US5154913A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radioiodinated benzamines method of their use as radioimaging agents
Assignee: Vanderbilt University
•
Filing: 1991-05-28
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Granted: 1992-10-13
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Expires: 2011-05-28
Abstract
Abstract Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.
Inventors
- 👤 Tomas De Paulis
- 👤 Robert M. Kessler
- 👤 Howard E. Smith
- 👤 Aaron Janowsky
- 👤 Jeffrey A. Clanton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:11
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07D207/09
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinylmethyl]-5-iodo-2-methoxybenzamide.
Claim 2
Dependent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinylmethyl]-5-iodo-2-methoxybenzamide.
Claim 3
Dependent Claim
3 words
[ 123 I](R)-N-[(1-4fluorobenzyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide
Claim 4
Dependent Claim
3 words
[ 123 I](R)-N-[(1-4fluorobenzyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide
Claim 5
Dependent Claim
3 words
[ 123 I](S)-N-[1-ethyl-2-pyrrolidinyl)methyl]-5-chloro-3-iodo-6-methoxysalicylamide.
Claim 6
Dependent Claim
3 words
[ 123 I](S)-N-[1-ethyl-2-pyrrolidinyl)methyl]-5-chloro-3-iodo-6-methoxysalicylamide.
Claim 7
Dependent Claim
3 words
[ 123 I](R)-N-[1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl]5-iodo-2,3-dimethoxybenzamide.
Claim 8
Dependent Claim
3 words
[ 123 I](R)-N-[1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl]5-iodo-2,3-dimethoxybenzamide.
Claim 9
Dependent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2,3-dimethoxybenzamide.
Claim 10
Dependent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2,3-dimethoxybenzamide.
Claim 11
Dependent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-5,6-dimethoxysalicylamide.
Claim 12
Dependent Claim
3 words
[ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-5,6-dimethoxysalicylamide.
Claim 13
Independent Claim
43 words
A method of radioimaging a human brain comprising the steps of: (a) systematically applying a radioiodinated substituted benzamine selected from the group consisting of [ 123 I](S)-N-[(1-ethyl-2-pyrrolidinylmethyl]-5-iodo-2-methoxy-benzamide; ( 123 I](R)-N-[1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide; [ 123 I](S)-5-chloro-N-[1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-6-methoxysalicylamide; [ 123 I](R)-N-[(1-(4-fluorophenyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide; and [ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-5,6-dimethoxysalicylamide; [ 123 I](R)-N-[(1-ethyl-w-pyrrolidinyl)methyl]-5-iodo-2,3-dimethoxy-benzamide.
Claim 14
Independent Claim
43 words
A method of radioimaging a human brain comprising the steps of: (a) systematically applying a radioiodinated substituted benzamine selected from the group consisting of [ 123 I](S)-N-[(1-ethyl-2-pyrrolidinylmethyl]-5-iodo-2-methoxy-benzamide; ( 123 I](R)-N-[1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide; [ 123 I](S)-5-chloro-N-[1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-6-methoxysalicylamide; [ 123 I](R)-N-[(1-(4-fluorophenyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide; and [ 123 I](S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-iodo-5,6-dimethoxysalicylamide; [ 123 I](R)-N-[(1-ethyl-w-pyrrolidinyl)methyl]-5-iodo-2,3-dimethoxy-benzamide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-13 | 1996-04-13 | 1996-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-13 | 2000-04-13 | 2000-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-13 | 2004-04-13 | 2004-10-13 | $7700.00 | Window Closed / Lapsed |