Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides

Claim 1

A method for the treatment of myocardial ischemia and arrhythmia comprising administering to a mammalian specie in need thereof a therapeutically effective amount of a compound having the formula ##STR17## and to acid addition salts and quaternary ammonium salts thereof, wherein R and R 1 each independently represent hydrogen, halo, lower alkyl, lower alkoxy, trihalomethyl, nitro, amino or hydroxy; X represents oxa (--O--) or thia (--S--); B represents a basic nitrogen-containing radical of the formula ##STR18## A and A' are independently selected from hydrogen or lower alkyl; m is zero or an integer from 1 to 3; n represents an integer from 2-5; p and p' are the same or different integer of 1 to 3; ##STR19## R 2 is lower alkyl, aryl, aralkyl, cycloalkyl(lower alkyl), lower alkenyl, lower alkadienyl, α-substituted phenyl alkyl, aralkenyl, aralkynyl or heteroaryl; and R 3 and R 4 are independently selected from hydrogen, lower alkyl, hydroxy lower alkyl, R substituted phenyl lower alkyl, R substituted cinnamoyl, 2- or 4-pyridylaklyl, and N-(lower alkyl)phenyl-(lower alkyl); or R 3 and R 4 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered monocyclic heterocycle which may contain one oxygen atom or one additional nitrogen atom and which heterocycle may be substituted by 1, 2 or 3 lower alkyl, lower alkoxy, hydroxy lower alkyl or lower alkanoyloxy-lower alkyl groups.

Claim 2

A method for the treatment of myocardial ischemia and arrhythmia comprising administering to a mammalian specie in need thereof a therapeutically effective amount of a compound having the formula ##STR17## and to acid addition salts and quaternary ammonium salts thereof, wherein R and R 1 each independently represent hydrogen, halo, lower alkyl, lower alkoxy, trihalomethyl, nitro, amino or hydroxy; X represents oxa (--O--) or thia (--S--); B represents a basic nitrogen-containing radical of the formula ##STR18## A and A' are independently selected from hydrogen or lower alkyl; m is zero or an integer from 1 to 3; n represents an integer from 2-5; p and p' are the same or different integer of 1 to 3; ##STR19## R 2 is lower alkyl, aryl, aralkyl, cycloalkyl(lower alkyl), lower alkenyl, lower alkadienyl, α-substituted phenyl alkyl, aralkenyl, aralkynyl or heteroaryl; and R 3 and R 4 are independently selected from hydrogen, lower alkyl, hydroxy lower alkyl, R substituted phenyl lower alkyl, R substituted cinnamoyl, 2- or 4-pyridylaklyl, and N-(lower alkyl)phenyl-(lower alkyl); or R 3 and R 4 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered monocyclic heterocycle which may contain one oxygen atom or one additional nitrogen atom and which heterocycle may be substituted by 1, 2 or 3 lower alkyl, lower alkoxy, hydroxy lower alkyl or lower alkanoyloxy-lower alkyl groups.