Patent US5157049A successfully refreshed from Google Patents.
US5157049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
Assignee: United States Department of Health and Human Services
•
Filing: 1991-10-31
•
Granted: 1992-10-20
•
Expires: 2011-10-31
Abstract
Abstract The invention involves the treatment of cancer in humans by administering water soluble derivatives of taxol. The types of cancer so treatable are those sensitive to treatment with taxol.
Inventors
- 👤 Rudiger D. Haugwitz
- 👤 Leon Zalkow
- 👤 Jan Glinski
- 👤 Mathew Suffness
- 👤 Howard M. Deutsch
- 👤 Venkatachala Narayanan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/335; A61K31/40; A61K31/435; A61K31/44; A61K31/445; A61K31/535; A61K31/54; C; C07; C07D; C07D305/00; C07D305/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
211 words
A method of treating cancer sensitive to treatment with the compound set forth below, comprising administering to a subject afflicted with said cancer, an effective amount of the water soluble derivative of the compound of the following formula to cause regression of said cancer: ##STR4## Wherein: Z=ethylene, propylene, CHCH, 1,2-cyclohexane, 1,2-phenylene, R 1 =OH base, NR 2 R 3 , OR 3 , SR 3 , OCH 2 CONR 4 R 5 , OH R 2 =hydrogen, methyl R 3 =(CH 2 ) n NR 6 R 7 ; (CH 2 ) n NR.sup.⊕6 R 7 R 8 X.sup.⊖ n=1 to 3 R 4 =hydrogen, lower alkyl containing 1 to 4 carbons R 5 =hydrogen, lower alkyl containing 1 to 4 carbons, benzyl, hydroxyethyl, CH 2 CO 2 H, dimethylaminoethyl R 6 R 7 =lower alkyl containing 1 or 2 carbons, benzyl or R 6 and R 7 together with the nitrogen atom of NR 6 R 7 form the following rings ##STR5## R 8 =lower alkyl containing 1 or 2 carbons, benzyl X.sup.⊖ =halide base=NH 3 , (HOC 2 H 4 ) 3 N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 OH) 2 , NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH, KOH.
Claim 2
Independent Claim
211 words
A method of treating cancer sensitive to treatment with the compound set forth below, comprising administering to a subject afflicted with said cancer, an effective amount of the water soluble derivative of the compound of the following formula to cause regression of said cancer: ##STR4## Wherein: Z=ethylene, propylene, CHCH, 1,2-cyclohexane, 1,2-phenylene, R 1 =OH base, NR 2 R 3 , OR 3 , SR 3 , OCH 2 CONR 4 R 5 , OH R 2 =hydrogen, methyl R 3 =(CH 2 ) n NR 6 R 7 ; (CH 2 ) n NR.sup.⊕6 R 7 R 8 X.sup.⊖ n=1 to 3 R 4 =hydrogen, lower alkyl containing 1 to 4 carbons R 5 =hydrogen, lower alkyl containing 1 to 4 carbons, benzyl, hydroxyethyl, CH 2 CO 2 H, dimethylaminoethyl R 6 R 7 =lower alkyl containing 1 or 2 carbons, benzyl or R 6 and R 7 together with the nitrogen atom of NR 6 R 7 form the following rings ##STR5## R 8 =lower alkyl containing 1 or 2 carbons, benzyl X.sup.⊖ =halide base=NH 3 , (HOC 2 H 4 ) 3 N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 OH) 2 , NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH, KOH.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said water soluble derivative is 2'-succinyl-taxol.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein said water soluble derivative is 2'-succinyl taxol triethanolamine.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said water soluble derivative is 2'-glutaryl-taxol.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein said water soluble derivative is 2'-glutaryl-taxol triethanolamine salt.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein said water soluble derivative is 2'-O-ester with N-(dimethylaminoethyl) glutamide.
Claim 8
Dependent Claim
17 words
The method of claim 1 wherein said water soluble derivative is 2'-O-ester with N-(dimethylaminoethyl) glutamide hydrochloride salt.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-20 | 1996-04-20 | 1996-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-20 | 2000-04-20 | 2000-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-20 | 2004-04-20 | 2004-10-20 | $7700.00 | Window Closed / Lapsed |