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US5124155A
Expired / Lapsed
US
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Fibronectin wound-healing dressings
Assignee: Bausch and Lomb Surgical Inc
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Filing: 1990-09-17
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Granted: 1992-06-23
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Expires: 2010-09-17
Abstract
Abstract Wound healing dressings are prepared by flocculating fibronectin, a biologically active fragment or an analog thereof to produce a water-swellable gel. The gels, in the form of sheets, strips, wedges, strands or I-shaped cross-sections, are especially useful in promoting the healing of corneal, scleral dermal, incisional wounds or lesions. They can be used to enhance the results obtained in keratorefractive surgeries and the healing scleral incision for intraocular surgery.
Inventors
- 👤 Cary Reich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:53
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0047; A61K; A61K47/00; A61K47/30; A61K47/42; A61K9/00; A61K9/70; A61L26/0061; A61L26/008; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/14; A61L31/145
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
26 words
A wound-healing dressing comprising a water-swellable, substantially water insoluble shaped gel of fibronectin, a biologically active fragment of fibronectin or a biologically active analog of fibronectin.
Claim 2
Dependent Claim
26 words
A wound-healing dressing comprising a water-swellable, substantially water insoluble shaped gel of fibronectin, a biologically active fragment of fibronectin or a biologically active analog of fibronectin.
Claim 3
Dependent Claim
10 words
A dressing according to claim 1 which further comprises collagen.
Claim 4
Dependent Claim
11 words
A dressing according to claim 1 which further comprises a medicament.
Claim 5
Dependent Claim
12 words
A dressing according to claim 3 wherein the medicament is an antibiotic.
Claim 6
Dependent Claim
35 words
A dressing according to claim 3 wherein the medicament is selected from the group consisting of antibiotics, antimicrobial agents, antiviral agents, antiinflammatory agents, anti-protease agents, hormones, vitamins, analgesics, chelating agents, mitogenic agents and mixtures thereof.
Claim 7
Dependent Claim
23 words
A dressing according to claim 1 in the form of a sheet, strip, wedge, strand or a solid having an I-shaped cross section.
Claim 8
Dependent Claim
69 words
A water-swellable and substantially water-insoluble wound healing dressing prepared by a method comprising reacting a solution containing fibronectin or a biologically active fragment of fibronectin or a biologically active analog of fibronectin with an agent which changes the pH or osmolarity of the solution and thereby forming a fibronectin flocculent, recovering the floocculent from the solution, forming the flocculent into a desired solid shape and drying the solid shape.
Claim 9
Dependent Claim
69 words
A water-swellable and substantially water-insoluble wound healing dressing prepared by a method comprising reacting a solution containing fibronectin or a biologically active fragment of fibronectin or a biologically active analog of fibronectin with an agent which changes the pH or osmolarity of the solution and thereby forming a fibronectin flocculent, recovering the floocculent from the solution, forming the flocculent into a desired solid shape and drying the solid shape.
Claim 10
Dependent Claim
21 words
A method for promoting the healing of a corneal wound comprising inserting into the wound a dressing according to claim 1.
Claim 11
Dependent Claim
21 words
A method for promoting the healing of a corneal wound comprising inserting into the wound a dressing according to claim 8.
Claim 12
Dependent Claim
9 words
The dressing according to claim 7 further comprising collagen.
References Cited (Backward Citations)
US4983181A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-23 | 1995-12-23 | 1996-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-23 | 1999-12-23 | 2000-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-23 | 2003-12-23 | 2004-06-23 | $7700.00 | Window Closed / Lapsed |