Patent US5133957A successfully refreshed from Google Patents.
US5133957A
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Composition and method for desensitizing dentin
Assignee: Bisco Inc
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Filing: 1991-09-18
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Granted: 1992-07-28
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Expires: 2011-09-18
Abstract
Abstract Hypersensitive dentin or cementum is treated by applying thereto two copolymerizable monomers which are polymerized in place and function to desensitize the hypersensitive areas. The first copolymerizable monomer used in the invention is the reaction product of N-phenylglycine or N- (p-tolyl)glycine and glycidyl methacrylate (NPG-GMA or NTG-GMA). The second copolymerizable monomer is selected from certain compounds produced by the reaction of an acid anhydride with excess hydroxyethyl methacrylate, e.g., biphenyl dimethacrylate. In a preferred embodiment, the mixture of monomers also contains a photosensitizer, such as camphoroquinone, which makes the mixture photocurable in addition to self-curable.
Inventors
- 👤 Byoung I. Suh
- 👤 Martin Hamer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:25
CPC Classifications
A; A61; A61K; A61K6/00; A61K6/60; A61K6/62; A61K6/20; A61K6/40; Y; Y10; Y10S; Y10S522/00; Y10S522/908
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
219 words
A method of desensitizing hypersensitive dentin or cementum comprising applying to said dentin or cementum effective amounts of hydrophilic copolymerizable monomers A and B in solution in a water-displacing organic solvent, said monomers being applied simultaneously in a single solution or consecutively in separate solutions, and polymerizing said monomers to form an adhesive protective film thereon, monomer A being selected from the group consisting of the reaction products of N-phenyl glycine or N-(p-tolyl) glycine with glycidyl methacrylate, and alkali metal salts thereof, monomer B being selected from the group having the formulas ##STR11## wherein R is oxygen or --CH 2 ) n and n is 0, 1, or 2; ##STR12## wherein R 1 is N or --CH═ and m is 1 or 2; ##STR13## wherein X is ##STR14## R 2 and R 3 are the same or different, and are selected from hydrogen and C 1 -C 3 alkyl, and p is 0 or 1; ##STR15## wherein R 4 is --CH 2 ) n and n is 1 or 2; ##STR16## wherein one of Y 1 and Y 2 and one of Y 3 and Y 4 is hydrogen and the other is ##STR17## and ##STR18## wherein one of Y 1 and Y 2 and one of Y 3 and Y 4 is hydrogen and the other is ##STR19##
Claim 2
Independent Claim
219 words
A method of desensitizing hypersensitive dentin or cementum comprising applying to said dentin or cementum effective amounts of hydrophilic copolymerizable monomers A and B in solution in a water-displacing organic solvent, said monomers being applied simultaneously in a single solution or consecutively in separate solutions, and polymerizing said monomers to form an adhesive protective film thereon, monomer A being selected from the group consisting of the reaction products of N-phenyl glycine or N-(p-tolyl) glycine with glycidyl methacrylate, and alkali metal salts thereof, monomer B being selected from the group having the formulas ##STR11## wherein R is oxygen or --CH 2 ) n and n is 0, 1, or 2; ##STR12## wherein R 1 is N or --CH═ and m is 1 or 2; ##STR13## wherein X is ##STR14## R 2 and R 3 are the same or different, and are selected from hydrogen and C 1 -C 3 alkyl, and p is 0 or 1; ##STR15## wherein R 4 is --CH 2 ) n and n is 1 or 2; ##STR16## wherein one of Y 1 and Y 2 and one of Y 3 and Y 4 is hydrogen and the other is ##STR17## and ##STR18## wherein one of Y 1 and Y 2 and one of Y 3 and Y 4 is hydrogen and the other is ##STR19##
Claim 3
Dependent Claim
39 words
The method of claim 1 wherein said monomers are applied as a single solution containing 1-50% by weight of monomers A and B the weight ratio of monomer A to monomer B being within the range 1:1 to 1:50.
Claim 4
Dependent Claim
33 words
The method of claim 2 wherein said solution contains 10-30% by weight of monomers A and B, the weight ratio of monomer A to monomer B being within the range 1:5 to 1:20.
Claim 5
Dependent Claim
24 words
The method of claim 1 wherein said solvent is selected from organic solvents miscible with at least 25% by of water at ambient temperature.
Claim 6
Dependent Claim
18 words
The method of claim 3 wherein said solvent is selected from acetone and C 1 -C 4 alkanols.
Claim 7
Dependent Claim
27 words
The method of claim 1 wherein at least one of said solutions contains in addition an effective amount of a photosensitizer whereby said monomers are rendered photocurable.
Claim 8
Dependent Claim
10 words
The method of claim 6 wherein said photosensitizer is camphoroquinone.
Claim 9
Dependent Claim
29 words
The method of claim 1 wherein said hypersensitive dentin and cementum are pretreated with a conditioning agent comprising 1 to 50% phosphoric acid prior to application of said monomers.
Claim 10
Dependent Claim
16 words
The method of claim 8 wherein said conditioning agent comprises 5 to 15% of phosphoric acid.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-07-28 | 1996-01-27 | 1996-07-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-28 | 2000-01-27 | 2000-07-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-28 | 2004-01-27 | 2004-07-28 | $7700.00 | Window Closed / Lapsed |