US5147797A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptides with fibronectin activity
Assignee: University of Minnesota System
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Filing: 1991-08-08
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Granted: 1992-09-15
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Expires: 2011-08-08
Abstract
Abstract A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gl y-val, lys-asn-asn-gln-lys-ser-glu-pro-leu-ileu-gly-arg-lys-lys-thr-asp-glu-leu, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with the polypeptide composition are also provided.
Inventors
- 👤 James B. McCarthy
- 👤 Leo T. Furcht
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:28
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/28; C07K14/46; C07K14/47; C12; C12N; C12N5/00; C12N5/0068; C12N2533/00; C12N2533/50; C12N2533/52
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
24 words
A cell culture substrate having a surface coated with a composition consisting essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gly-val lys-asn-asn-gln-lys-ser-glu-pro-leu-ileu-gly-arg-lys-lys-thr-asp-glu-leu, or mixtures thereof.
Claim 2
Dependent Claim
24 words
A cell culture substrate having a surface coated with a composition consisting essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gly-val lys-asn-asn-gln-lys-ser-glu-pro-leu-ileu-gly-arg-lys-lys-thr-asp-glu-leu, or mixtures thereof.
Claim 3
Dependent Claim
16 words
The cell culture substrate of claim 1 wherein said surface is made of a synthetic resin.
Claim 4
Dependent Claim
16 words
The cell culture substrate of claim 1 wherein said surface constitutes a portion of a bead.
Claim 5
Dependent Claim
17 words
The cell culture medium of claim 1 wherein said surface constitutes a portion of a microporous fiber.
Claim 6
Dependent Claim
17 words
The cell culture medium of claim 1 wherein said surface constitutes the wells of a microtiter plate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-15 | 1996-03-16 | 1996-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-15 | 2000-03-16 | 2000-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-15 | 2004-03-16 | 2004-09-15 | $7700.00 | Window Closed / Lapsed |