Liquid chromatograph

Claim 2

A liquid chromatograph comprising: an analyzing chip for analyzing a liquid sample, said analyzing chip including a substrate having a capillary groove formed therein, detecting means disposed downstream of said capillary groove, and a cover covering said capillary groove, thereby forming a capillary having an inlet and an outlet; a frame member constituting an outer valve member and having formed therein a liquid sample introduction path, a carrier liquid introduction path, and a liquid discharge path; and a rigid member in which said analyzing chip is mounted, said rigid member constituting an inner valve member and being movably disposed within said frame member to enable said inlet and said outlet of said capillary to be selectively connected to and disconnected from said liquid sample introduction path, said carrier liquid introduction path, and said liquid discharge path when said rigid member is moved relative to said frame member.

Claim 3

A liquid chromatograph according to claim 1, wherein the capillary groove has an inner diameter of 0.5 to 50 micrometers, and the liquid sample introduction path has an inner diameter 10 or more times larger than the inner diameter of the capillary groove.

Claim 4

A liquid chromatograph according to claim 3, wherein the detecting means is an FET-type chemical sensor for detecting component ions contained in the liquid sample, and wherein a wall surface of a part of the capillary groove serves as a gate insulative membrane of the FET-type chemical sensor.

Claim 5

A liquid chromatograph comprising: an analyzing chip for analyzing a liquid sample, said analyzing chip including a substrate having a capillary groove formed therein for conveying a carrier liquid, detecting means connected to said capillary groove, and a cover covering said capillary groove to form a capillary; a frame member within which said analyzing chip is disposed; and carrier liquid feeding means disposed outside said frame member for feeding said carrier liquid into said capillary; wherein said analyzing chip is clamped between disc-shaped rigid members to form a rotor, said rotor being rotatably disposed within said frame member to enable flow paths in said liquid chromatograph to be changed by rotating said rotor.

Claim 6

A liquid chromatograph comprising: an analyzing chip for analyzing a liquid sample, said analyzing chip including a substrate having a capillary groove formed therein for conveying a carrier liquid, detecting means connected to said capillary groove, and a cover covering said capillary groove to form a capillary; a frame member within which said analyzing chip is disposed; and carrier liquid feeding means disposed outside said frame member for feeding said carrier liquid into said capillary; wherein said analyzing chip is clamped between disc-shaped rigid members to form a rotor, said rotor being rotatably disposed within said frame member to enable flow paths in said liquid chromatograph to be changed by rotating said rotor.

Claim 7

The liquid chromatograph according to claim 2, wherein said capillary groove is subjected to a surface treatment suitable for enabling separation of components of said liquid sample after said capillary groove is formed in said substrate.

Claim 8

The liquid chromatograph according to claim 2, wherein said detecting means comprises detection terminals of an electrochemical detector or an electrical conductivity detector.

Claim 9

A liquid chromatograph comprising: a frame member having an inner space and being provided with a liquid sample introduction hole for conveying a liquid sample to be analyzed by liquid chromatography from outside the frame member to the inner space, a carrier liquid introduction hole for conveying a carrier liquid from outside the frame member to the inner space, and a liquid discharge hole for conveying the liquid sample and the carrier liquid from the inner space to outside the frame member; and a rotor valve body disposed within the inner space of the frame member so as to be rotatable relative to the frame member and to form a liquid-tight seal with at least one surface of the inner space of the frame member, the rotor valve body having mounted therein an analyzing chip for analyzing the liquid sample by liquid chromatography; the analyzing chip comprising: a substrate having a principal surface and a capillary groove formed in the principal surface; a cover plate sealed to the principal surface of the substrate to form a liquid-tight seal with the principal surface of the substrate and to establish a capillary column for liquid chromatography in cooperation with the capillary groove; and detecting means connected to a downstream end of the capillary column for detecting components of the liquid sample in the form of a liquid chromatogram; wherein the rotor valve body has an outer surface provided with first, second, third, and fourth holes, the first and second holes being connected with the capillary column and the third and fourth holes being connected with each other, and wherein the rotor valve body is rotatable to a plurality of rotational positions to selectively connect three holes selected from the first, second, third, and fourth holes with the liquid sample introduction hole, the carrier liquid introduction hole, and the liquid discharge hole in the frame member.

Claim 10

A liquid chromatograph comprising: a frame member having an inner space and being provided with a liquid sample introduction hole for conveying a liquid sample to be analyzed by liquid chromatography from outside the frame member to the inner space, a carrier liquid introduction hole for conveying a carrier liquid from outside the frame member to the inner space, and a liquid discharge hole for conveying the liquid sample and the carrier liquid from the inner space to outside the frame member; and a rotor valve body disposed within the inner space of the frame member so as to be rotatable relative to the frame member and to form a liquid-tight seal with at least one surface of the inner space of the frame member, the rotor valve body having mounted therein an analyzing chip for analyzing the liquid sample by liquid chromatography; the analyzing chip comprising: a substrate having a principal surface and a capillary groove formed in the principal surface; a cover plate sealed to the principal surface of the substrate to form a liquid-tight seal with the principal surface of the substrate and to establish a capillary column for liquid chromatography in cooperation with the capillary groove; and detecting means connected to a downstream end of the capillary column for detecting components of the liquid sample in the form of a liquid chromatogram; wherein the rotor valve body has an outer surface provided with first, second, third, and fourth holes, the first and second holes being connected with the capillary column and the third and fourth holes being connected with each other, and wherein the rotor valve body is rotatable to a plurality of rotational positions to selectively connect three holes selected from the first, second, third, and fourth holes with the liquid sample introduction hole, the carrier liquid introduction hole, and the liquid discharge hole in the frame member.