US5153219A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thiocarbamate sulfoxide composition for deterring ethanol ingestion
Assignee: Individual
•
Filing: 1991-04-22
•
Granted: 1992-10-06
•
Expires: 2011-04-22
Abstract
Abstract A method is provided for deterring ethanol ingestion by a human, comprising administering to said human an amount of a compound of the formula (R 1 ) R 2 )NC(X)S(O)R 3 effective to cause the disulfiram-ethanol reaction in said human, wherein R 1 , R 2 and R 3 are each (C 1 -C 4 ) alkyl groups, e.g., methyl, ethyl, propyl, isopropyl, butyl, i-butyl and t-butyl.
Inventors
- 👤 Morris D. Faiman
- 👤 Bruce W. Hart
- 👤 Ajay Madan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 10:52
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/145; A61K31/325; A61P; A61P25/00; A61P25/30; A61P25/32; A61P3/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
74 words
A method for deterring ethanol ingestion by a human comprising administering to said human a pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR2## wherein R 1 , R 2 and R 3 are individually (C 1 -C 4 ) alkyl, X is O or S, and the pharmaceutically acceptable salts thereof, which is effective to increase the blood acetaldehyde concentration of said human in the presence of ethanol.
Claim 2
Independent Claim
74 words
A method for deterring ethanol ingestion by a human comprising administering to said human a pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR2## wherein R 1 , R 2 and R 3 are individually (C 1 -C 4 ) alkyl, X is O or S, and the pharmaceutically acceptable salts thereof, which is effective to increase the blood acetaldehyde concentration of said human in the presence of ethanol.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein X is S.
Claim 4
Dependent Claim
9 words
The method of claim 1 wherein X is O.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein R 1 and R 2 are individually methyl or ethyl.
Claim 6
Dependent Claim
10 words
The method of claim 4 wherein R 3 is methyl.
Claim 7
Dependent Claim
11 words
The method of claim 4 wherein the compound is S-methyl-N,N-diethylthiolcarbamate sulfoxide.
Claim 8
Dependent Claim
11 words
The method of claim 2 wherein the compound is S-methyl-N,N-diethyldithiocarbamate sulfoxide.
Claim 9
Dependent Claim
64 words
A pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR3## wherein R 1 and R 2 are individually methyl or ethyl, X is S or O, and the pharmaceutically-acceptable salts thereof; in combination with a pharmaceutically-acceptable carrier, wherein said amount is effective to increase the blood acetaldehyde concentration of a human in the presence of ethanol following administration thereto.
Claim 10
Dependent Claim
64 words
A pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR3## wherein R 1 and R 2 are individually methyl or ethyl, X is S or O, and the pharmaceutically-acceptable salts thereof; in combination with a pharmaceutically-acceptable carrier, wherein said amount is effective to increase the blood acetaldehyde concentration of a human in the presence of ethanol following administration thereto.
Claim 11
Dependent Claim
14 words
The pharmaceutical unit dosage form of claim 8, wherein the compound is S-methyl-N,N-diethylthiolcarbamate sulfoxide.
Claim 12
Dependent Claim
14 words
The pharmaceutical unit dosage form of claim 8, wherein the compound is S-methyl-N,N-diethyldithiocarbamate sulfoxide.
Claim 13
Dependent Claim
14 words
The pharmaceutical unit dosage form of claim 8 wherein R 1 =R 2 =ethyl.
Claim 14
Dependent Claim
12 words
The pharmaceutical unit dosage form of claim 8 wherein X is O.
Claim 15
Dependent Claim
12 words
The pharmaceutical unit dosage form of claim 8 wherein X is S.
Claim 16
Dependent Claim
16 words
The pharmaceutical unit dosage form of claim 8 wherein the pharmaceutically-acceptable carrier is a liquid diluent.
Claim 17
Dependent Claim
17 words
The pharmaceutical unit dosage form of claim 8 wherein the pharmaceutically acceptable carrier is an ingestible capsule.
References Cited (Backward Citations)
US4565689A
Cited
WO1989009208A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-06 | 1996-04-06 | 1996-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-06 | 2000-04-06 | 2000-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-06 | 2004-04-06 | 2004-10-06 | $7700.00 | Window Closed / Lapsed |