Patent US5132115A successfully refreshed from Google Patents.
US5132115A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Planar therapeutic system, process for its production and utilization
Assignee: Lohmann GmbH and Co KG
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Filing: 1987-04-16
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Granted: 1992-07-21
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Expires: 2007-04-16
Abstract
Abstract A transdermal therapeutic system is disclosed which comprises an optional flexible backing layer, one or more drug reservoir(s), one or more adhesive layer(s) and optionally a detachable protective layer for the skin contact surface of the flat therapeutical system. The skin contact area of the therapeutical system is a skin contact layer which has one or more non-adhesive drug-releasing section(s) and one or more skin-adhesion section(s), which optionally contain a further drug. A process is disclosed for the production of the system, as well as the use thereof for local or systemic, transdermal administration of drugs in human or veterinary medicine or in cosmetics.
Inventors
- 👤 Karin Wolter
- 👤 Fritz Herrmann
- 👤 Hans R. Hoffmann
- 👤 Gunter Simon
- 👤 Thomas Kissel
- 👤 Joerg Reinhardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:39
CPC Classifications
A; A61; A61M; A61M37/00; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A45; A45D; A45D34/00; A45D44/00; A61K8/00; A61K8/02; A61K8/0208; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K9/7084; A61K9/7092; A61Q; A61Q19/00
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
109 words
A multi-component planar therapeutic system for securement to skin and transdermal administration of drugs, said system comprising a planar skin contact area, said skin contact area comprising a drug-releasing component and an adhesive component presenting respective transdermal transfer and skin adhesion surfaces over said skin contact area in the same level said drug-releasing component forming part of a drug containing reservoir and wherein at least one of said drug-releasing component and said adhesive component is divided into discrete sections distributed over the entirety of said skin contact area to thereby ensure constant contact of said drug-releasing component with a region of skin for transdermal drug administration to the subject.
Claim 2
Dependent Claim
109 words
A multi-component planar therapeutic system for securement to skin and transdermal administration of drugs, said system comprising a planar skin contact area, said skin contact area comprising a drug-releasing component and an adhesive component presenting respective transdermal transfer and skin adhesion surfaces over said skin contact area in the same level said drug-releasing component forming part of a drug containing reservoir and wherein at least one of said drug-releasing component and said adhesive component is divided into discrete sections distributed over the entirety of said skin contact area to thereby ensure constant contact of said drug-releasing component with a region of skin for transdermal drug administration to the subject.
Claim 3
Dependent Claim
20 words
A planar therapeutic system according to claim 1, characterized by having discrete drug-releasing sections distributed over the skin contact area.
Claim 4
Dependent Claim
18 words
A planar therapeutic system according to claim 1, characterized by having drug-releasing sections which are circular in area.
Claim 5
Dependent Claim
18 words
A planar therapeutic system according to claim 1, characterized by having adhesive sections which are circular in area.
Claim 6
Dependent Claim
23 words
A planar therapeutic system accoding to claim 1, characterized by having adhesive sections and drug-releasing sections arranged in strips alternating side by side.
Claim 7
Dependent Claim
24 words
A planar therapeutic system according to claim 1 characterized in that said skin contact area is provided with a peripheral skin adhesion edge portion.
Claim 8
Dependent Claim
28 words
A planar therapeutic system according to claim 1, characterized in that it further includes a flexible backing layer facing away from the skin contact area of said system.
Claim 9
Dependent Claim
25 words
A planar therapeutic system acording to claim 7, characterized further by an adhesive intermediate layer disposed between the flexible backing layer and the drug-releasing component.
Claim 10
Dependent Claim
23 words
A planar therapeutic system according to claim 1, characterized by further including a supporting layer with openings in contact with the drug-releasing component.
Claim 11
Dependent Claim
35 words
A planar therapeutic system according to claim 9, characterized in that the supporting layer is formed of flexible material selected from the group consisting of paper, textile sheet, metal film, plastic film and laminates thereof.
