prepared by the mutual adhesion of grains of native starch by means of starch paste, which have a mean particle size of between about 100 and about 500 μm, which give, on compression under about 20 daN, tablets having a crushing strength of at least about 50N, and which disintegrate in water in less than about 5 minutes.
Claim 19
Dependent Claim
19 words
The novel starch granules of claim 14, wherein the mutual adhesion of grains of native starch is point adhesion.
Claim 20
Dependent Claim
13 words
Tablets which contain the novel starch granules of claim 15 as the excipient.
Claim 21
Dependent Claim
112 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a residual moisture of 11-12% and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 22
Dependent Claim
112 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a residual moisture of 11-12% and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 23
Dependent Claim
112 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a residual moisture of 11-12% and, grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
Claim 24
Dependent Claim
112 words
A process for the preparation of granules of directly compressible starch which comprises: a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85° C. and a heating time of about 15 to about 45 minutes; b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a); and c) drying the wet mass thus obtained to a residual moisture of 11-12% and, grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 μm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-11-17 | 1996-05-18 | 1996-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-17 | 2000-05-18 | 2000-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-17 | 2004-05-18 | 2004-11-17 | $7700.00 | Window Closed / Lapsed |