Bactericidal formulations for use in veterinary medicine

Abstract

Abstract A method of treating livestock infected with, or protecting livestock against infection from, bacteria which comprises administering to such livestock an antibacterially effective amount of a quinolonecarboxylic acid or derivative of the formula <IMAGE> or <IMAGE> in which A represents nitrogen or =C-R4, R4 represents hydrogen, fluorine, chlorine, nitro or methyl, B represents <IMAGE> and B also represents <IMAGE> when R1 does not denote cyclopropyl, and R5 represents hydrogen, a branched or unbranched alkyl group which has 1 to 4 carbon atoms and which can optionally be substituted by a hydroxyl or methoxy group, R6 represents hydrogen, methyl or phenyl, R7 represents hydrogen or methyl, R8 represents amino, alkyl- or dialkylamino having 1 or 2 carbon atoms in the alkyl group, aminomethyl, alkyl- or dialkylaminomethyl having 1 or 2 carbon atoms in the alkyl group, R1 represents an alkyl radical having 1 to 3 carbon atoms, cyclopropyl, 2-fluoroethyl vinyl, methoxy, 4-fluorophenyl or methylamino, R2 represents hydrogen, alkyl having 1 to 6 carbon atoms, and cyclohexyl, benzyl, 2-oxopropyl, phenacyl and ethoxycarbonylmethyl, R3 represents hydrogen, methyl or ethyl, Z represents oxygen, nitrogen which is substituted by methyl or phenyl, and =CH2-, or a pharmaceutically utilizable salt thereof.

Inventors

• 👤 Karl G. Metzger
• 👤 Hans-Joachim Zeiler
• 👤 Martin Scheer
• 👤 Herbert Voege
• 👤 Klaus Grohe

Bibliographic Details