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US5152784A Expired / Lapsed US ⏱️ 0.0 years remaining

Prosthetic devices coated with a polypeptide with type IV collagen activity

Assignee: University of Minnesota System
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Filing: 1991-05-22
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Granted: 1992-10-06
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Expires: 2011-05-22
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Abstract

Abstract A polypeptide having the following formula is provided: gly-glu-phe-tyr-phe-asp-leu-arg-leu-lys-gly-asp-lys which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

Inventors

  • 👤 Photini-Effie C. Tsilibary

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 22:33
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 22 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a composition comprising a polypeptide of the formula: gly-glu-phe-tyr-phe-asp-leu-arg-leu-lys-gly-asp-lys.
Claim 2
Dependent Claim 22 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a composition comprising a polypeptide of the formula: gly-glu-phe-tyr-phe-asp-leu-arg-leu-lys-gly-asp-lys.
Claim 3
Dependent Claim 16 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a vascular graft.
Claim 4
Dependent Claim 16 words
The prosthetic device of claim 1, wherein said surface is made of a synthetic resin fiber.
Claim 5
Dependent Claim 17 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of an intraocular contact lens.
Claim 6
Dependent Claim 17 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a hip replacement implant.
Claim 7
Dependent Claim 16 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a percutaneous device.
Claim 8
Dependent Claim 23 words
A prosthetic device in accordance with claim 3, wherein said synthetic resin fiber is selected from the group consisting of nitrocellulose or polyester.
Claim 9
Dependent Claim 17 words
A prosthetic device in accordance with claim 3, wherein said synthetic resin fiber is a polyethylene terephthalate.

References Cited (Backward Citations)

US4578079A Cited
US4870160A Cited
US4876332A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-10-06 1996-04-06 1996-10-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-10-06 2000-04-06 2000-10-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-10-06 2004-04-06 2004-10-06 $7700.00 Window Closed / Lapsed

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