Patent US5152287A successfully refreshed from Google Patents.
US5152287A
Expired / Lapsed
US
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Cross-linked fluorinated polymers for use in gas sensors
Assignee: Cordis Corp
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Filing: 1990-08-15
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Granted: 1992-10-06
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Expires: 2010-08-15
Abstract
Abstract A chemical sensor matrix is provided for use in medical, biological and industrial applications. The gas sensor includes a cross-linked fluoropolymer matrix of a composite having a gas-sensitive indicator within the matrix. The composite includes a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent. Gas-sensitive indicator components which are suitable for detecting gases such as oxygen, carbon dioxide and the like represent indicators suitable for incorporation into the cross-linked fluoropolymer matrix.
Inventors
- 👤 James A. Kane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:12
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; G01N2021/7706; G01N2021/772; G01N2021/773; G01N21/78; G01N21/783
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
236 words
A gas sensor device comprising: an optical waveguide having a distal end portion for monitoring a gas component within a bloodstream or the like, said optical waveguide further including a proximal end portion for communication with means for receiving a signal from said distal end portion; said distal end portion has gas sensor means including a cross-linked fluoropolymer matrix having a gas-sensitive indicator therewithin; and said matrix is a composite formed by cross-linking a composition including between about 60 and about 90 weight percent of a highly fluorinated monofunctional acrylate monomer and between about 10 and about 40 weight percent of a multifunctional acrylate cross-linking agent, all weight percentages being based on the total weight of the composition, wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR2## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality.
Claim 2
Dependent Claim
236 words
A gas sensor device comprising: an optical waveguide having a distal end portion for monitoring a gas component within a bloodstream or the like, said optical waveguide further including a proximal end portion for communication with means for receiving a signal from said distal end portion; said distal end portion has gas sensor means including a cross-linked fluoropolymer matrix having a gas-sensitive indicator therewithin; and said matrix is a composite formed by cross-linking a composition including between about 60 and about 90 weight percent of a highly fluorinated monofunctional acrylate monomer and between about 10 and about 40 weight percent of a multifunctional acrylate cross-linking agent, all weight percentages being based on the total weight of the composition, wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR2## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality.
Claim 3
Dependent Claim
27 words
The device according to claim 1, wherein said gas sensor means is a substantially monolithic membrane which is a cross-linked matrix of said composite and said indicator.
Claim 4
Dependent Claim
27 words
The device according to claim 1, wherein said gas sensor means includes a gas and ion permeable hydrophilic polymer having therewithin microparticles of said cross-linked fluoropolymer matrix.
Claim 5
Dependent Claim
43 words
The device according to claim 1, wherein said gas sensor means includes a gas and ion permeable hydrophilic polymer having therewithin microparticles of said cross-linked fluoropolymer matrix and of a fluorescent indicator for a parameter other than that detected by said gas-sensitive indicator.
Claim 6
Dependent Claim
34 words
The device according to claim 1, wherein said gas sensor means includes microparticles of said cross-linked fluoropolymer matrix, and said microparticles encapsulate a hydrophilic polymer having therewithin an indicator different from said gas-sensitive indicator.
Claim 7
Dependent Claim
21 words
The device according to claim 1, wherein said composite further includes not greater than about 1 weight percent of a photoinitiator.
Claim 8
Dependent Claim
28 words
The device according to claim 1, wherein said monomer is present at between about 75 and about 85 weight percent, based on the total weight of the composition.
Claim 9
Dependent Claim
23 words
The device according to claim 1, wherein said gas-sensitive indicator is a transition metal complex which is sensitive to oxygen or carbon dioxide.
Claim 10
Dependent Claim
208 words
A gas sensor device comprising: an electrochemical gas sensor including gas sensor means for monitoring a gas component within a patient or the like; said gas sensor means includes a gas-sensitive indicator within a cross-linked fluoropolymer matrix; and said matrix is a cross-linked composite of a composition including between about 60 to about 90 weight percent of a highly fluorinated monofunctional acrylate monomer and between about 10 and about 40 weight percent of a multifunctional acrylate cross-linking agent, all weight percentages being based on the total weight of the composition, wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR3## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality.
Claim 11
Dependent Claim
208 words
A gas sensor device comprising: an electrochemical gas sensor including gas sensor means for monitoring a gas component within a patient or the like; said gas sensor means includes a gas-sensitive indicator within a cross-linked fluoropolymer matrix; and said matrix is a cross-linked composite of a composition including between about 60 to about 90 weight percent of a highly fluorinated monofunctional acrylate monomer and between about 10 and about 40 weight percent of a multifunctional acrylate cross-linking agent, all weight percentages being based on the total weight of the composition, wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR3## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality.
Claim 12
Dependent Claim
23 words
The gas sensor device according to claim 9, wherein said composite further includes not greater than about 1 weight percent of a photoinitiator.