Claim 12
Dependent Claim
25 words
A planar therapeutic system according to claim 9, characterized in that there is an adhesive component situated between the supporting layer and the drug-releasing component.
Claim 13
Dependent Claim
22 words
A planar therapeutic system according to claim 1, characterized in that the drug-releasing component contains at least one drug having topical action.
Claim 14
Dependent Claim
79 words
A planar therapeutic system according to claim 1, characterized in that the drug is comprised of the combination of a cardiac glycoside and a compound selected from the group consisting of vasodilators, musculotropic spasmolytics, coronary therapeutics and coronary vasodilators; an antihistamine and a compound selected from the group consisting of analeptics, analgesics, antipyretics, hypnotics, anaesthetics, antiseptics, musculotropic vasodilators, lipid lowering agents and vitamin B6; theophylline and compounds and derivatives thereof; and rubefacients and free bases, salts and derivatives thereof.
Claim 15
Dependent Claim
52 words
A planar therapeutic system according to claim 1, characterized in that the drug is selected from the group consisting of amphetaminil, betahistine, betaacetyldigoxin, bopindolol, buprenorphine, clemastine, diclofenac, diltiazen, dimenhydrinate, diethylamine salicylate, ethyleneglycol, monosalicylate, 5-fluorouracil, glibenclamide, hydromorphone, ibuprofen, isopropyl-4-(2,1,3-benzoxydiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridine-carboxylate, ketofin, L-thyroxine, nicotine, nicotinic acid-β-butoxyethylester, nonyl acid vanillylamide, pindolol, salbutamol, tamoxifin, tizanidine and theophylline.
Claim 16
Dependent Claim
44 words
A planar therapeutic system according to claim 1, characterized in that the drug of the drug-releasing component comprises a combination of a cardiac glycoside of digitales lanata-β-acetyldigoxin and a compound selected from the group consisting of vasodilators, musculotropic spasmolytics, coronary therapeutics and coronary vasodilators.
Claim 17
Dependent Claim
26 words
A planar therapeutic system according to claim 1, characterized in that the drug of the drug-releasing component comprises a combination of an antihistamine with a glucocorticoid.
Claim 18
Dependent Claim
33 words
A planar therapeutic system according to claim 1, characterized in that the drug of the drug-releasing component comprises a combination of a broncholytic, cardiac, diuretic, phospho-diesterase inhibitor, theophylline and compounds and derivatives thereof.
Claim 19
Dependent Claim
23 words
A planar therapeutic system according to claim 1, wherein the drug of the drug-releasing component comprises a rubefacient in combination with an antiphlogistic.
Claim 20
Dependent Claim
33 words
A planar therapeutic system according to claim 1, characterized in that at least one drug is present in the drug-releasing component and at least one other drug is present in the adhesive component.
Claim 21
Dependent Claim
21 words
A planar therapeutic system according to claim 1, characterized in that the adhesive component comprises nitroglycerine as an active agent thereof.
Claim 22
Dependent Claim
79 words
A process for the production of a planar therapeutic system as defined in claim 1, which comprises: providing a base layer for application of adhesive thereon; producing an adhesive component layer on the base layer; layering a support material thereon; perforating the laminate thus formed; exchanging the base layer for a detachable protective layer; coating the surface which is away from the protective layer with a drug containing reservoir mass; lining a backing layer thereon; and packaging the system.
Claim 23
Dependent Claim
45 words
A process for the production of a planar therapeutic system according to claim 16, characterized in that after perforating the laminate, a coating of the drug-releasing component is made by lining with a drug-releasing component produced on the backing layer by the application of pressure.
Claim 24
Dependent Claim
59 words
A process for the production of a planar therapeutic system as defined in claim 1 which comprises: applying discrete adhesive sections onto a protective base layer; coating the adhesive sections and protective base layer with the drug containing reservoir; lining a backing layer which optionally has an adhesive finish over the drug containing reservoir; and packaging the resulting system.
