US5126440A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Iodinated polymers with dextran skeleton, processes for their preparation and their uses as contrast products
Assignee: Guerbet SA
•
Filing: 1989-08-10
•
Granted: 1992-06-30
•
Expires: 2009-08-10
Abstract
Abstract PCT No. PCT/FR89/00409 Sec. 371 Date Apr. 10, 1990 Sec. 102(e) Date Apr. 10, 1990 PCT Filed Aug. 10, 1989 PCT Pub. No. WO90/01500 PCT Pub. Date Feb. 22, 1990.The invention relates to iodine-containing polymers including a skeleton comprised of a dextrane to which are grafted groups having the formula (I), wherein the groups R are simultaneously groups derived from triiodobenzenic amines and groups derived from aliphatic amines.
Inventors
- 👤 Dominique Paris
- 👤 Michel Schaefer
- 👤 Didier Doucet
- 👤 Dominique Meyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:28
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0442
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
149 words
An iodinated polymer consisting essentially of a dextran backbone onto which are grafted groups of the formulae: ##STR20## wherein X is --NH--, ##STR21## n is an integer from 0 to 4, m is an integer from 1 to 5, R 1 is --COOH, --COOH made into a salt by a pharmaceutically acceptable base, or ##STR22## is ##STR23## and R' is C 1-4 alkyl, C 1-4 hdyroxyalkyl or poly(C 1-4 hydroxyalkyl); in which R 3 and R 5 are each independently C 1-6 alkyl, C 1-6 hydroxyalkyl, poly(C 1-6 hydroxyalkyl), C 1-6 alkoxy C 1-6 alkyl or C 1-6 alkoxy C 1-6 hydroxyalkyl, R 4 and R 6 are each independently H, or one of the values given for R 3 and R 5 , and in which R 3 may also be ##STR24## and wherein less than 20%of said grafted groups a), b) and c) are said groups c).
Claim 2
Dependent Claim
149 words
An iodinated polymer consisting essentially of a dextran backbone onto which are grafted groups of the formulae: ##STR20## wherein X is --NH--, ##STR21## n is an integer from 0 to 4, m is an integer from 1 to 5, R 1 is --COOH, --COOH made into a salt by a pharmaceutically acceptable base, or ##STR22## is ##STR23## and R' is C 1-4 alkyl, C 1-4 hdyroxyalkyl or poly(C 1-4 hydroxyalkyl); in which R 3 and R 5 are each independently C 1-6 alkyl, C 1-6 hydroxyalkyl, poly(C 1-6 hydroxyalkyl), C 1-6 alkoxy C 1-6 alkyl or C 1-6 alkoxy C 1-6 hydroxyalkyl, R 4 and R 6 are each independently H, or one of the values given for R 3 and R 5 , and in which R 3 may also be ##STR24## and wherein less than 20%of said grafted groups a), b) and c) are said groups c).
Claim 3
Dependent Claim
14 words
The polymer according to claim 1, wherein X is --O-- and n is 1.
Claim 4
Dependent Claim
85 words
A method of making the polymer according to claim 1, comprising: reacting a dextran with a grafting reagent having a chemical structure that converts the hydroxy groups of the dextran into grafting groups of the formula ##STR25## reacting said grafting groups on said dextran with an amine of the formula ##STR26## reacting the thus-obtained iodinated polymer with an amine of the formula H.sub.2 N--R' (VI); wherein Z is an activation group capable of reacting with the primary amino group of the amines (V) and (VI).
Claim 5
Dependent Claim
18 words
A contrast agent for radiography, consisting essentially of an aqueous solution of the polymer according to claim 1.
References Cited (Backward Citations)
US2708174A
Cited
GB1400985A
Cited
US4069306A
Cited
US4406878A
Cited
EP0146455A2
Cited
US4822594A
Cited
FR2610935A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-30 | 1995-12-30 | 1996-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-30 | 1999-12-30 | 2000-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-30 | 2003-12-30 | 2004-06-30 | $7700.00 | Window Closed / Lapsed |