Claim 13
Dependent Claim
30 words
The gas sensor device according to claim 9, wherein said monomer is present at between about 75 and about 85 weight percent, based on the total weight of the composition.
Claim 14
Dependent Claim
175 words
A cross-linked gas permeable membrane for a gas sensor device, comprising: a composite including a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent, said composite further having incorporated therewithin a gas-sensitive indicator component; wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR4## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality; and said composite and said indicator incorporated therewithin had been cross-linked and cured into a cross-linked fluoropolymer gas permeable component matrix.
Claim 15
Dependent Claim
175 words
A cross-linked gas permeable membrane for a gas sensor device, comprising: a composite including a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent, said composite further having incorporated therewithin a gas-sensitive indicator component; wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR4## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality; and said composite and said indicator incorporated therewithin had been cross-linked and cured into a cross-linked fluoropolymer gas permeable component matrix.
Claim 16
Dependent Claim
24 words
The membrane according to claim 12, wherein said membrane includes a hydrophilic polymer having dispersed therewithin microparticles of said cross-linked fluoropolymer gas permeable component.
Claim 17
Dependent Claim
41 words
The membrane according to claim 12, wherein said membrane includes a gas and ion permeable hydrophilic polymer having dispersed therewithin microparticles of said cross-linked fluoropolymer component and a fluoroescent indicator for a parameter other than that detected by said gas-sensitive indicator.
Claim 18
Dependent Claim
28 words
The membrane according to claim 12, wherein said monomer is present at between about 75 and about 85 weight percent, based on the total weight of the composition.
Claim 19
Dependent Claim
23 words
The membrane according to claim 12, wherein said gas-sensitive indicator is a transition metal complex which is sensitive to oxygen or carbon dioxide.
Claim 20
Dependent Claim
31 words
The membrane according to claim 12, wherein said monomer is selected from the group consisting of 2-(N-butylperfluorooctanesulfonamido) ethyl acrylate, 2-(N-ethylperfluorooctanesulfonamido) ethyl acrylate, perfluorooctyl acrylate, trihydroperfluoroheptyl acrylate, trihydroperfluoroundecyl acrylate, and nonahydroperfluorodecyl acrylate.
Claim 21
Dependent Claim
177 words
A cross-linked gas permeable microparticle for use within a gas sensor device, comprising: a composite including a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent, said composite further having incorporated therewithin a gas-sensitive indicator component; wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR5## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality; and said composite and said indicator incorporated therewithin had been crosslinked and cured into a cross-linked fluoropolymer gas permeable microparticle matrix.
Claim 22
Dependent Claim
177 words
A cross-linked gas permeable microparticle for use within a gas sensor device, comprising: a composite including a highly fluorinated monofunctional acrylate monomer and a multifunctional acrylate cross-linking agent, said composite further having incorporated therewithin a gas-sensitive indicator component; wherein said highly fluorinated monofunctional acrylate monomer is a component having a formula R(CH 2 ) n O 2 CC 2 H 3 , wherein R is X(CF 2 ) m , where m is from 3 to 12, inclusive, X is H or F; and wherein n is 1, 2 . . . 3 m, or a formula: ##STR5## wherein R' is C M F 2M+1 , where M is 2 or more; wherein R" is CH 3 , C 2 H 5 . . . C 4 H 9 ; and wherein X is H or CH 3 , and wherein said multifunctional acrylate cross-linking agent is a triacrylate or an acrylate of greater acrylate functionality; and said composite and said indicator incorporated therewithin had been crosslinked and cured into a cross-linked fluoropolymer gas permeable microparticle matrix.
Claim 23
Dependent Claim
23 words
The microparticle according to claim 18, wherein said microparticle was formed by polymerizing said monomer, cross-linking agent and indicator component within a fluid.
Claim 24
Dependent Claim
42 words
The microparticle according to claim 18, wherein said microparticle was formed by polymerizing said monomer, cross-linking agent and indicator component between opposing plates to form a polymer sheet, removing the polymer sheet from the plates, and grinding the polymer sheet into microparticles
Claim 25
Dependent Claim
21 words
The microparticle according to claim 18, wherein said composite further includes not greater than about 1 weight percent of a photoinitiator.
Claim 26
Dependent Claim
28 words
The microparticle according to claim 18, wherein said monomer is present at between about 75 and about 85 weight percent, based on the total weight of the composition.
Claim 27
Dependent Claim
31 words
The microparticle according to claim 18, wherein said monomer is selected from the group consisting of 2-(N-butylperfluorooctanesulfonamido) ethyl acrylate, 2-(N-ethylperfluorooctanesulfonamido) ethyl acrylate, perfluorooctyl acrylate, trihydroperfluoroheptyl acrylate, trihydroperfluoroundecyl acrylate, and nonahydroperfluorodecyl acrylate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-10-06 | 1996-04-06 | 1996-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-10-06 | 2000-04-06 | 2000-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-10-06 | 2004-04-06 | 2004-10-06 | $7700.00 | Window Closed / Lapsed |