Claim 25
Dependent Claim
33 words
The process of using a planar therapeutic system according to claim 1 comprising applying the system for the local or systemic transdermal administration of drugs in human and veterinary medicine and in cosmetics.
Claim 26
Dependent Claim
18 words
A planar therapeutic system according to claim 1, characterized by having drug-releasing sections which are square in area.
Claim 27
Dependent Claim
18 words
A planar therapeutic system according to claim 1, characterized by having adhesive sections which are square in area.
Claim 28
Dependent Claim
16 words
A planar therapeutic system according to claim 7, further characterized by including a removable protective layer.
Claim 29
Dependent Claim
23 words
A planar therapeutic system according to claim 1, further characterized in that the drug-releasing component contains at least one drug having systemic action.
Claim 30
Dependent Claim
18 words
A planar therapeutic system according to claim 16, wherein the antihistamine is clemastin and the glucocorticoid is dexamethason.
Claim 31
Dependent Claim
35 words
A planar therapeutic system according to claim 1, wherein the drug comprises a combination of an antihistamine and a compound selected from the group consisting of vasodilators, analeptics, analgesics, hypnotics, musculotropic vasodilators, and vitamin B6.
Claim 32
Dependent Claim
13 words
A planar therapeutic system according to claim 30, wherein the antihistamine is antiemeticum-dimenhydrinate.
Claim 33
Dependent Claim
26 words
A planar therapeutic system according to claim 1, characterized in that the drug comprises a combination of a broncholytic, cardiac, diuretic, phospho-diesterase inhibitor and theophylline derivatives.
Claim 34
Dependent Claim
17 words
A planar therapeutic system according to claim 17, wherein the broncholytic, cardiac, diuretic, phospho-diesterase inhibitor is theophylline.
Claim 35
Dependent Claim
38 words
A planar therapeutic system according to claim 18, wherein the rubefacient is selected from the group consisting of nicotinic acid-β-butoxyethylester, nonyl acid vanillylamide and the antiphlogistic is selected from the group consisting of ethyleneglycol monosalicylate and diethylamine salicylate.
Claim 36
Dependent Claim
33 words
A process for the production of a planar therapeutic system according to claim 22, further characterized by applying heat along with the pressure to produce a coating of the drug containing reservoir mass.
Claim 37
Dependent Claim
137 words
A multi-component planar therapeutic system for securement to skin and transdermal administration of drugs, said system comprising a planar skin contact area, said skin contact area comprising a drug-releasing component and an adhesive component presenting respective transdermal transfer and skin adhesion surfaces over said skin contact area in the same level said drug-releasing component comprising a drug containing reservoir, and wherein at least one of said drug-releasing component and said adhesive component is divided into discrete sections distributed over the entirety of said skin contact area, each of said discrete sections being separated by surfaces of the other of said components, the surfaces of the discrete sections and separating surfaces all being at said same level thereby to ensure constant contact of said drug-releasing component with said region of skin for transdermal drug administration to the subject.
Claim 38
Dependent Claim
137 words
A multi-component planar therapeutic system for securement to skin and transdermal administration of drugs, said system comprising a planar skin contact area, said skin contact area comprising a drug-releasing component and an adhesive component presenting respective transdermal transfer and skin adhesion surfaces over said skin contact area in the same level said drug-releasing component comprising a drug containing reservoir, and wherein at least one of said drug-releasing component and said adhesive component is divided into discrete sections distributed over the entirety of said skin contact area, each of said discrete sections being separated by surfaces of the other of said components, the surfaces of the discrete sections and separating surfaces all being at said same level thereby to ensure constant contact of said drug-releasing component with said region of skin for transdermal drug administration to the subject.
Claim 39
Dependent Claim
23 words
A planar therapeutic system according to claim 36 wherein said discrete sections are isolated from each other by regions of the other component.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-21 | 1996-01-20 | 1996-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-21 | 2000-01-20 | 2000-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-21 | 2004-01-20 | 2004-07-21 | $7700.00 | Window Closed / Lapsed |