Patent US5130231A successfully refreshed from Google Patents.
US5130231A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood plasma test device including a semipermeable membrane made of an expanded hydrophobic material that has been treated with a surfactant
Assignee: Chem-Elec Inc
•
Filing: 1989-06-12
•
Granted: 1992-07-14
•
Expires: 2009-06-12
Abstract
Abstract Single or multiple blood plasma component concentrations are measured by a disposable stick having one or more blood plasma component reactive areas covered by a semipermeable membrane which is permeable by blood plasma or serum components and impermeable by blood cellular and particulate matter. A second overlay may be superposed with the semipermeable membrane over the reactive areas to receive a blood sample and meter and distribute that sample uniformly to the semipermeable membrane which in turn passes the plasma components uniformly to the reactive areas. The overlays are subsequently separable from the reactive area to remove the cellular components and particulate matter and expose the reactive areas for inspection by, for example, color comparison to standardized charts.
Inventors
- 👤 Paul R. Kennedy
- 👤 Ernest C. Adams
- 👤 William E. Woenke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:01
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q1/58; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5002; G01N33/52; C12Q2326/00; C12Q2326/10; C12Q2326/12; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
37 words
A blood component level determination stick comprising a supporting strip, a reactive pad disposed on the supporting strip, and a hydrophobic semipermeable membrane with hydrophilic pores formed of an expanded polytetrafluoroethylene material superposed over the reactive pad.
Claim 2
Dependent Claim
37 words
A blood component level determination stick comprising a supporting strip, a reactive pad disposed on the supporting strip, and a hydrophobic semipermeable membrane with hydrophilic pores formed of an expanded polytetrafluoroethylene material superposed over the reactive pad.
Claim 3
Dependent Claim
23 words
The stick of claim 1 further including an absorbent overlay for receiving, spreading, and metering an applied blood sample to the semipermeable membrane.
Claim 4
Dependent Claim
63 words
The stick of claim 1 wherein the reactive pad contains an enzyme for catalyzing a reaction converting a selected blood component and generating hydrogen peroxide as a result of that conversion, a peroxidatively active material, and an indicator material which is oxidized by hydrogen peroxide in the presence of the peroxidatively active material providing a component indicative color change in the indicator material.
Claim 5
Dependent Claim
17 words
The stick of claim 1 wherein the reactive pad contains glucose oxidase, peroxidase, and an indicator material.
Claim 6
Dependent Claim
19 words
The stick of claim 1 wherein the reactive pad contains cholesterol oxidase, cholesterol esterase, peroxidase, and an indicator material.
Claim 7
Dependent Claim
16 words
The stick of claim 1 wherein the reactive pad contains uricase, peroxidase, and an indicator material.
Claim 8
Dependent Claim
17 words
The stick of claim 1 wherein the reactive pad contains alcohol oxidase, peroxidase and an indicator material.
Claim 9
Dependent Claim
16 words
The stick of claim 1 wherein the reactive pad contains urease, and a pH indicator material.
Claim 10
Dependent Claim
75 words
A disposable blood component level measuring arrangement comprising a blood plasma component reactive area, and an overlay formed of a hydrophobic expanded polytetrafluoroethylene containing material which has been treated with a surfactant to make the pores hydrophilic, the overlay being permeable by blood plasma components and impermeable by blood cellular components, the overlay being superposed over the reactive layer to receive a blood sample and subsequently separable therefrom to expose the reactive area for inspection.
Claim 11
Dependent Claim
75 words
A disposable blood component level measuring arrangement comprising a blood plasma component reactive area, and an overlay formed of a hydrophobic expanded polytetrafluoroethylene containing material which has been treated with a surfactant to make the pores hydrophilic, the overlay being permeable by blood plasma components and impermeable by blood cellular components, the overlay being superposed over the reactive layer to receive a blood sample and subsequently separable therefrom to expose the reactive area for inspection.
Claim 12
Dependent Claim
22 words
The measuring arrangement of claim 9 wherein the material is particle size discriminatory having pore sizes ranging from 0.2 to 15 microns.
Claim 13
Dependent Claim
32 words
The measuring arrangement of claim 9 wherein the reactive area comprises a plurality of discrete subareas, each having a chemical composition different from the others and reacting with different blood plasma components.
Claim 14
Dependent Claim
56 words
A blood cholesterol level determination stick comprising a supporting strip, a reactive pad containing cholesterol oxidase, cholesterol esterase, peroxidase and an indicator material disposed on the supporting strip; and a semipermeable membrane formed of an expanded porous hydrophobic material which has been treated with a surfactant to make the material hydrophilic superposed over the reactive pad.
Claim 15
Dependent Claim
56 words
A blood cholesterol level determination stick comprising a supporting strip, a reactive pad containing cholesterol oxidase, cholesterol esterase, peroxidase and an indicator material disposed on the supporting strip; and a semipermeable membrane formed of an expanded porous hydrophobic material which has been treated with a surfactant to make the material hydrophilic superposed over the reactive pad.
References Cited (Backward Citations)
US3092465A
Cited
US3368872A
Cited
US3992158A
Cited
US3983005A
Cited
US4066403A
Cited
US4248924A
Cited
US4144306A
Cited
US4223089A
Cited
US4292272A
Cited
US4613441A
Cited
US4477575A
Cited
US4477575B1
Cited
US4476222A
Cited
US4501785A
Cited
US4501793A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-14 | 1996-01-13 | 1996-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-14 | 2000-01-13 | 2000-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-14 | 2004-01-13 | 2004-07-14 | $7700.00 | Window Closed / Lapsed |